Oral Fluvoxamine With Inhaled Budesonide for Treatment of Early-Onset COVID-19 : A Randomized Platform Trial.

Autor: Reis G; ViRx@Stanford, Stanford Biosecurity and Pandemic Preparedness Initiative, Stanford, California; Research Division, Cardresearch - Cardiologia Assistencial e de Pesquisa, Belo Horizonte, Brazil; Department of Medicine, Pontifícia Universidade Católica de Minas Gerais, Minas Gerais, Brazil; and Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada (G.R.)., Dos Santos Moreira Silva EA; Research Division, Cardresearch - Cardiologia Assistencial e de Pesquisa, Belo Horizonte, Brazil, and Department of Medicine, Pontifícia Universidade Católica de Minas Gerais, Minas Gerais, Brazil (E.A.d.S.M.S., D.C.M.S., V.H.d.S.C., C.V.Q.d.S.)., Medeiros Silva DC; Research Division, Cardresearch - Cardiologia Assistencial e de Pesquisa, Belo Horizonte, Brazil, and Department of Medicine, Pontifícia Universidade Católica de Minas Gerais, Minas Gerais, Brazil (E.A.d.S.M.S., D.C.M.S., V.H.d.S.C., C.V.Q.d.S.)., Thabane L; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada (L.T., S.S., P.M., G.H.G.)., de Souza Campos VH; Research Division, Cardresearch - Cardiologia Assistencial e de Pesquisa, Belo Horizonte, Brazil, and Department of Medicine, Pontifícia Universidade Católica de Minas Gerais, Minas Gerais, Brazil (E.A.d.S.M.S., D.C.M.S., V.H.d.S.C., C.V.Q.d.S.)., Ferreira TS; Research Division, Cardresearch - Cardiologia Assistencial e de Pesquisa, Belo Horizonte, Brazil (T.S.F., M.I.C.S., L.B.R., R.O.)., Quirino Dos Santos CV; Research Division, Cardresearch - Cardiologia Assistencial e de Pesquisa, Belo Horizonte, Brazil, and Department of Medicine, Pontifícia Universidade Católica de Minas Gerais, Minas Gerais, Brazil (E.A.d.S.M.S., D.C.M.S., V.H.d.S.C., C.V.Q.d.S.)., Ribeiro Nogueira AM; Public Health Care Division, City of Ibirité, Brazil (A.M.R.N.)., Figueiredo Guimaraes Almeida AP; Department of Public Health at UNIFIPMoc and Family Medicine Fellowship Program, City of Montes Claros, Brazil (A.P.F.G.A.)., Cançado Monteiro Savassi L; Public Health, Mental and Family Medicine Department, Ouro Preto Federal University, Minas Gerais, Brazil (L.C.M.S.)., de Figueiredo Neto AD; Public Health Fellowship Program, Governador Valadares Public Health Authority, Minas Gerais, Brazil (A.D.d.F.N.)., Bitarães C; Public Health, Mental and Family Medicine Department, Ouro Preto Federal University, Minas Gerais, Brazil, and Public Health Care Division, City of Ibirité, Brazil (C.B., A.C.M.)., Cruz Milagres A; Public Health, Mental and Family Medicine Department, Ouro Preto Federal University, Minas Gerais, Brazil, and Public Health Care Division, City of Ibirité, Brazil (C.B., A.C.M.)., Diniz Callegari E; Department of Public Health at UNIFIPMoc and Family Medicine Fellowship Program, City of Montes Claros, Brazil, and Public Health Care Division, City of Brumadinho, Brazil (E.D.C.)., Campos Simplicio MI; Research Division, Cardresearch - Cardiologia Assistencial e de Pesquisa, Belo Horizonte, Brazil (T.S.F., M.I.C.S., L.B.R., R.O.)., Barra Ribeiro L; Research Division, Cardresearch - Cardiologia Assistencial e de Pesquisa, Belo Horizonte, Brazil (T.S.F., M.I.C.S., L.B.R., R.O.)., Oliveira R; Research Division, Cardresearch - Cardiologia Assistencial e de Pesquisa, Belo Horizonte, Brazil (T.S.F., M.I.C.S., L.B.R., R.O.)., Harari O; Cytel, Vancouver, British Columbia, Canada (O.H., H.R.)., Wilson LA; Platform Life Sciences, Vancouver, British Columbia, Canada (L.A.W., J.I.F., C.M.G., J.R.S.)., Forrest JI; Platform Life Sciences, Vancouver, British Columbia, Canada (L.A.W., J.I.F., C.M.G., J.R.S.)., Ruton H; Cytel, Vancouver, British Columbia, Canada (O.H., H.R.)., Sprague S; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada (L.T., S.S., P.M., G.H.G.)., McKay P; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada (L.T., S.S., P.M., G.H.G.)., Guo CM; Platform Life Sciences, Vancouver, British Columbia, Canada (L.A.W., J.I.F., C.M.G., J.R.S.)., Guyatt GH; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada (L.T., S.S., P.M., G.H.G.)., Rayner CR; Certara, Princeton, New Jersey, and Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia (C.R.R.)., Boulware DR; Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota (D.R.B.)., Ezer N; Department of Medicine, Division of Respiratory Medicine, McGill University Health Centre, Montréal, Québec, Canada (N.E.)., Lee TC; Division of Infectious Diseases, Department of Medicine, McGill University Health Centre, Montréal, Québec, Canada (T.C.L.)., McDonald EG; Division of General Internal Medicine, Department of Medicine, McGill University Health Centre, Montréal, Québec, Canada (E.G.M.)., Bafadhel M; School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom (M.B.)., Butler C; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom (C.B.)., Rodrigues Silva J; Platform Life Sciences, Vancouver, British Columbia, Canada (L.A.W., J.I.F., C.M.G., J.R.S.)., Dybul M; Global Health Institute, Georgetown University, Washington, DC (M.D.)., Mills EJ; ViRx@Stanford, Stanford Biosecurity and Pandemic Preparedness Initiative, Stanford, California; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada; Cytel, Vancouver, British Columbia, Canada; and Platform Life Sciences, Vancouver, British Columbia, Canada (E.J.M.).

