Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Dorothy Tuan"'
Publikováno v:
Epigenetics, Vol 12, Iss 3, Pp 226-237 (2017)
LTR retrotransposons are repetitive DNA elements comprising ∼10% of the human genome. They are silenced by hypermethylation of cytosines in CpG dinucleotides and are considered parasitic DNA serving no useful function for the host genome. However,
Externí odkaz:
https://doaj.org/article/7e034bc4ffc64ae28ea805f1f68cc5da
Autor:
Xingguo Zhu, Tianxiang Hu, Meng Hsuan Ho, Yongchao Wang, Miao Yu, Niren Patel, Wenhu Pi, Jeong-Hyeon Choi, Hongyan Xu, Vadivel Ganapathy, Ferdane Kutlar, Abdullah Kutlar, Dorothy Tuan
Publikováno v:
Haematologica, Vol 102, Iss 12 (2017)
Hydroxyurea (HU), the first of two drugs approved by the US Food and Drug Administration for treating patients with sickle cell disease (SCD), produces anti-sickling effect by re-activating fetal γ-globin gene to enhance production of fetal hemoglob
Externí odkaz:
https://doaj.org/article/53eaa618682545f998578fcfc3dd9fdc
Autor:
Yafei Cai, Wenhu Pi, Satish Sivaprakasam, Xiaobin Zhu, Mingsheng Zhang, Jijun Chen, Levi Makala, Chunwan Lu, Jianchu Wu, Yong Teng, Betty Pace, Dorothy Tuan, Nagendra Singh, Honglin Li
Publikováno v:
PLoS Genetics, Vol 11, Iss 11, p e1005643 (2015)
The Ufm1 conjugation system is an ubiquitin-like modification system that consists of Ufm1, Uba5 (E1), Ufc1 (E2), and less defined E3 ligase(s) and targets. The biological importance of this system is highlighted by its essential role in embryogenesi
Externí odkaz:
https://doaj.org/article/babd42b3576c420ab8657301a3dc6d57
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47175 (2012)
The human embryonic, fetal and adult β-like globin genes provide a paradigm for tissue- and developmental stage-specific gene regulation. The fetal γ-globin gene is expressed in fetal erythroid cells but is repressed in adult erythroid cells. The m
Externí odkaz:
https://doaj.org/article/0186f97fac8f41cd84124bf28adca9cc
Autor:
Vadivel Ganapathy, Hongyan Xu, Wenhu Pi, Yongchao Wang, Meng Hsuan Ho, Abdullah Kutlar, Ferdane Kutlar, Xingguo Zhu, Dorothy Tuan, Jeong Hyeon Choi, Tianxiang Hu, Niren Patel, Miao Yu
Publikováno v:
Haematologica
Hydroxyurea (HU), the first of two drugs approved by the US Food and Drug Administration for treating patients with sickle cell disease (SCD), produces anti-sickling effect by re-activating fetal γ-globin gene to enhance production of fetal hemoglob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08732553bd851bb20c89ec38bbb8a83e
https://doi.org/10.3324/haematol.2017.175646
https://doi.org/10.3324/haematol.2017.175646
Publikováno v:
Epigenetics. 12:226-237
LTR retrotransposons are repetitive DNA elements comprising ∼10% of the human genome. They are silenced by hypermethylation of cytosines in CpG dinucleotides and are considered parasitic DNA serving no useful function for the host genome. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b478aba124aac10503c4f065d4fe6989
https://doi.org/10.1080/15592294.2017.1289300
https://doi.org/10.1080/15592294.2017.1289300
Autor:
Huidong Shi, Hongseok Ha, Tianxiang Hu, Miao Yu, Jeong Hyeon Choi, Xingguo Zhu, Wenhu Pi, Dorothy Tuan
Publikováno v:
Nucleic Acids Research
LTR retrotransposons are repetitive DNA elements comprising ∼10% of the human genome. However, LTR sequences are disproportionately present in human long, non-coding RNAs (lncRNAs). Whether and how the LTR lncRNAs serve biological functions are lar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0147290027a438c1b291f64f54b108ce
https://pubmed.ncbi.nlm.nih.gov/28132025
https://pubmed.ncbi.nlm.nih.gov/28132025
Autor:
Dorothy Tuan
Publikováno v:
Blood. 132:2341-2341
In the human beta-globin gene locus, an LTR retrotransposon derived from ERV-9 human endogenous retrovirus is located near the locus control region (LCR) far upstream of the globin genes. In transgenic mice carrying the 100 kb human globin gene locus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b9e40368e51955ef8ae30e1420c5cba
https://doi.org/10.1182/blood-2018-99-117280
https://doi.org/10.1182/blood-2018-99-117280
Publikováno v:
Nucleic Acids Research
In the human epsilon-globin gene locus, the HS2 enhancer in the Locus Control Region regulates transcription of the embryonic epsilon-globin gene located over 10 kb away. The mechanism of long-range HS2 enhancer function was not fully established. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a60c6bf89f6ab982d2ed0f40dfe61d
https://doi.org/10.1093/nar/gkm595
https://doi.org/10.1093/nar/gkm595
Publikováno v:
Journal of Molecular Biology. 350:883-896
The HS2 enhancer in the beta-globin locus control region (LCR) regulates transcription of the globin genes 10-50 kb away. Earlier studies show that a transcription mechanism initiated by the HS2 enhancer through the intervening DNA in the direction o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a13cd3ca85b1fcb15a691b7e930ef2e
https://doi.org/10.1016/j.jmb.2005.05.039
https://doi.org/10.1016/j.jmb.2005.05.039