Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Dorthe Helena Larsen"'
Autor:
George Pappas, Sebastian Howen Nesgaard Munk, Kenji Watanabe, Quentin Thomas, Zita Gál, Helena Hagner Gram, MyungHee Lee, Daniel Gómez-Cabello, Dimitris Christos Kanellis, Pedro Olivares-Chauvet, Dorthe Helena Larsen, Lea Haarup Gregersen, Apolinar Maya-Mendoza, Panagiotis Galanos, Jiri Bartek
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111979- (2023)
Summary: The role of MDC1 in the DNA damage response has been extensively studied; however, its impact on other cellular processes is not well understood. Here, we describe the role of MDC1 in transcription as a regulator of RNA polymerase II (RNAPII
Externí odkaz:
https://doaj.org/article/50019a16f1e04bee8a3f5e43aa9acc20
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Treacle/TCOF1 is an adaptor protein specifically associated with nucleolar chromatin. In the nucleolus it stimulates ribosome biogenesis, thereby promoting growth and proliferation. A second role of Treacle has emerged as a coordinator of the nucleol
Externí odkaz:
https://doaj.org/article/1fb9bc3a390c47ebb61695b61b74ff60
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The importance of chromatin environment for DNA repair has gained increasing recognition in recent years. The nucleolus is the largest sub-compartment within the nucleus: it has distinct biophysical properties, selective protein retention, and houses
Externí odkaz:
https://doaj.org/article/0787ce1122c74a3abbf47bfdf200ee2c
Autor:
Marco Demaria, Jiri Bartek, Athanassios Kotsinas, Andriani Angelopoulou, Eduardo G. Gusmao, Konstantinos Sofiadis, Ioanna Mourkioti, Yajie Zhu, Aristotelis Tsirigos, Vassilis G. Gorgoulis, Nicola Crosetto, Alexandros Polyzos, Panagiotis Galanos, Argyris Papantonis, Dafni-Eleftheria Pefani, Timokratis Karamitros, Apolinar Maya-Mendoza, Aikaterini Polyzou, Reza Mirzazadeh, Zita Gál, Konstantinos Evangelou, Athanasia Mizi, Nefeli Lagopati, Silvano Garnerone, Dorthe Helena Larsen, Christos P. Zampetidis, Angelos Papaspyropoulos
Publikováno v:
Molecular Cell, 81(23), 4907-4923. CELL PRESS
Oncogene-induced senescence (OIS) is an inherent and important tumor suppressor mechanism. However, if not removed timely via immune surveillance, senescent cells also have detrimental effects. Although this has mostly been attributed to the senescen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b80d31f8544b57867ebc89f2b5a6c9a
https://research.rug.nl/en/publications/47cc98db-767e-48fe-b330-e8de9e2ccbc3
https://research.rug.nl/en/publications/47cc98db-767e-48fe-b330-e8de9e2ccbc3
Autor:
Jiri Bartek, Lea Milling Korsholm, Yonglun Luo, Oliver Quevedo, Diana A Ahmad, Lin Lin, Ekaterina Dulina, Zita Gál, Dorthe Helena Larsen
Publikováno v:
Nucleic Acids Research
Korsholm, L M, Gál, Z, Lin, L, Quevedo, O, Ahmad, D A, Dulina, E, Luo, Y, Bartek, J & Larsen, D H 2019, ' Double-strand breaks in ribosomal RNA genes activate a distinct signaling and chromatin response to facilitate nucleolar restructuring and repair ', Nucleic Acids Research, vol. 47, no. 15, pp. 8019-8035 . https://doi.org/10.1093/nar/gkz518
Korsholm, L M, Gál, Z, Lin, L, Quevedo, O, Ahmad, D A, Dulina, E, Luo, Y, Bartek, J & Larsen, D H 2019, ' Double-strand breaks in ribosomal RNA genes activate a distinct signaling and chromatin response to facilitate nucleolar restructuring and repair ', Nucleic Acids Research, vol. 47, no. 15, pp. 8019-8035 . https://doi.org/10.1093/nar/gkz518
The nucleolus is a nuclear sub-domain containing the most highly transcribed genes in the genome. Hundreds of human ribosomal RNA (rRNA) genes, located in the nucleolus, rely on constant maintenance. DNA double-strand breaks (DSBs) in rRNA genes acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c413ca7d5858697481b46c3329c8e1
http://europepmc.org/articles/PMC6735822
http://europepmc.org/articles/PMC6735822
Autor:
Torben Bo Toldam-Andersen, Bjarne Joernsgaard, Renate Müller, Dorthe Helena Larsen, Bjoern Madsen, Mabel V. Martinez Vega, Tsaneta Dzhanfezova, Josefine Nymark Hegelund, Gregorio Barba-Espín
Publikováno v:
Food Bioscience, 36
Food Bioscience 36 (2020)
Food Bioscience 36 (2020)
Screening of strawberry anthocyanin composition and antioxidant capacities are important in the characterization and development of sources of natural colors. Here, Fragaria vesca (wild strawberry) and three commercial (cultivars ‘Elsanta’, ‘Ko