Publikováno v: Annals of internal medicine [Ann Intern Med] 2023 May; Vol. 176 (5), pp. 667-675. Date of Electronic Publication: 2023 Apr 18.

Effect of early treatment with fluvoxamine on risk of emergency care and hospitalisation among patients with COVID-19: the TOGETHER randomised, platform clinical trial.

Autor: Reis G; Research Division, Cardresearch - Cardiologia Assistencial e de Pesquisa, Belo Horizonte, Brazil; Department of Medicine, Pontifícia Universidade Católica de Minas Gerais, Belo Horizonte, Brazil. Electronic address: Brazilgreis@cardresearch.org., Dos Santos Moreira-Silva EA; Research Division, Cardresearch - Cardiologia Assistencial e de Pesquisa, Belo Horizonte, Brazil; Department of Medicine, Pontifícia Universidade Católica de Minas Gerais, Belo Horizonte, Brazil., Silva DCM; Research Division, Cardresearch - Cardiologia Assistencial e de Pesquisa, Belo Horizonte, Brazil; Department of Medicine, Pontifícia Universidade Católica de Minas Gerais, Belo Horizonte, Brazil., Thabane L; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada., Milagres AC; Family Medicine, Mental and Public Health Department, Ouro Preto Federal University, Ouro Preto, Brazil; Public Health Care Division, City of Ibirité, Brazil., Ferreira TS; Research Division, Cardresearch - Cardiologia Assistencial e de Pesquisa, Belo Horizonte, Brazil., Dos Santos CVQ; Research Division, Cardresearch - Cardiologia Assistencial e de Pesquisa, Belo Horizonte, Brazil; Department of Medicine, Pontifícia Universidade Católica de Minas Gerais, Belo Horizonte, Brazil., de Souza Campos VH; Research Division, Cardresearch - Cardiologia Assistencial e de Pesquisa, Belo Horizonte, Brazil; Department of Medicine, Pontifícia Universidade Católica de Minas Gerais, Belo Horizonte, Brazil., Nogueira AMR; Department of Public Health at UniFipMoc and Family Medicine Fellowship Program, Montes Claros, Brazil., de Almeida APFG; Department of Public Health at UniFipMoc and Family Medicine Fellowship Program, Montes Claros, Brazil., Callegari ED; Public Health Care Division, City of Brumadinho, Brazil., de Figueiredo Neto AD; Juiz de Fora Federal University, Juiz de Fora, Brazil; Public Health Fellowship Program, Governador Valadares Public Health Authority, Governador Valadares, Brazil., Savassi LCM; Family Medicine, Mental and Public Health Department, Ouro Preto Federal University, Ouro Preto, Brazil., Simplicio MIC; Research Division, Cardresearch - Cardiologia Assistencial e de Pesquisa, Belo Horizonte, Brazil., Ribeiro LB; Research Division, Cardresearch - Cardiologia Assistencial e de Pesquisa, Belo Horizonte, Brazil., Oliveira R; Research Division, Cardresearch - Cardiologia Assistencial e de Pesquisa, Belo Horizonte, Brazil., Harari O; Cytel, Vancouver, BC, Canada., Forrest JI; Cytel, Vancouver, BC, Canada., Ruton H; Cytel, Vancouver, BC, Canada., Sprague S; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada., McKay P; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada., Glushchenko AV; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada., Rayner CR; Certara, Princeton, NJ, USA; Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia., Lenze EJ; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA., Reiersen AM; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA., Guyatt GH; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada., Mills EJ; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada. Electronic address: millsej@mcmaster.ca.

Publikováno v: The Lancet. Global health [Lancet Glob Health] 2022 Jan; Vol. 10 (1), pp. e42-e51. Date of Electronic Publication: 2021 Oct 28.