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pro vyhledávání: '"Dorthy Levorse"'
Autor:
Martin Dolmaski, Brandon M. Taoka, Jared N. Cumming, Maria S. Michener, Lynn A. Hyde, Jinsong Hao, Brad E. Smith, Hongwu Wang, Wen-Lian Wu, Matthew E. Kennedy, Dorthy Levorse, Peter Orth, Eric M. Parker
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 56:128463
This paper describes the structure-activity-relationships of novel fluoroalkyl substituents at the C2 position of iminothiazine dioxide beta secretase inhibitors. Key discoveries include reduced amidine basicity and its effect on Pgp, cell potency, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::984b2c3cec4c248c956651aadfe2ea29
https://doi.org/10.1016/j.bmcl.2021.128463
https://doi.org/10.1016/j.bmcl.2021.128463
