Výsledky vyhledávání - "Dorothy J. Margolskee"

Leukotriene D receptor blockade inhibits the immediate and late bronchoconstrictor responses to inhaled antigen in patients with asthma

Autor: Jørgen Bo Rasmussen, Philip Tagari, Vanessa C. Williams, Dorothy J. Margolskee, Karl-Erik Andersson, Lars-Olof Eriksson

Publikováno v: Journal of Allergy and Clinical Immunology. 90:193-201

We have tested the hypothesis that leukotriene D 4 (LTD 4 ) receptor activation is involved in the development of antigen-induced bronchoconstriction. In two studies, patients with asthma received infusions of placebo or MAT-571, a potent and specifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f2b95238b8808df8ebe8bb0c846b8427
https://doi.org/10.1016/0091-6749(92)90071-9

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Oral pharmacokinetics and food interaction of the leukotriene D4 receptor antagonist verlukast

Autor: Thorir D. Bjornsson, Dorothy J. Margolskee, Vanessa C. Williams, Charles C. Lin, Jules I. Schwartz, J. Douglas Rogers, John Y.-K. Hsieh

The influence of dose and food on the pharmacokinetic profile of orally administered verlukast, a leukotriene D4 receptor antagonist, was investigated in 12 healthy male volunteers. This was an open, four-period, single dose, randomised, crossover de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::367bb5177720088543807da69fd19d0c
https://europepmc.org/articles/PMC1364621/

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Urinary LTE4 excretion in antigen-provoked asthmatic patients treated with the inhaled LTD4 antagonist, L-648,051

Autor: Karl-Erik Andersson, J. B. Rasmussen, Dorothy J. Margolskee, Philip Tagari, L.-O. Eriksson, Y. Girard

Publikováno v: Allergy. 47(6)

Leukotriene (LT) E4 represents the major LT metabolite in man, and its urinary excretion can be used as an indirect marker of systemic LTC4 and/or LTD4 synthesis and release. In the present study LTE4 excretion was monitored for 24 h in 12 atopic pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9821904d75222e9d739f4297e9a04156
https://pubmed.ncbi.nlm.nih.gov/1337423

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Bronchodilation with a potent and selective leukotriene D4 (LTD4) receptor antagonist (MK-571) in patients with asthma

Autor: Dorothy J. Margolskee, William W. Busse, Robert K. Bush, Vanessa C. Williams, Joseph N. Gaddy

Publikováno v: The American review of respiratory disease. 146(2)

The sulfidopeptide leukotrienes LTC4, LTD4, and LTE4 can cause airway smooth muscle contraction and have been implicated in the pathophysiology of asthma. MK-571 is a selective, potent LTD4 receptor antagonist that could attenuate airway obstruction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::346c05e1c72bf3b9babfe3563f46fdd3
https://pubmed.ncbi.nlm.nih.gov/1489125

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MK-571, a potent antagonist of leukotriene D4-induced bronchoconstriction in the human

Autor: Marcel E. Van Der Straeten, Johan Kips, Inge De Lepeleire, Guy Joos, Agnes Buntinx, Romain Pauwels, Dorothy J. Margolskee

Publikováno v: The American review of respiratory disease. 144(3 Pt 1)

MK-571 is a novel leukotriene D4/E4 (LTD4/E4) receptor antagonist. The ability of MK-571 to inhibit LTD4-induced bronchoconstriction was examined both in six healthy volunteers and in six asthmatic subjects in a double-blind, placebo-controlled, rand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::360ab8bd0842db833356427888a14d01
https://pubmed.ncbi.nlm.nih.gov/1892302

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Inhibition of exercise-induced bronchoconstriction by MK-571, a potent leukotriene D4-receptor antagonist

Autor: Dorothy J. Margolskee, Jules I. Schwartz, Richard M. Watson, Paul M. O'Byrne, Vanessa C. Williams, Patrick J. Manning

Publikováno v: The New England journal of medicine. 323(25)

Exercise is a common stimulus of bronchoconstriction in subjects with asthma, who also have bronchoconstriction after inhaling the sulfidopeptide leukotriene D4 (LTD4). The purpose of this study was to investigate the importance of LTD4 as a mediator

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47549ae5063d6764bb65267cfd615e4b
https://pubmed.ncbi.nlm.nih.gov/2247109

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