Molecular Hybridization Strategy on the Design, Synthesis, and Structural Characterization of Ferrocene- N -acyl Hydrazones as Immunomodulatory Agents.

Autor: Silva LP; Department of Life Sciences, State University of Bahia (UNEB), Salvador 41150-000, BA, Brazil., Santos IP; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador 40296-710, BA, Brazil., Silva DKC; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador 40296-710, BA, Brazil., Dos Reis BPZC; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador 40296-710, BA, Brazil., Meira CS; Department of Life Sciences, State University of Bahia (UNEB), Salvador 41150-000, BA, Brazil.; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador 40296-710, BA, Brazil.; Institute for Innovation in Advanced Health Systems (CIMATEC ISI SAS-University Center SENAI/CIMATEC), Salvador 41650-010, BA, Brazil., Castro MVBS; Laboratory of Design and Synthesis Applied to Medicinal Chemistry-SintMed®, Center for Technology and Geosciences, Federal University of Pernambuco, Recife 50740-521, PE, Brazil., Dos Santos Filho JM; Laboratory of Design and Synthesis Applied to Medicinal Chemistry-SintMed®, Center for Technology and Geosciences, Federal University of Pernambuco, Recife 50740-521, PE, Brazil., Araujo-Neto JH; Multiuser Laboratory of Structural Crystallography, Institute of São Carlos, University of São Paulo, São Carlos 13566-590, SP, Brazil., Ellena JA; Multiuser Laboratory of Structural Crystallography, Institute of São Carlos, University of São Paulo, São Carlos 13566-590, SP, Brazil., Silveira RGD; Multiuser Laboratory of Structural Crystallography, Institute of São Carlos, University of São Paulo, São Carlos 13566-590, SP, Brazil.; Department of Chemistry, Federal Institute of Goiás, Campus Ceres, Ceres 76300-000, GO, Brazil., Soares MBP; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador 40296-710, BA, Brazil.; Institute for Innovation in Advanced Health Systems (CIMATEC ISI SAS-University Center SENAI/CIMATEC), Salvador 41650-010, BA, Brazil.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2022 Nov 30; Vol. 27 (23). Date of Electronic Publication: 2022 Nov 30.

Structural design, synthesis and substituent effect of hydrazone-N-acylhydrazones reveal potent immunomodulatory agents.

Autor: Meira CS; FIOCRUZ, Instituto Gonçalo Moniz, 40296-710 Salvador, BA, Brazil., Dos Santos Filho JM; UFPE, Centro de Tecnologia e Geociências, Laboratory of Design and Synthesis Applied to Medicinal Chemistry-SintMed(®), CEP 50740-521 Recife, PE, Brazil., Sousa CC; FIOCRUZ, Instituto Gonçalo Moniz, 40296-710 Salvador, BA, Brazil., Anjos PS; FIOCRUZ, Instituto Gonçalo Moniz, 40296-710 Salvador, BA, Brazil., Cerqueira JV; FIOCRUZ, Instituto Gonçalo Moniz, 40296-710 Salvador, BA, Brazil., Dias Neto HA; UFPE, Centro de Tecnologia e Geociências, Laboratory of Design and Synthesis Applied to Medicinal Chemistry-SintMed(®), CEP 50740-521 Recife, PE, Brazil., da Silveira RG; IFG, Campus Ceres, CEP 76300-000 Ceres, GO, Brazil., Russo HM; School of Pharmaceutical Sciences, EPGL, University of Geneva, University of Lausanne, CMU - Rue Michel-Servet 1, CH-1211 Geneva 4, Switzerland., Wolfender JL; School of Pharmaceutical Sciences, EPGL, University of Geneva, University of Lausanne, CMU - Rue Michel-Servet 1, CH-1211 Geneva 4, Switzerland., Queiroz EF; School of Pharmaceutical Sciences, EPGL, University of Geneva, University of Lausanne, CMU - Rue Michel-Servet 1, CH-1211 Geneva 4, Switzerland., Moreira DRM; FIOCRUZ, Instituto Gonçalo Moniz, 40296-710 Salvador, BA, Brazil., Soares MBP; FIOCRUZ, Instituto Gonçalo Moniz, 40296-710 Salvador, BA, Brazil; Centro de Biotecnologia e Terapia Celular, Hospital São Rafael, 41253-190 Salvador, BA, Brazil. Electronic address: milena@bahia.fiocruz.br.

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2018 May 01; Vol. 26 (8), pp. 1971-1985. Date of Electronic Publication: 2018 Feb 25.

Optimization of anti-Trypanosoma cruzi oxadiazoles leads to identification of compounds with efficacy in infected mice.

Autor: dos Santos Filho JM; Departamento de Engenharia Química, Centro de Tecnologia e Geociências, Universidade Federal de Pernambuco, CEP 50740-521, Recife, PE, Brazil. mauricio_santosfilho@yahoo.com.br, Moreira DR, de Simone CA, Ferreira RS, McKerrow JH, Meira CS, Guimarães ET, Soares MB

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2012 Nov 01; Vol. 20 (21), pp. 6423-33. Date of Electronic Publication: 2012 Aug 31.