Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Dorothy Agnes Theodore"'
Autor:
Pedro A. Piedra, Dorothy Agnes Theodore, Robert Jordan, Sangi Michael, Michel Perron, Kirsten M. Stray, Eugene J. Eisenberg, Richard L. Mackman, Brian E. Gilbert, Geoffery L. Toms, Gary Lee, April Kinkade, Tomas Cihlar
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:1264-1273
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections in infants and young children. In addition, RSV causes significant morbidity and mortality in hospitalized elderly and immunocompromised patients. Currently, o
Autor:
Anne Carey, Kirsten M. Stray, Brian E. Gilbert, Pedro A. Piedra, Dorothy Agnes Theodore, Kerim Babaoglu, Jay P. Parrish, Manoj C. Desai, Lijun Zhang, April Kinkade, Hai Yang, Dharmaraj Samuel, Oliver L. Saunders, Constantine G. Boojamra, Jaclyn Hayes, Robert Jordan, Sangi Michael, Eugene J. Eisenberg, David Sperandio, Dustin Siegel, Richard L. Mackman, Hui Hon Chung, Quynh Iwata, Tomas Cihlar, Michel Perron, Gary Lee, Robert G. Strickley
Publikováno v:
Journal of Medicinal Chemistry. 58:1630-1643
GS-5806 is a novel, orally bioavailable RSV fusion inhibitor discovered following a lead optimization campaign on a screening hit. The oral absorption properties were optimized by converting to the pyrazolo[1,5-a]-pyrimidine heterocycle, while potenc