MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice

Autor: Ying, Wei, Gao, Hong, Dos Reis, Felipe Castellani Gomes, Bandyopadhyay, Gautam, Ofrecio, Jachelle M., Luo, Zhenlong, Ji, Yudong, Jin, Zhongmou, Ly, Crystal, Olefsky, Jerrold M.

Publikováno v: In Cell Metabolism 6 April 2021 33(4):781-790

Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075

Autor: Ji, Yudong, Luo, Zhenlong, Gao, Hong, Dos Reis, Felipe Castellani Gomes, Bandyopadhyay, Gautam, Jin, Zhongmou, Manda, Kameswari Ananthakrishnan, Isaac, Roi, Yang, Meixiang, Fu, Wenxian, Ying, Wei, Olefsky, Jerrold M

Publikováno v: Nature metabolism, vol 3, iss 9

In chronic obesity, hepatocytes become insulin resistant and exert important effects on systemic metabolism. Here we show that in early onset obesity (4 weeks high-fat diet), hepatocytes secrete exosomes that enhance insulin sensitivity both in vitro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::9eb36b92b9109a785efa010797667b14
https://escholarship.org/uc/item/9mr1241r

Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075.

Autor: Ji Y; Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, CA, USA.; Department of Anesthesiology, Institute of Anesthesiology and Critical Care, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Luo Z; Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, CA, USA.; Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Gao H; Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, CA, USA., Dos Reis FCG; Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, CA, USA., Bandyopadhyay G; Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, CA, USA., Jin Z; Division of Biological Sciences, University of California, San Diego, CA, USA., Manda KA; Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, CA, USA., Isaac R; Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, CA, USA., Yang M; Pediatric Diabetes Research Center, Department of Pediatrics, University of California, San Diego, CA, USA.; Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, the Biomedical Translational Research Institute, Jinan University, Guangzhou, China., Fu W; Pediatric Diabetes Research Center, Department of Pediatrics, University of California, San Diego, CA, USA.; Department of Cancer Immunology, Genentech, San Francisco, CA, USA., Ying W; Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, CA, USA. weying@health.ucsd.edu., Olefsky JM; Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, CA, USA. jolefsky@health.ucsd.edu.

Publikováno v: Nature metabolism [Nat Metab] 2021 Sep; Vol. 3 (9), pp. 1163-1174. Date of Electronic Publication: 2021 Sep 06.