Retroviral glycoprotein-mediated immune suppression via the potassium channel KCa3.1 - A new strategy for amelioration of inflammatory bowel diseases

Autor: Magdalena J. Laska, Jesper Bonnet Moeller, Jonas Heilskov Graversen, Dorte Strøbæk, Linda Blomster, Palle Christophersen, Shervin Bahrami

Publikováno v: Laska, M J, Moeller, J B, Graversen, J H, Strøbæk, D, Blomster, L, Christophersen, P & Bahrami, S 2022, ' Retroviral glycoprotein-mediated immune suppression via the potassium channel KCa3.1-A new strategy for amelioration of inflammatory bowel diseases ', Clinical Immunology, vol. 242, pp. 109081 . https://doi.org/10.1016/j.clim.2022.109081

Peptides derived from retroviral envelope proteins have been shown to possess a wide range of immunosuppressive and anti-inflammatory activities. We have previously reported identification of such a peptide derived from the envelope protein coded by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfcaf4ee9a3fc150f17aaa8e0dc8ef6c
https://pure.au.dk/portal/da/publications/retroviral-glycoproteinmediated-immune-suppression-via-the-potassium-channel-kca31--a-new-strategy-for-amelioration-of-inflammatory-bowel-diseases(efe8f5f7-df1d-4814-9eb5-52a5146da0d1).html

Retroviral Glycoprotein-Mediated Immune Suppression via the potassium Channel KCa3.1- A new strategy for treatment of Inflammatory Bowel Diseases

Autor: Magdalena Laska, Jesper Bonnet Møller, Jonas Heilskov Graversen, Dorte Strøbæk, Linda Blomster, Palle Christophersen, Shervin Bahrami

Background and Purpose: Peptides derived from retroviral envelope proteins have been shown to possess a wide range of immunosuppressive and anti-inflammatory activities. We have previously reported identification of such a peptide derived from the en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::66b9c8ee9f0f64207ed6996eff417868
https://doi.org/10.22541/au.164181344.48884602/v1

Quantification of the functional expression of the Ca2+-activated K+channel KCa3.1 on microglia from adult human neocortical tissue

Autor: Linda V. Blomster, Jessica Klein, Palle Christophersen, Dorte Strøbæk, Jens D. Mikkelsen, Lars H. Pinborg, Charlotte Hougaard

Publikováno v: Glia. 64:2065-2078

The KCa 3.1 channel (KCNN4) is an important modulator of microglia responses in rodents, but no information exists on functional expression on microglia from human adults. We isolated and cultured microglia (max 1% astrocytes, no neurons or oligodend

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13e7878a041880d54d0c6aa905a51dd5
https://doi.org/10.1002/glia.23040

NS19504: A Novel BK Channel Activator with Relaxing Effect on Bladder Smooth Muscle Spontaneous Phasic Contractions

Autor: Dorte Strøbæk, Adrian D. Bonev, Frederik Rode, Susanne Jørgensen, Mark T. Nelson, William Dalby Brown, Tino Dyhring, Bernhard Nausch, Søren-Peter Olesen, Morten Grunnet, Antonio Nardi, Charlotte Hougaard, Palle Christophersen, Lars Christian Biilmann Rønn, Mads P.G. Korsgaard

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 350:520-530

Large-conductance Ca(2+)-activated K(+) channels (BK, KCa1.1, MaxiK) are important regulators of urinary bladder function and may be an attractive therapeutic target in bladder disorders. In this study, we established a high-throughput fluorometric i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ba2462188cf1db3c1450e981a2e8eb
https://doi.org/10.1124/jpet.113.212662

Biophysical and pharmacological characterization of α6-containing nicotinic acetylcholine receptors expressed in HEK293 cells

Autor: Daniel B. Timmermann, Philip K. Ahring, Morten Grunnet, Dorte Strøbæk, Tino Dyhring, Dan Peters, Andreas H. Rasmussen, Marianne L. Jensen

Publikováno v: Brain Research. 1542:1-11

Nicotinic acetylcholine receptors (nAChR's) containing the α6 subunit (α6) are putative drug targets of relevance to Parkinson's disease and nicotine addiction. However, heterologous expression of α6 receptors has proven challenging which has stif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8281c39e03cbdc267103637437c270e2
https://doi.org/10.1016/j.brainres.2013.10.024