Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Dorothy Yu Huang"'
Autor:
Dorothy Yu Huang, Li Xie, Birget Moe, David Kinniburgh, Indranil Dey, Zong-Chao Ling, Kathryn L. Berezowski
Publikováno v:
Toxicology in Vitro. 73:105124
The animal-based Draize test remains the gold standard for assessment of ocular irritation. However, subjective scoring methods, species differences, and animal welfare concerns have spurred development of alternative test methods. In this study, a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f6af3f5a5c20a08f21e7f60ec2591b
https://doi.org/10.1016/j.tiv.2021.105124
https://doi.org/10.1016/j.tiv.2021.105124
Publikováno v:
Free Radical Biology and Medicine. 159:S77
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f043540f88364c03f9c9df77fbf6f83
https://doi.org/10.1016/j.freeradbiomed.2020.10.201
https://doi.org/10.1016/j.freeradbiomed.2020.10.201
Autor:
Dorothy Yu Huang, Jiao Chen, Weiping Zhang, Stephan Gabos, Biao Huang, Swanand Khare, Bharathi Devi Devendran, Can Jin, Tianhong Pan, Zhankun Xi
Publikováno v:
Analytical Biochemistry. 477:98-104
Over the past decade, the real-time cell analyzer (RTCA) has provided a good tool to the cell-based in vitro assay. Unlike the traditional systems that label the target cells with luminescence, fluorescence, or light absorption, RTCA monitors cell pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a57605572f3865567b4dfd480cb7fd8a
https://doi.org/10.1016/j.ab.2015.01.026
https://doi.org/10.1016/j.ab.2015.01.026
High-throughput screening assay for the environmental water samples using cellular response profiles
Autor:
Dorothy Yu Huang, Tianhong Pan, Weiping Zhang, Stephan Gabos, Swanand Khare, Haoran Li, Biao Huang
Publikováno v:
Ecotoxicology and Environmental Safety. 114:134-142
Chemical and physical analyses are commonly used as screening methods for the environmental water. However, these methods can only look for the targeted substance but may miss unexpected toxicants. Furthermore, the synergistic effects of mixture cann
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d06dfbbd56e43f9803e65bfc725180c
https://doi.org/10.1016/j.ecoenv.2015.01.020
https://doi.org/10.1016/j.ecoenv.2015.01.020
Autor:
Cristina Anton, Jian Deng, Can Jin, Stephan Gabos, Dorothy Yu Huang, Yile Zhang, Yau Shu Wong, Weiping Zhang
Publikováno v:
Mathematical biosciences and engineering : MBE. 14(3)
The effect of various toxicants on growth/death and morphology of human cells is investigated using the xCELLigence Real-Time Cell Analysis High Troughput in vitro assay. The cell index is measured as a proxy for the number of cells, and for each tes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8747a4dac99026c57a61ba44cd8ef92c
https://pubmed.ncbi.nlm.nih.gov/28092954
https://pubmed.ncbi.nlm.nih.gov/28092954
Publikováno v:
IEEE/ACM Transactions on Computational Biology and Bioinformatics. :1-1
Real-time cellular analyzer (RTCA) has been generally applied to test the cytotoxicity of chemicals. However, several factors impact the experimental quality. A non-negligible factor is the abnormal time-dependent cellular response curves (TCRCs) of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ae55d2f3e6bff5b03b70aa50a3cddb
https://doi.org/10.1109/tcbb.2019.2903094
https://doi.org/10.1109/tcbb.2019.2903094
Publikováno v:
IFAC Proceedings Volumes. 46:309-314
Conventional tests in environmental monitoring have been performed by quantifying levels of toxicity of specific substances such as pesticides or drugs, and then comparing with known toxicity thresholds. These tests are conducted using analytical che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17b17fd3abab970151483ebc4a9f162c
https://doi.org/10.3182/20131216-3-in-2044.00007
https://doi.org/10.3182/20131216-3-in-2044.00007
Autor:
Yile, Zhang, Yau Shu, Wong, Jian, Deng, Cristina, Anton, Stephan, Gabos, Weiping, Zhang, Dorothy Yu, Huang, Can, Jin
Publikováno v:
BioData Mining
Background Real Time Cell Analysis (RTCA) technology is used to monitor cellular changes continuously over the entire exposure period. Combining with different testing concentrations, the profiles have potential in probing the mode of action (MOA) of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d8ccca774595ca420fd8ca495057149
https://pubmed.ncbi.nlm.nih.gov/27182283
https://pubmed.ncbi.nlm.nih.gov/27182283
Autor:
Can Jin, Weiping Zhang, Tianhong Pan, Biao Huang, Stephan Gabos, Dorothy Yu Huang, Tianqing Pu, Jiao Chen
Publikováno v:
Journal of Bioinformatics and Computational Biology. 14:1650004
In order to promote the acceptance of cell-based toxicity testings, the accuracy of cytotoxicity test must be determined when compared to in vivo results. Traditional methods of cytotoxicity analysis, such as LC[Formula: see text] (concentration wher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2089392b152e08f2bf34b53dd7a085ff
https://doi.org/10.1142/s0219720016500049
https://doi.org/10.1142/s0219720016500049
Publikováno v:
Analytica chimica acta. 764
Although many indices have been developed to quantify chemical toxicity, substantial shortcoming is inherent in most of them, such as observation time dependence, insufficient robustness, and no comparison with the negative control. To assess the ext
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b80b74dfc918962464729043e1c7248f
https://pubmed.ncbi.nlm.nih.gov/23374213
https://pubmed.ncbi.nlm.nih.gov/23374213