Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Dorothy Hudig"'
Autor:
Lydia Navarrete-Galvan, Michael Guglielmo, Judith Cruz Amaya, Julie Smith-Gagen, Vincent C. Lombardi, Rebecca Merica, Dorothy Hudig
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-13 (2022)
Abstract Background The NK cell line NK-92 and its genetically modified variants are receiving attention as immunotherapies to treat a range of malignancies. However, since NK-92 cells are themselves tumors, they require irradiation prior to transfer
Externí odkaz:
https://doaj.org/article/08b208ea7b0644029d4d0450d419a938
Publikováno v:
Antibodies, Vol 12, Iss 3, p 44 (2023)
Antibody-dependent cell-mediated cytotoxicity (ADCC) by natural killer (NK) lymphocytes eliminates cells infected with viruses. Anti-viral ADCC requires three components: (1) antibody; (2) effector lymphocytes with the Fc-IgG receptor CD16A; and (3)
Externí odkaz:
https://doaj.org/article/2940cea48cc64ab29b95c29f38def1ee
Autor:
Kathryn G. Sterling, Griffin Kutler Dodd, Shatha Alhamdi, Peter G. Asimenios, Ruben K. Dagda, Kenny L. De Meirleir, Dorothy Hudig, Vincent C. Lombardi
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13328 (2022)
Recent advances in next-generation sequencing (NGS) technologies have opened the door to a wellspring of information regarding the composition of the gut microbiota. Leveraging NGS technology, early metagenomic studies revealed that several diseases,
Externí odkaz:
https://doaj.org/article/36e5b3f78c0d4f30a0da2b5715f4e687
Autor:
Jennifer J.-J. Tang, Alexander P. Sung, Michael J. Guglielmo, Lydia Navarrete-Galvan, Doug Redelman, Julie Smith-Gagen, Dorothy Hudig
Publikováno v:
Antibodies, Vol 9, Iss 4, p 54 (2020)
NK cell ADCC supports monoclonal antibody anti-tumor therapies. We investigated serial ADCC and whether it could be predicted by NK phenotypes, including expression of CD16A, CD2 and perforin. CD16A, the NK receptor for antibodies, has AA158 valine o
Externí odkaz:
https://doaj.org/article/3830a81a7c394fcb823aa145c242f095
Antibody-dependent cell-mediated cytotoxicity (ADCC) by natural killer (NK) lymphocytes eliminates cells infected with viruses. Antiviral ADCC requires three components: 1) antibody; 2) effector lymphocytes with the Fc-IgG receptor CD16A; and 3) vira
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::386c2cdeef44a8757fece40ea87ead4d
https://doi.org/10.20944/preprints202305.1841.v1
https://doi.org/10.20944/preprints202305.1841.v1
Autor:
Lydia T Navarrete-Galvan, Michael Guglielmo, Judith Cruz Amaya, Julie Smith-Gagen, Vincent C. Lombardi, Rebecca Merica, Dorothy Hudig
Publikováno v:
Journal of translational medicine. 20(1)
BackgroundThe NK cell line NK-92 and its genetically modified variants are receiving attention as immunotherapies to treat a range of malignancies. However, since NK-92 cells are themselves tumors, they require irradiation prior to transfer and are p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd4c33aedd7c0974079a175288815dc0
https://pubmed.ncbi.nlm.nih.gov/35366943
https://pubmed.ncbi.nlm.nih.gov/35366943
Autor:
Dorothy Hudig, Lydia Navarrete-Galvan, Jennifer J.-J. Tang, Alexander P. Sung, Lucinda Bateman, Doug Redelman, Julie Smith-Gagen, Michael J. Guglielmo
Publikováno v:
Fatigue
BACKGROUND: Chronic fatigue syndrome (CFS) is an illness of unknown origin that may have familial risks. Low natural killer (NK) lymphocyte activity was proposed as a risk for familial CFS in 1998. Since then, there have been many studies of NK lymph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27c34898fe5063335a5d949cbb0b9bc3
https://pubmed.ncbi.nlm.nih.gov/33777500
https://pubmed.ncbi.nlm.nih.gov/33777500
Autor:
Judith B Cruz Amaya, Lydia T Navarrete-Galvan, Vincent C Lombardi, Matthew Isom, Julie Smith-Gagen, Dorothy Hudig
Publikováno v:
The Journal of Immunology. 208:54.20-54.20
Irradiation damages both proteins and DNA, which reduces the cytotoxicity of NK-92 cells as well as preventing their growth and engraftment when used for adoptive immunotherapies of cancer. We evaluated the DNA topoisomerase inhibitor irinotecan (CPT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4370891a178fca1584265145719f5b18
https://doi.org/10.4049/jimmunol.208.supp.54.20
https://doi.org/10.4049/jimmunol.208.supp.54.20
Autor:
Lydia T Navarrete-Galvan, Michael Guglielmo, Judith Cruz Amaya, Rebecca Merica, Julie Smith-Gagen, Vincent C Lombardi, Dorothy Hudig
Publikováno v:
The Journal of Immunology. 208:62.03-62.03
Adoptively transferred NK-92 cells and genetically modified variants must undergo irradiation to prevent proliferation, since NK-92 cells are themselves tumors. This malignant quality also makes NK-92 cells susceptible to attack by patients’ NK cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e4d931a30f2c27d866db917e252a1ec
https://doi.org/10.4049/jimmunol.208.supp.62.03
https://doi.org/10.4049/jimmunol.208.supp.62.03
Autor:
Julie Smith-Gagen, Michael J. Guglielmo, Doug Redelman, Jennifer J.-J. Tang, Alexander P. Sung, Lydia Navarrete-Galvan, Dorothy Hudig
Publikováno v:
Antibodies
Volume 9
Issue 4
Antibodies, Vol 9, Iss 54, p 54 (2020)
Volume 9
Issue 4
Antibodies, Vol 9, Iss 54, p 54 (2020)
NK cell ADCC supports monoclonal antibody anti-tumor therapies. We investigated serial ADCC and whether it could be predicted by NK phenotypes, including expression of CD16A, CD2 and perforin. CD16A, the NK receptor for antibodies, has AA158 valine o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f9ac739213bfafe20ee4fed19603a55