Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Dorothy H Slentz"'
Autor:
William E Kraus, Deborah M Muoio, Robert Stevens, Damian Craig, James R Bain, Elizabeth Grass, Carol Haynes, Lydia Kwee, Xuejun Qin, Dorothy H Slentz, Deidre Krupp, Michael Muehlbauer, Elizabeth R Hauser, Simon G Gregory, Christopher B Newgard, Svati H Shah
Publikováno v:
PLoS Genetics, Vol 11, Iss 11, p e1005553 (2015)
Levels of certain circulating short-chain dicarboxylacylcarnitine (SCDA), long-chain dicarboxylacylcarnitine (LCDA) and medium chain acylcarnitine (MCA) metabolites are heritable and predict cardiovascular disease (CVD) events. Little is known about
Externí odkaz:
https://doaj.org/article/71d65ad2e8ba483ea543b1b239ab3bdc
Autor:
Maria J. Torres, Xu Zhang, Dorothy H. Slentz, Timothy R. Koves, Hailee Patel, George A. Truskey, Deborah M. Muoio
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105189- (2022)
Summary: Two prominent frontline breast cancer (BC) chemotherapies commonly used in combination, doxorubicin (DOX) and docetaxel (TAX), are associated with long-lasting cardiometabolic and musculoskeletal side effects. Whereas DOX has been linked to
Externí odkaz:
https://doaj.org/article/c8925c5ae8554c5e8f3c1c0d1e770e8d
Autor:
Ashley S. Williams, Timothy R. Koves, Yasminye D. Pettway, James A. Draper, Dorothy H. Slentz, Paul A. Grimsrud, Olga R. Ilkayeva, Deborah M. Muoio
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103635- (2022)
Summary: Nicotinamide riboside supplements (NRS) have been touted as a nutraceutical that promotes cardiometabolic and musculoskeletal health by enhancing nicotinamide adenine dinucleotide (NAD+) biosynthesis, mitochondrial function, and/or the activ
Externí odkaz:
https://doaj.org/article/613c482ce3f74ec8b3a7c71691a2c885
Autor:
Timothy R. Koves, Guo-Fang Zhang, Michael T. Davidson, Alec B. Chaves, Scott B. Crown, Jordan M. Johnson, Dorothy H. Slentz, Paul A. Grimsrud, Deborah M. Muoio
Publikováno v:
Cell Metabolism.
Autor:
Sarah E. Seiler, Ola J. Martin, Robert C. Noland, Dorothy H. Slentz, Karen L. DeBalsi, Olga R. Ilkayeva, Jie An, Christopher B. Newgard, Timothy R. Koves, Deborah M. Muoio
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 4, Pp 635-644 (2014)
Carnitine acetyltransferase (CrAT) is a mitochondrial matrix enzyme that catalyzes the interconversion of acetyl-CoA and acetylcarnitine. Emerging evidence suggests that this enzyme functions as a positive regulator of total body glucose tolerance an
Externí odkaz:
https://doaj.org/article/4ee4bb6ffe9b483faa5be0ed9c3553fb
Autor:
Ashley S. Williams, Timothy R. Koves, Yasminye D. Pettway, James A. Draper, Dorothy H. Slentz, Paul A. Grimsrud, Olga R. Ilkayeva, Deborah M. Muoio
Publikováno v:
iScience
iScience, Vol 25, Iss 1, Pp 103635-(2022)
iScience, Vol 25, Iss 1, Pp 103635-(2022)
Summary Nicotinamide riboside supplements (NRS) have been touted as a nutraceutical that promotes cardiometabolic and musculoskeletal health by enhancing nicotinamide adenine dinucleotide (NAD+) biosynthesis, mitochondrial function, and/or the activi
Autor:
Maria J. Torres, Xu Zhang, Dorothy H. Slentz, Timothy R. Koves, Hailee Patel, George A. Truskey, Deborah M. Muoio
Publikováno v:
iScience. 25(10)
Two prominent frontline breast cancer (BC) chemotherapies commonly used in combination, doxorubicin (DOX) and docetaxel (TAX), are associated with long-lasting cardiometabolic and musculoskeletal side effects. Whereas DOX has been linked to mitochond
Autor:
Maria J Torres Alcalde, Timothy R. Koves, Dorothy H. Slentz, Deborah M. Muoio, Xu Zang, George A. Truskey
Publikováno v:
Circulation. 139
Taxanes (i.e. docetaxel, (TAX)) comprise the first line-treatment for breast cancer (BC), mostly in combination with anthracyclines like doxorubicin (DOX). The efficacy of these drugs as antineoplastic agents has helped to boost 10-year survival rate
Autor:
Deborah M. Muoio, Scott B. Crown, Louise Lantier, Michael T. Davidson, Paul A. Grimsrud, James A. Draper, Tara M. Narowski, Ashley S. Williams, Dorothy H. Slentz, Kelsey H. Fisher-Wellman, Timothy R. Koves, Maria J. Torres, David H. Wasserman
Publikováno v:
Cell Metab
This study sought to examine the functional significance of mitochondrial protein acetylation using a double knockout (DKO) mouse model harboring muscle-specific deficits in acetyl CoA buffering and lysine deacetylation, due to genetic ablation of ca
Autor:
Daniel P. Kelly, Michael T. Davidson, Gregory R. Wagner, Paul A. Grimsrud, Dorothy H. Slentz, David P. Olson, J. Will Thompson, Mathew D. Hirschey, Olga Ilkayeva, Deborah M. Muoio, James A. Draper, Tara M. Narowski, Rami Najjar, Timothy R. Koves, Kelsey H. Fisher-Wellman, Robert Stevens, Ashley S. Williams
Publikováno v:
Cell reports
Cell Reports, Vol 26, Iss 6, Pp 1557-1572.e8 (2019)
Cell Reports, Vol 26, Iss 6, Pp 1557-1572.e8 (2019)
SUMMARY Acyl CoA metabolites derived from the catabolism of carbon fuels can react with lysine residues of mitochondrial proteins, giving rise to a large family of post-translational modifications (PTMs). Mass spectrometry-based detection of thousand