Výsledky vyhledávání - "Dorthe Hellemann"

Effect of low vs high haemoglobin transfusion trigger on cardiac output in patients undergoing elective vascular surgery: Post‐hoc analysis of a randomized trial

Autor: Klaus V. Marcussen, Anders Pape Møller, Jørn Wetterslev, Benedicte G. U. Ramsing, Anette Mortensen, Niels H. Secher, Ole Birger Pedersen, Henning B. Nielsen, Dorthe Hellemann, Saeid Shahidi

Publikováno v: Acta Anaesthesiologica Scandinavica. 65:302-312

BACKGROUND During vascular surgery, restricted red-cell transfusion reduces frontal lobe oxygen (ScO2 ) saturation as determined by near-infrared spectroscopy. We evaluated whether inadequate increase in cardiac output (CO) following haemodilution ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c98ab6dc8ebb5c53ae85b72dc3859aac
https://doi.org/10.1111/aas.13733

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Autor: Peter Garred, Katrine Pilely, Markus K. Kristensen, Dorthe Hellemann, Rafael Bayarri-Olmos, Cecilie Bo Hansen

Publikováno v: The Journal of Infection

To evaluate the complement related pattern recognition molecules (PRMs) PTX3, MBL, CL-11, ficolin-2 and -3, along with the established marker CRP, to predict 28-day mortality and disease severity of sepsis in patients admitted to the intensive care u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89a1ab6ce632f2239c9d83047faacc05
https://doi.org/10.1016/j.jinf.2020.01.010

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Low vs high hemoglobin trigger for transfusion in vascular surgery: a randomized clinical feasibility trial

Autor: Klaus V. Marcussen, Anette Mortensen, Per Winkel, Benedicte G. U. Ramsing, Dorthe Hellemann, Jørn Wetterslev, Ole Birger Pedersen, Henning B. Nielsen, Saeid Shahidi, Anders Møller, Janus Christian Jakobsen

Publikováno v: Møller, A, Nielsen, H B, Wetterslev, J, Pedersen, O B, Hellemann, D, Winkel, P, Marcussen, K V, Ramsing, B G U, Mortensen, A, Jakobsen, J C & Shahidi, S 2019, ' Low vs high hemoglobin trigger for transfusion in vascular surgery : a randomized clinical feasibility trial ', Blood, vol. 133, no. 25, pp. 2639-2650 . https://doi.org/10.1182/blood-2018-10-877530

Current guidelines advocate to limit red blood cell (RBC) transfusion during surgery, but the feasibility and safety of such a strategy remain unclear, as the majority of evidence is based on postoperatively stable patients. We assessed the effects o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::993de9b54a76871089e8c2b829ac11f5
https://pubmed.ncbi.nlm.nih.gov/31221788

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Plasma YKL-40 and CHI3L1 in systemic inflammation and sepsis—Experience from two prospective cohorts

Autor: Brian Kornblit, Jens J. Strøm, Julia S. Johansen, Lea Munthe-Fog, Dorthe Hellemann, Peter Garred, Hans O. Madsen, Jan Bonde

Publikováno v: Immunobiology. 218:1227-1234

YKL-40, derived from the CHI3L1 gene, has been associated with outcome of infectious and inflammatory diseases. We hypothesized that plasma YKL-40 concentrations and CHI3L1 genotype could be used as prognostic biomarkers in the assessment of systemic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::177b1b8775ade421c1c413e862dabc88
https://doi.org/10.1016/j.imbio.2013.04.010

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The Lectin Complement Pathway in Patients with Necrotizing Soft Tissue Infection

Autor: Estrid Hein, Lars S. Rasmussen, Dorthe Hellemann, Ole Hyldegaard, Katrine Pilely, Peter Garred, Martin Bruun Madsen, Marco Bo Hansen

Publikováno v: Journal of innate immunity. 8(5)

Background: Mannose-binding lectin (MBL) and ficolins are pattern recognition molecules (PRMs) that play an important role during infection through activation of the lectin complement pathway. We assessed whether plasma PRM levels were associated wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3522569436a0306d85767993d32fa8fe
https://pubmed.ncbi.nlm.nih.gov/27355483

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The lectin complement pathway and Ficolin-2 in patients with necrotizing soft tissue infection

Autor: Marco Bo Hansen, Lars Simon Rasmussen, Katrine Pilely, Dorthe Hellemann, Estrid Hein, Martin Bruun Madsen, Ole Hyldegaard, Peter Garred

Publikováno v: The Journal of Immunology. 196:124.39-124.39

Background Mannose-binding lectin (MBL) and ficolins are pattern recognition molecules (PRMs) that play an important role during infection through activation of the lectin complement pathway. We assessed whether blood concentrations of the PRMs were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06c9f1e5c8d71a1d6afa8b7eead9df60
https://doi.org/10.4049/jimmunol.196.supp.124.39

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Heterozygosity of mannose-binding lectin (MBL2) genotypes predicts advantage (heterosis) in relation to fatal outcome in intensive care patients

Autor: Hans O. Madsen, Jørn Wetterslev, Jørgen Wiis, Dorthe Hellemann, Torsten Faber, Jens Otto Jarløv, Anders Larsson, Jan Bonde, Peter Garred

Publikováno v: Hellemann, D, Larsson, A, O. Madsen, H, Bonde, J, Jarløv, J O, Wiis, J, Faber, T, Wetterslev, J & Garred, P 2007, ' Heterozygosity of mannose-binding lectin (MBL2) genotypes predicts advantage (heterosis) in relation to fatal outcome in intensive care patients ', Human Molecular Genetics, pp. 3071-3080 .

Polymorphisms in the MBL2 gene, which affect the structure and influence on the serum concentration of mannose-binding lectin (MBL), are associated with inflammatory and infectious conditions. The importance of MBL2 polymorphisms on outcome in critic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f37f3e99345c2e989a219e3d30f963
https://pure.au.dk/portal/da/publications/heterozygosity-of-mannosebinding-lectin-mbl2-genotypes-predicts-advantage-heterosis-in-relation-to-fatal-outcome-in-intensive-care-patients(d67ab7f0-bf5e-11dc-88d5-000ea68e967b).html

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