Výsledky vyhledávání - "Dorothy M. Middleton"

Characterization and immuno-detection of AIDA-I adhesin isolated from porcine Escherichia coli

Autor: Elemir Simko, Y. Fang, Musangu Ngeleka, Dorothy M. Middleton

Publikováno v: Veterinary Microbiology. 109:65-73

A relatively high percentage of porcine Escherichia coli isolates from cases associated with neonatal and post-weaning diarrhea are positive for the gene encoding adhesin involved in diffuse adhesion I (AIDA-I). This gene and its corresponding protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55d86f918471c46854f173a03fe17374
https://doi.org/10.1016/j.vetmic.2005.04.018

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An Outbreak of Sheep-Associated Malignant Catarrhal Fever in Bison (Bison Bison) after Exposure to Sheep at a Public Auction Sale

Autor: Keith West, Jerry Haigh, Murray R. Woodbury, Hong Li, Timothy B. Crawford, John Berezowski, Brendan P. O'Connor, Greg D. Appleyard, Dorothy M. Middleton

Publikováno v: Journal of Veterinary Diagnostic Investigation. 17:55-58

An outbreak of malignant catarrhal fever (MCF) among bison sold at an auction market was studied for an 18-month period. Forty-five of 163 bison submitted for sale from 8 different bison farms died on 7 other destination farms. The outbreak began on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a65e03706ddadee07709edbb87caa9a
https://doi.org/10.1177/104063870501700110

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Increased gene expression and inflammatory cell infiltration caused by electroporation are both important for improving the efficacy of DNA vaccines

Autor: Lorne A. Babiuk, Georg Widera, Shawn Babiuk, Dorothy M. Middleton, Maria E. Baca-Estrada, Deitmar Rabussay, Marianna Foldvari

Publikováno v: Journal of Biotechnology. 110:1-10

One potential reason for the enhancement of immune responses to DNA vaccines following electroporation is increased gene expression. However, the inflammatory response and accompanying cellular infiltration stimulated by electroporation may also be e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25acbf48c7c135c1c9ca8b49684607bf
https://doi.org/10.1016/j.jbiotec.2004.01.015

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In Vivo and in Vitro Colonization Patterns of AIDA-I–Positive Escherichia Coli Isolates from Piglets with Diarrhea

Autor: Musangu Ngeleka, Dorothy M. Middleton, Jane Pritchard

Publikováno v: Journal of Veterinary Diagnostic Investigation. 16:108-115

Transmission electron microscopy (TEM) was used to characterize the colonization patterns of 3 pathogenic Escherichia coli strains: PD58 and PD149 of the AIDA-I/STb/EAST1 pathotype, serogroup O: ND (not determined), and PD31 of the LT/STb/EAST1 patho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876c54056fa46b23ed3ee688ea86f075
https://doi.org/10.1177/104063870401600203

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Biphasic Lipid Vesicles (Biphasix™) Enhance the Adjuvanticity of CpG Oligonucleotides Following Systemic and Mucosal Administration

Autor: Dorothy M. Middleton, Lorne A. Babiuk, Rolf Hecker, Maria E. Baca-Estrada, Shawn Babiuk, Marianna Foldvari

Publikováno v: Current Drug Delivery. 1:9-15

CpG oligonucleotides (ODNs) are potent mucosal and systemic adjuvants. For practical applications however, improvements in delivery need to be developed. A mouse model was used to determine if the biological activity of CpG ODNs could be enhanced usi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3e7cff12858742f02ba02da898cb12f
https://doi.org/10.2174/1567201043479993

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Isolation and Association of Escherichia Coli AIDA-I/STb, Rather than EAST1 Pathotype, with Diarrhea in Piglets and Antibiotic Sensitivity of Isolates

Autor: Dorothy M. Middleton, Musangu Ngeleka, John M. Fairbrother, Jane Pritchard, Greg D. Appleyard

Publikováno v: Journal of Veterinary Diagnostic Investigation. 15:242-252

To identify emerging Escherichia coli that have the potential to cause diarrhea in pigs, the prevalence of E. coli pathotypes was determined among 170 and 120 isolates from diarrheic and nondiarrheic piglets, respectively. The isolates were tested fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7baea3aa4543a7e0441a3b3c42184ce8
https://doi.org/10.1177/104063870301500305

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Changes in the leucocyte subpopulations of the palatine tonsillar crypt epithelium of pigs in response to Streptococcus suis type 2 infection

Autor: Dorothy M. Middleton, P Willson, J Perez-Casal, Mônica W. S. Salles

Publikováno v: Veterinary Immunology and Immunopathology. 87:51-63

The tonsils are portal of entry and a site of multiplication and persistence for a variety of pathogens, including Streptococcus suis (S. suis), which is a common cause of meningitis, septicemia and arthritis in pigs. Understanding the early changes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc53f1603bb35fbd6e4b3c10264d3a5
https://doi.org/10.1016/s0165-2427(02)00040-5

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Identification of Escherichia coli F4ac-binding proteins in porcine milk fat globule membrane

Autor: Predrag, Novakovic, Yanyun Y, Huang, Betty, Lockerbie, Farshid, Shahriar, John, Kelly, John R, Gordon, Dorothy M, Middleton, Matthew E, Loewen, Beverly A, Kidney, Elemir, Simko

Publikováno v: Canadian journal of veterinary research = Revue canadienne de recherche veterinaire. 79(2)

F4ac-positive enterotoxigenic Escherichia coli (ETEC) must attach to the intestinal mucosa to cause diarrhea in piglets. Prevention of bacterial attachment to the intestinal mucosa is the most effective defense against ETEC-induced diarrhea. Porcine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ebd979dd96efc068f54c235cbcacf873
https://pubmed.ncbi.nlm.nih.gov/25852227

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