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c310ae6724c5816375176dd4a2bfdb85
https://research.wur.nl/en/publications/anthocyanin-profile-antioxidant-activity-and-total-phenolic-conte
https://research.wur.nl/en/publications/anthocyanin-profile-antioxidant-activity-and-total-phenolic-conte
Autor:
Jirina Bartkova, Martin Kosar, Mark R. Payne, Mikael S. Lindström, Dorthe Helena Larsen, Jiri Lukas, Jakob Bunkenborg, Jens S. Andersen, Martin V. Bennetzen, Jiri Bartek
Publikováno v:
Bennetzen, M V, Kosar, M, Bunkenborg, J, Payne, M R, Bartkova, J, Lindström, M S, Lukas, J, Andersen, J S, Bartek, J & Larsen, D H 2018, ' DNA damage-induced dynamic changes in abundance and cytosol-nuclear translocation of proteins involved in translational processes, metabolism, and autophagy ', Cell Cycle, vol. 17, no. 17, pp. 2146-2163 . https://doi.org/10.1080/15384101.2018.1515552
Ionizing radiation (IR) causes DNA double-strand breaks (DSBs) and activates a versatile cellular response regulating DNA repair, cell-cycle progression, transcription, DNA replication and other processes. In recent years proteomics has emerged as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3252bb36a9957bf5b0737f39a0e22944
https://europepmc.org/articles/PMC6226234/
https://europepmc.org/articles/PMC6226234/
Autor:
Martin V. Bennetzen, Christoffel Dinant, Jiri Bartek, Sugiko Watanabe, Jens S. Andersen, Dorthe Helena Larsen, Jiri Lukas
Publikováno v:
Bennetzen, M V, Larsen, D H, Dinant, C, Watanabe, S, Bartek, J, Lukas, J & Andersen, J S 2013, ' Acetylation dynamics of human nuclear proteins during the ionizing radiation-induced DNA damage response ', Cell Cycle, vol. 12, no. 11, pp. 1688-1695 . https://doi.org/10.4161/cc.24758
Genotoxic insults, such as ionizing radiation (IR), cause DNA damage that evokes a multifaceted cellular DNA damage response (DDR). DNA damage signaling events that control protein activity, subcellular localization, DNA binding, protein-protein inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462f2f4adb67092ccd2a0dc7cebe71d8
https://doi.org/10.4161/cc.24758
https://doi.org/10.4161/cc.24758
Autor:
Wouter W. Wiegant, Kum Kum Khanna, Simon Bekker-Jensen, Leena Ackermann, Haico van Attikum, Martijn S. Luijsterburg, Nico P. Dantuma, Niels Mailand, Klára Ács, Dorthe Helena Larsen
Publikováno v:
The EMBO Journal. 31:2511-2527
The ubiquitin ligases RNF8 and RNF168 orchestrate DNA damage signalling through the ubiquitylation of histone H2A and the recruitment of downstream repair factors. Here, we demonstrate that RNF8, but not RNF168 or the canonical H2A ubiquitin ligase R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5908c3c108805affe5b999b63d4cbdbf
https://doi.org/10.1038/emboj.2012.104
https://doi.org/10.1038/emboj.2012.104
Autor:
Christoffel Dinant, Catherine Poinsignon, Jannie Rendtlew Danielsen, Jette Christensen Sand, Patrice Menard, Jiri Bartek, Manuel Stucki, Flurina J. Hari, Claudia Lukas, Dorthe Helena Larsen, Mark R. Payne, Thorkell Gudjonsson, Jiri Lukas, Jens S. Andersen
Publikováno v:
The Journal of Cell Biology
The Journal of cell biology
Larsen, D H, Poinsignon, C, Gudjonsson, T, Dinant, C, Payne, M, Hari, F J, Danielsen, J M R, Menard, P, Sand, J C, Stucki, M, Lukas, C, Bartek, J, Andersen, J S & Lukas, J 2010, ' The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage ', Journal of Cell Biology, vol. 190, no. 5, pp. 731-740 . https://doi.org/10.1083/jcb.200912135
The Journal of Cell Biology; Vol 190
The Journal of cell biology
Larsen, D H, Poinsignon, C, Gudjonsson, T, Dinant, C, Payne, M, Hari, F J, Danielsen, J M R, Menard, P, Sand, J C, Stucki, M, Lukas, C, Bartek, J, Andersen, J S & Lukas, J 2010, ' The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage ', Journal of Cell Biology, vol. 190, no. 5, pp. 731-740 . https://doi.org/10.1083/jcb.200912135
The Journal of Cell Biology; Vol 190
The CHD4 helicase is identified as a new component of the genome surveillance machinery in a proteomic screen for factors enriched on chromatin after ionizing radiation (see also related paper by Smeenk et al. in this issue).
In response to ioni
In response to ioni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f53c813c15e06b5132b658444c33d1
https://doi.org/10.1083/jcb.200912135
https://doi.org/10.1083/jcb.200912135