Výsledky vyhledávání - "Dorrelyn M. Martin"

Supplementary Table 1 from Efficacy of FGFR Inhibitors and Combination Therapies for Acquired Resistance in FGFR2-Fusion Cholangiocarcinoma

Autor: Sameek Roychowdhury, Aharon G. Freud, John Hays, Kristen K. Ciombor, Dorrelyn M. Martin, Thuy Dao, Amy M. Smith, Eric Samorodnitsky, Jharna Miya, Michele R. Wing, Julie W. Reeser, Hui-Zi Chen, Kelly M. Bailey, Mikayla Dantuono, Hannah Barker, Max Wilberding, Alexandria Lenyo, Melanie A. Krook

Primer sequences used for PCR and Sanger sequencing.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b42608d465fb41549fd11c1548623d69
https://doi.org/10.1158/1535-7163.22519083

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Data from Efficacy of FGFR Inhibitors and Combination Therapies for Acquired Resistance in FGFR2-Fusion Cholangiocarcinoma

The fibroblast growth factor receptor (FGFR) signaling pathway is aberrantly activated in approximately 15% to 20% of patients with intrahepatic cholangiocarcinoma. Currently, several FGFR kinase inhibitors are being assessed in clinical trials for p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f5f6e892ef6a15aec83851e3e501d11
https://doi.org/10.1158/1535-7163.c.6542283.v1

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Supplementary Figure 1 from Efficacy of FGFR Inhibitors and Combination Therapies for Acquired Resistance in FGFR2-Fusion Cholangiocarcinoma

Sequence for FGFR2-KIAA1598 fusion.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee6583ef2a4168c8f00b172f486ec2b
https://doi.org/10.1158/1535-7163.22519089.v1

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Supplementary Figure 2 from Efficacy of FGFR Inhibitors and Combination Therapies for Acquired Resistance in FGFR2-Fusion Cholangiocarcinoma

Sensitivity of the FGFR2 secondary mutations to FGFR inhibitors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2323b989b2e47681149c462f7de2ee90
https://doi.org/10.1158/1535-7163.22519086.v1

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Supplementary Text 1 from Efficacy of FGFR Inhibitors and Combination Therapies for Acquired Resistance in FGFR2-Fusion Cholangiocarcinoma

Sequence for the FGFR2-KIAA1598 fusion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::767268d5ee83bf8019641a1c6d46fcd2
https://doi.org/10.1158/1535-7163.22519080.v1

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Tumor heterogeneity and acquired drug resistance in FGFR2-fusion-positive cholangiocarcinoma through rapid research autopsy

Autor: Cynthia Timmers, Melanie A. Krook, Hui-Zi Chen, Thuy Dao, Michele R. Wing, Aharon G. Freud, Julie W. Reeser, Eric Samorodnitsky, Sameek Roychowdhury, Anoosha Paruchuri, Amy M. Smith, Russell Bonneville, Patricia Allenby, Kaitlin R. Baker, Jharna Miya, Dorrelyn M. Martin, Lianbo Yu, Kristin Dittmar

Publikováno v: Cold Spring Harbor Molecular Case Studies

Cholangiocarcinoma is a highly aggressive and lethal malignancy, with limited treatment options available. Recently, FGFR inhibitors have been developed and utilized in FGFR-mutant cholangiocarcinoma; however, resistance often develops and the genomi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0116fdb2d89103384a70420332a0b65
http://europepmc.org/articles/PMC6672025

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Abstract 2909: Rapid autopsy of metastatic cholangiocarcinoma demonstrates diverse patterns of clonal heterogeneity

Autor: Dorrelyn M. Martin, Eric Samorodnitsky, Julie W. Reeser, Patricia Allenby, Cynthia Timmers, Amy M. Smith, Jharna Miya, Anoosha Paruchuri, Thuy Dao, Lianbo Yu, Kaitlin R. Baker, Sameek Roychowdhury, Melanie A. Krook, Russell Bonneville, Michele R. Wing, Hui-Zi Chen, Aharon G. Freud, Sharon Cole, Kristin Dittmar

Publikováno v: Cancer Research. 79:2909-2909

Background: Cholangiocarcinoma is an aggressive and deadly bile duct cancer. Due to its poor prognosis and limited treatments beyond first-line therapy, in-depth characterization of cholangiocarcinoma is needed to facilitate the development of novel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01b3178125e2c99dc9b520069d075672
https://doi.org/10.1158/1538-7445.am2019-2909

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Abstract 335: Efficacy of FGFR inhibitors and combination therapies for acquired resistance in FGFR2-fusion cholangiocarcinoma

Autor: Julie W. Reeser, Jharna Miya, Alexandria M. Lenyo, Eric Samorodnitsky, Dorrelyn M. Martin, Thuy Dao, Michele R. Wing, Hui-Zi Chen, Mikayla Dantuono, Maxwell J. Wilberding, John L. Hays, Amy M. Smith, Kristen K. Ciombor, Aharon G. Freud, Sameek Roychowdhury, Hannah Barker, Kristin Dittmar, Melanie A. Krook

Publikováno v: Cancer Research. 79:335-335

Background. The fibroblast growth factor receptor (FGFR) signaling pathway is aberrantly activated in approximately 20% of cases of cholangiocarcinoma through various genomic alterations including gene fusions, point mutations, and copy number amplif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1aa05c0425479e1d83df523c4a302514
https://doi.org/10.1158/1538-7445.am2019-335

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