Transcriptional adaptation of Mycobacterium tuberculosis that survives prolonged multi-drug treatment in mice

Autor: Elizabeth A. Wynn, Christian Dide-Agossou, Matthew Reichlen, Karen Rossmassler, Reem Al Mubarak, Justin J. Reid, Samuel T. Tabor, Sarah E. M. Born, Monica R. Ransom, Rebecca M. Davidson, Kendra N. Walton, Jeanne B. Benoit, Amanda Hoppers, Dorothy E. Loy, Allison A. Bauman, Lisa M. Massoudi, Gregory Dolganov, Michael Strong, Payam Nahid, Martin I. Voskuil, Gregory T. Robertson, Camille M. Moore, Nicholas D. Walter

Publikováno v: mBio, Vol 14, Iss 6 (2023)

ABSTRACTTo address the ongoing global tuberculosis crisis, there is a need for shorter, more effective treatments. A major reason why tuberculosis requires prolonged treatment is that, following a short initial phase of rapid killing, the residual My

Externí odkaz: https://doaj.org/article/ecb358dada2541348c703fab9ae27766

Wild bonobos host geographically restricted malaria parasites including a putative new Laverania species

Autor: Weimin Liu, Scott Sherrill-Mix, Gerald H. Learn, Erik J. Scully, Yingying Li, Alexa N. Avitto, Dorothy E. Loy, Abigail P. Lauder, Sesh A. Sundararaman, Lindsey J. Plenderleith, Jean-Bosco N. Ndjango, Alexander V. Georgiev, Steve Ahuka-Mundeke, Martine Peeters, Paco Bertolani, Jef Dupain, Cintia Garai, John A. Hart, Terese B. Hart, George M. Shaw, Paul M. Sharp, Beatrice H. Hahn

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)

Unlike chimpanzees and gorillas, bonobos have not been found infected by malaria parasites in the wild. Here, Liu et al. report more thorough survey and sequencing results showing that bonobos host malaria parasites, including a yet-unknown species,

Externí odkaz: https://doaj.org/article/dcde71d74a4544ac9856a87833ed478f

Reply to Forni et al., 'Multiple Selected Changes May Modulate the Molecular Interaction between Laverania RH5 and Primate Basigin'

Autor: Lindsey J. Plenderleith, Weimin Liu, Oscar A. MacLean, Yingying Li, Dorothy E. Loy, Sesh A. Sundararaman, Frederic Bibollet-Ruche, Gerald H. Learn, Beatrice H. Hahn, Paul M. Sharp

Publikováno v: mBio, Vol 9, Iss 3 (2018)

Externí odkaz: https://doaj.org/article/0d415e6603a54ed2aaf1982ee6281271

Selective Whole-Genome Amplification Is a Robust Method That Enables Scalable Whole-Genome Sequencing of Plasmodium vivax from Unprocessed Clinical Samples

Autor: Annie N. Cowell, Dorothy E. Loy, Sesh A. Sundararaman, Hugo Valdivia, Kathleen Fisch, Andres G. Lescano, G. Christian Baldeviano, Salomon Durand, Vince Gerbasi, Colin J. Sutherland, Debbie Nolder, Joseph M. Vinetz, Beatrice H. Hahn, Elizabeth A. Winzeler

Publikováno v: mBio, Vol 8, Iss 1 (2017)

ABSTRACT Whole-genome sequencing (WGS) of microbial pathogens from clinical samples is a highly sensitive tool used to gain a deeper understanding of the biology, epidemiology, and drug resistance mechanisms of many infections. However, WGS of organi

Externí odkaz: https://doaj.org/article/06471cd2d0064efd87efc3184399387a

CD4 receptor diversity represents an ancient protection mechanism against primate lentiviruses

Autor: Preston A. Marx, William J. Kohler, Sandrine François-Souquiere, Alexander V. Georgiev, Weimin Liu, Ronnie M. Russell, Stephanie Trimboli, Scott Sherrill-Mix, Ronald G. Collman, Beatrice H. Hahn, Paul M. Sharp, Alex K. Piel, Paco Bertolani, Martine Peeters, Dorothy E. Loy, Marcos V. P. Gondim, Ahidjo Ayouba, Amandine Esteban, George M. Shaw, Lindsey J. Plenderleith, Volker Sommer, Frederic Bibollet-Ruche, Jesse Connell, Terese B. Hart, Fiona A. Stewart, Andrew G. Smith, Vanessa M. Hirsch, William M. Switzer, John Hart, Alexa N. Avitto, Katherine S. Wetzel, Yingying Li, Richard A. Miller

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Russell, R M, Bibollet-Ruche, F, Liu, W, Sherrill-Mix, S, Li, Y, Connell, J, Loy, D E, Trimboli, S, Smith, A G, Avitto, A N, Gondim, M V P, Plenderleith, L J, Wetzel, K S, Collman, R G, Ayouba, A, Esteban, A, Peeters, M, Kohler, W J, Miller, R A, François-Souquiere, S, Switzer, W M, Hirsch, V M, Marx, P A, Piel, A K, Stewart, F A, Georgiev, A V, Sommer, V, Bertolani, P, Hart, J A, Hart, T B, Shaw, G M, Sharp, P M & Hahn, B H 2021, ' CD4 receptor diversity represents an ancient protection mechanism against primate lentiviruses ', Proceedings of the National Academy of Sciences, vol. 118, no. 13, e2025914118 . https://doi.org/10.1073/pnas.2025914118

Significance The CD4 protein of primates has undergone rapid diversification, but the reasons for this remain unknown. Here we show that within-species diversity of the HIV/simian immunodeficiency virus (SIV) envelope (Env) binding (D1) domain is com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdc8f73fc10197a926b8ef57f87f72c6
https://pubmed.ncbi.nlm.nih.gov/33771926