Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Dorte M. Skytt"'
Autor:
Melis Karaca, Francesca Frigerio, Stephanie Migrenne, Juliette Martin-Levilain, Dorte M. Skytt, Kamilla Pajecka, Rafael Martin-del-Rio, Rolf Gruetter, Jorge Tamarit-Rodriguez, Helle S. Waagepetersen, Christophe Magnan, Pierre Maechler
Publikováno v:
Cell Reports, Vol 13, Iss 2, Pp 365-375 (2015)
Glucose, the main energy substrate used in the CNS, is continuously supplied by the periphery. Glutamate, the major excitatory neurotransmitter, is foreseen as a complementary energy contributor in the brain. In particular, astrocytes actively take u
Externí odkaz:
https://doaj.org/article/311bd863533346e7834a636a5ebccc74
Publikováno v:
Molecular Neurobiology. 55:5353-5361
The Müller cells represent the predominant macroglial cell in the retina. In recent decades, Müller cells have been acknowledged to be far more influential on neuronal homeostasis in the retina than previously assumed. With its unique localization,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de8178667846d4b5fae8a479bcce3bac
https://doi.org/10.1007/s12035-017-0760-7
https://doi.org/10.1007/s12035-017-0760-7
Autor:
Dorte M. Skytt, Evy Lefevere, Lieve Moons, Inge Van Hove, Alicia Svare, Helle S. Waagepetersen, Anne Katrine Toft-Kehler, Miriam Kolko
Publikováno v:
Mitochondrion. 36:43-51
Growing evidence suggests that mitochondrial dysfunction might play a key role in the pathogenesis of age-related neurodegenerative inner retinal diseases such as diabetic retinopathy and glaucoma. Therefore, the present review provides a perspective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d32f4cab26e3dd07e29d5537fda7e0f
https://doi.org/10.1016/j.mito.2017.02.002
https://doi.org/10.1016/j.mito.2017.02.002
Autor:
Claus Desler, Iswariyaraja Sridevi Gurubaran, Linda Hildegaard Bergersen, Miriam Kolko, Dorte M. Skytt, Rupali Vohra, Ulrik L. Henriksen, Lene Juel Rasmussen
Publikováno v:
Mitochondrion. 36:52-59
Using the human Müller cell line, MIO-M1, the aim was to study the impact of mitochondrial inhibition in Müller glia through antimycin A treatment. MIO-M1 cell survival, levels of released lactate, mitochondrial function, and glutamate uptake were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c37621d00145b4bb16b625f7f7369568
https://doi.org/10.1016/j.mito.2017.02.003
https://doi.org/10.1016/j.mito.2017.02.003
Autor:
Arne Schousboe, Dorte M. Skytt, Jakob D. Nissen, Wolfgang Enard, Jarosław Bryk, Ioannis Zaganas, Svante Pääbo, Kasper Lykke, Malin H. Stridh, Helle S. Waagepetersen, Lasse K. Bak
Publikováno v:
Glia. 65:474-488
A key enzyme in brain glutamate homeostasis is glutamate dehydrogenase (GDH) which links carbohydrate and amino acid metabolism mediating glutamate degradation to CO2 and expanding tricarboxylic acid (TCA) cycle capacity with intermediates, i.e. anap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6090f3b3574faebaec9fb92f9414ff05
https://doi.org/10.1002/glia.23105
https://doi.org/10.1002/glia.23105
Autor:
Giorgia Bulli, Linda H. Bergersen, Dorte M. Skytt, Helle S. Waagepetersen, Blanca I. Aldana, Rupali Vohra, Miriam Kolko
Publikováno v:
Vohra, R, Aldana, B I, Bulli, G, Skytt, D M, Waagepetersen, H, Bergersen, L H & Kolko, M 2019, ' Lactate-Mediated Protection of Retinal Ganglion Cells ', Journal of Molecular Biology, vol. 431, no. 9, pp. 1878-1888 . https://doi.org/10.1016/j.jmb.2019.03.005
Loss of retinal ganglion cells (RGCs) is a leading cause of blinding conditions. The purpose of this study was to evaluate the effect of extracellular l -lactate on RGC survival facilitated through lactate metabolism and ATP production. We identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c77fc3a576733bf7a093c0c3dc94eeb
https://pubmed.ncbi.nlm.nih.gov/30878479
https://pubmed.ncbi.nlm.nih.gov/30878479
Autor:
Kristine K. Freude, Helle S. Waagepetersen, Blanca I. Aldana, Dorte M. Skytt, Miriam Kolko, Linda H. Bergersen, Rupali Vohra
Publikováno v:
Molecular neurobiology. 55(12)
Muller cells are pivotal in sustaining retinal ganglion cells, and an intact energy metabolism is essential for upholding Muller cell functions. The present study aimed to investigate the impact of lactate on Muller cell survival and function. Primar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3e73bf68c2e2c4a8fd153587cb7c158
https://pubmed.ncbi.nlm.nih.gov/29644598
https://pubmed.ncbi.nlm.nih.gov/29644598
Publikováno v:
Glia. 63:2313-2326
Astrocytes take up glutamate in the synaptic area subsequent to glutamatergic transmission by the aid of high affinity glutamate transporters. Glutamate is converted to glutamine or metabolized to support intermediary metabolism and energy production
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7229035c915ca06c5c293a11c1ee5ee
https://doi.org/10.1002/glia.22895
https://doi.org/10.1002/glia.22895
Autor:
Malin H. Stridh, Jakob D. Nissen, Dorte M. Skytt, Kamilla Pajęcka, Arne Schousboe, Helle S. Waagepetersen
Publikováno v:
Journal of Neuroscience Research. 93:1093-1100
Cultured astrocytes treated with siRNA to knock down glutamate dehydrogenase (GDH) were used to investigate whether this enzyme is important for the utilization of glutamate as an energy substrate. By incubation of these cells in media containing dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44a60cd2a83dbbe47640a3070f31e232
https://doi.org/10.1002/jnr.23568
https://doi.org/10.1002/jnr.23568
Autor:
F. Frigerio, Wolfgang Enard, A. Shousboe, K. Pajęcka, K. L. Pedersen, A. Plaitakis, Ioannis Zaganas, Svante Pääbo, Malin H. Stridh, J. P. Bolanos, Helle S. Waagepetersen, A. Klawonn, Dorte M. Skytt, P. Maechler
Publikováno v:
Journal of Neuroscience Research. 91:1084-1095
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58aac20f997745d0cd34e56accc2e29e
https://doi.org/10.1002/jnr.23236
https://doi.org/10.1002/jnr.23236