Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Dorothy A. Sims"'
Autor:
Elizabeth England, D. Gareth Rees, Ian Christopher Scott, Sara Carmen, Denice T. Y. Chan, Catherine E. Chaillan Huntington, Kirsty F. Houslay, Teodor Erngren, Mark Penney, Jayesh B. Majithiya, Laura Rapley, Dorothy A. Sims, Claire Hollins, Elizabeth C. Hinchy, Martin D. Strain, Benjamin P. Kemp, Dominic J. Corkill, Richard D. May, Katherine A. Vousden, Robin J. Butler, Tomas Mustelin, Tristan J. Vaughan, David C. Lowe, Caroline Colley, E. Suzanne Cohen
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Interleukin (IL)-33 is a broad-acting alarmin cytokine that can drive inflammatory responses following tissue damage or infection and is a promising target for treatment of inflammatory disease. Here, we describe the identification of tozora
Externí odkaz:
https://doaj.org/article/4d1e1f2da3f148aa85e1df6a32f0ef69
Autor:
Elizabeth England, D. Gareth Rees, Ian Christopher Scott, Sara Carmen, Denice T. Y. Chan, Catherine E. Chaillan Huntington, Kirsty F. Houslay, Teodor Erngren, Mark Penney, Jayesh B. Majithiya, Laura Rapley, Dorothy A. Sims, Claire Hollins, Elizabeth C. Hinchy, Martin D. Strain, Benjamin P. Kemp, Dominic J. Corkill, Richard D. May, Katherine A. Vousden, Robin J. Butler, Tomas Mustelin, Tristan J. Vaughan, David C. Lowe, Caroline Colley, E. Suzanne Cohen
Interleukin (IL)-33 is a broad-acting alarmin cytokine that can drive inflammatory responses following tissue damage or infection and is a promising target for treatment of inflammatory disease. Here, we describe the identification of tozorakimab (ME
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2623b7a64721c16cead1782c6553f513
https://doi.org/10.1101/2023.02.28.527262
https://doi.org/10.1101/2023.02.28.527262
Autor:
Inna Vainshtein, Matthew McCourt, C Drinkwater, Trevor Wilkinson, L Roskos, C Matthews, Mark A Sleeman, Paula Harrison, Dorothy A. Sims, Meina Liang, Bo Wang, Cohen Emma S, Ralph Minter, Lutz Jermutus, G Rees, I.K. Anderson, Phillip Monk, Andrew D. Nash, Laura Eghobamien, L Fabri
Publikováno v:
British Journal of Pharmacology. 168:200-211
Background and Purpose For antibody therapies against receptor targets, in vivo outcomes can be difficult to predict because of target-mediated clearance or antigen ‘sink’ effects. The purpose of this work was to engineer an antibody to the GM-CS
Autor:
Dorothy A. Sims, Richard D. May, Tomas Mustelin, Joanne Woods, David C. Lowe, Denice T. Y. Chan, Laura Rapley, Benjamin Kemp, Matthew A. Sleeman, Nicholas J. Bond, Christel Séguy Veyssier, Liz Flavell, Katherine A. Vousden, Tristan J. Vaughan, Sara Carmen, Kevin J. Embrey, Overed-Sayer Catherine L, Catherine E. Huntington, Christopher E. Brightling, Michael R. Snaith, Bojana Popovic, D. Gareth Rees, Strain Martin D, Ian C. Scott, E. Suzanne Cohen, Jianqing Xu, Dominic J. Corkill, Jayesh B. Majithiya, Daniel R. Higazi, Elizabeth England, Robin Butler
Publikováno v:
Nature Communications
In response to infections and irritants, the respiratory epithelium releases the alarmin interleukin (IL)-33 to elicit a rapid immune response. However, little is known about the regulation of IL-33 following its release. Here we report that the biol
Autor:
Dorothy A. Sims, Matthew A. Sleeman, Christopher E. Brightling, Jayesh B. Majithiya, Laura Rapley, Suzanne Cohen, Robin Butler, Benjamin Kemp, Ian C. Scott, Tomas Mustelin, Richard D. May, Daniel R. Higazi, Nicholas J. Bond, Dominic J. Corkill
Publikováno v:
5.3 Allergy and Immunology.
Background: In response to infections and irritants, the bronchial epithelium releases the alarmin interleukin(IL)-33 to elicit a rapid immune response. Regulation of IL-33 following release from the cell is poorly understood. Here we characterise th
Publikováno v:
Journal of the Association for Laboratory Automation. 10:98-101
rotein stability is a standard metric to study therelationship between protein sequence and stability.Here we show that laboratory automation can be used toincrease both the precision and the throughput of stabilitymeasurements. A laboratory automati
Publikováno v:
Biochemistry. 42:7594-7603
Statistical modeling provides the mathematics to use data from large numbers of mutant proteins to generate information about hypotheses concerning protein structure not easily obtained from anecdotal studies on small numbers of mutants. Here we use
Autor:
Sophia N. Karagiannis, Sofia Persdotter, Emmanuel Briend, Siobhan O'Brien, Richard D. May, Phillip Monk, Helena Ekdahl, Karin Von Wachenfeldt, E. Suzanne Cohen, Hongwei Guo, Sarah Oakley, Dorothy A. Sims, Mats Carlsson, D. Gareth Rees, Hannah J. Gould, Trevor Wilkinson, Bing Wang, Tristan J. Vaughan, Claire Dobson, Feenagh Keyes, Elizabeth England, I.K. Anderson, Chris Lloyd, Helena Käck, Robin Butler, Per-Olof Fredrik Eriksson
Publikováno v:
Europe PubMed Central
The critical role played by IgE in allergic asthma is well-documented and clinically precedented, but some patients in whom IgE neutralization may still offer clinical benefit are excluded from treatment with the existing anti-IgE therapy, omalizumab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a8dcad4748d60086cf9976aa5e39cc
https://europepmc.org/articles/PMC7098617/
https://europepmc.org/articles/PMC7098617/
Publikováno v:
NeuroRehabilitation. 11:41-49
Autor:
Matthew J. Robinson, I.K. Anderson, E. S. Cohen, Richard D. May, Benjamin Kemp, Dorothy A. Sims
Publikováno v:
C31. INTERLEUKIN-33 BIOLOGY.