Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Dorte Xenia Gram"'
Publikováno v:
Trends in molecular medicine. 23(11)
With an estimated 422 million affected patients worldwide in 2016, type 2 diabetes (T2D) has reached pandemic proportions and represents a major unmet medical need. T2D is a polygenic disease with a chronic, low-grade inflammatory component. Second-g
Autor:
Carsten F. Gotfredsen, Ana Charrua, Dorte Xenia Gram, Anker Jon Hansen, Josefine Fribo, István Nagy, John Bondo Hansen, Arpad Szallasi
Publikováno v:
Medical Sciences
Volume 7
Issue 8
Medical Sciences, Vol 7, Iss 8, p 82 (2019)
Volume 7
Issue 8
Medical Sciences, Vol 7, Iss 8, p 82 (2019)
With a global prevalence among adults over 18 years of age approaching 9%, Type 2 diabetes mellitus (T2DM) has reached pandemic proportions and represents a major unmet medical need. To date, no disease modifying treatment is available for T2DM patie
Autor:
Haiying Cheng, Xiaoning Fan, Rory J. McCrimmon, Yuyan Ding, Robert S. Sherwin, Dorte Xenia Gram
Publikováno v:
Diabetes
OBJECTIVE— In glucose-sensing neurons, ATP-sensitive K+ channels (KATP channels) are thought to translate metabolic signals into an alteration in neuronal firing rates. Because these neurons express the Kir6.2/SUR-1 isoform of the KATP channel, we
Autor:
Laust Peter Gade, Rasmus Rojkjaer, Dorte Xenia Gram, Mads Kjelgaard-Hansen, Bo Wiinberg, Annemarie T. Kristensen, Pär I. Johansson, Asger Lundorff Jensen
Publikováno v:
The Veterinary Journal. 174:62-68
Thromboelastography (TEG) may be a valuable supplement to the coagulation assays activated partial thromboplastin time (aPTT), prothrombin time (PT), thrombin time (TT), fibrinogen, antithrombin (AT) and D-Dimer currently used in most clinical pathol
Autor:
Richard D. Carr, Uffe Bang Olsen, Bo Ahrén, Péter Sántha, Christian L. Brand, Nils Wierup, Ove Svendsen, Dorte Xenia Gram, Frank Sundler, René Tabanera, Anker Jon Hansen, István Nagy
Publikováno v:
European Journal of Neuroscience. 25:213-223
The system that regulates insulin secretion from beta-cells in the islet of Langerhans has a capsaicin-sensitive inhibitory component. As calcitonin gene-related peptide (CGRP)-expressing primary sensory fibers innervate the islets, and a major propo
Autor:
Paw Bloch, Jacob Kofoed, Sanne Møller Knudsen, Jane Spetzler, Lotte Bjerre Knudsen, Ingrid Pettersson, Holger M. Strauss, Steffen Reedtz-Runge, Flemming S Nielsen, Thomas Kruse, Kjeld Madsen, Lauge Schäffer, Dorte Bjerre Steensgaard, Jesper Lau, Peter Thygesen, Dorte Xenia Gram, James N. McGuire
Publikováno v:
Journal of medicinal chemistry. 58(18)
Liraglutide is an acylated glucagon-like peptide-1 (GLP-1) analogue that binds to serum albumin in vivo and is approved for once-daily treatment of diabetes as well as obesity. The aim of the present studies was to design a once weekly GLP-1 analogue
Autor:
Dorte Xenia Gram, Anthony J. F. D'apice, Karsten Buschard, Axel Kornerup Hansen, Kirsten Dahl
Publikováno v:
APMIS. 114:805-811
Xenotransplantation holds the promise of replacing failing human organs with organs of animal origin. Transplantation of pancreatic islets from pigs to humans might restore glucose homeostasis and offer diabetic patients considerable improvement in t
Autor:
Richard D. Carr, Thora B. Bodvarsdottir, Bettina Ferrari, Wolfgang Langhans, Myrtha Arnold, Giovanni Pacini, Dorte Xenia Gram
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 289:R1027-R1034
We investigated the effect of subdiaphragmatic vagal deafferentation (SDA) on food intake, body weight gain, and metabolism in obese ( fa/ fa) and lean ( Fa/?) Zucker rats. Before and after recovery from surgery, food intake and body weight gain were
Autor:
Dorte Xenia Gram
Publikováno v:
Methods in Pharmacology and Toxicology ISBN: 9781627030946
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19c7d3357d05b83682212ac8f5ad11c5
https://doi.org/10.1007/978-1-62703-095-3_20
https://doi.org/10.1007/978-1-62703-095-3_20
Autor:
Owen Chan, Yuyan Ding, Xiaoning Fan, Ewan C. McNay, Robert S. Sherwin, Rory J. McCrimmon, Dorte Xenia Gram, Mark L. Evans, Wanling Zhu
Publikováno v:
Diabetes. 54(11)
The mechanism(s) by which glucosensing neurons detect fluctuations in glucose remains largely unknown. In the pancreatic beta-cell, ATP-sensitive K+ channels (K ATP channels) play a key role in glucosensing by providing a link between neuronal metabo