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Publikováno v:
Human Pathology. 136:56-62
Publikováno v:
HistopathologyReferences. 81(2)
It remains controversial as to whether targeted biopsies should completely replace random biopsies for dysplasia surveillance in patients with inflammatory bowel disease (IBD). Several histologic patterns of nonconventional dysplasia have been descri
Autor:
Constantine N. Tzouanas, Maria M. Mihaylova, Peter Carmeliet, Shinya Imada, Dorukhan Bahceci, Anna T. Webb, Amanda M. Hussey, Ömer H. Yilmaz, Yesenia Barrera Millan, Alex K. Shalek, Miyeko D. Mana, Caroline A. Lewis, Dominic R. Saiz
Publikováno v:
Cell reports
Elsevier
Mana, M D, Hussey, A M, Tzouanas, C N, Imada, S, Barrera Millan, Y, Bahceci, D, Saiz, D R, Webb, A T, Lewis, C A, Carmeliet, P, Mihaylova, M M, Shalek, A K & Yilmaz, Ö H 2021, ' High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity ', Cell Reports, vol. 35, no. 10, 109212 . https://doi.org/10.1016/j.celrep.2021.109212
CELL REPORTS
Elsevier
Mana, M D, Hussey, A M, Tzouanas, C N, Imada, S, Barrera Millan, Y, Bahceci, D, Saiz, D R, Webb, A T, Lewis, C A, Carmeliet, P, Mihaylova, M M, Shalek, A K & Yilmaz, Ö H 2021, ' High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity ', Cell Reports, vol. 35, no. 10, 109212 . https://doi.org/10.1016/j.celrep.2021.109212
CELL REPORTS
SUMMARY Obesity is an established risk factor for cancer in many tissues. In the mammalian intestine, a pro-obesity high-fat diet (HFD) promotes regeneration and tumorigenesis by enhancing intestinal stem cell (ISC) numbers, proliferation, and functi