Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Dorothy A. Hanck"'
Publikováno v:
Biophysical Journal. 109(11):2277-2286
Voltage-gated sodium (NaV) channels contain an α-subunit incorporating the channel’s pore and gating machinery composed of four homologous domains (DI–DIV), with a pore domain formed by the S5 and S6 segments and a voltage-sensor domain formed b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0da9394bc9e9d38aa52f4e0e8d649a4
Autor:
Paul Vezina, Dorothy A. Hanck, Jessica A. Loweth, Stacy Herrera, Abraham A. Palmer, Elena Nikitina, Nancy Bubula, Dongdong Li
Publikováno v:
Journal of Neurochemistry. 118:237-247
The closely related δ and e isoforms of the serine/threonine protein kinase casein kinase 1 (Csnk1) have been implicated in the generation of psychostimulant-induced behaviors. In this study, we show that Csnk1δ/e produces its effects on behavior b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9f11a0e0aa14f2a312df715a95fb158
https://doi.org/10.1111/j.1471-4159.2011.07308.x
https://doi.org/10.1111/j.1471-4159.2011.07308.x
Publikováno v:
Molecular Pharmacology. 79:411-419
Verapamil is a prototypical phenylalkylamine (PAA), and it was the first calcium channel blocker to be used clinically. It tonically blocks L-type channels in the inner pore with micromolar affinity, and its affinity increases at depolarized membrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6d08f585a1133875004da6cd8fcd2bd
https://doi.org/10.1124/mol.110.069492
https://doi.org/10.1124/mol.110.069492
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 461:91-97
Previous studies have shown that lidocaine and other local anesthetic drugs (LAs) cause use-dependent block of sodium current (I (Na)), i.e., block that increases with membrane depolarization by allosteric coupling between drug binding in the inner p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f095e17cc1688a36b18cfd689e2dfc5f
https://doi.org/10.1007/s00424-010-0894-1
https://doi.org/10.1007/s00424-010-0894-1
Publikováno v:
Trends in Cardiovascular Medicine. 20:16-21
Class I cardiac antiarrhythmic drugs, for example, lidocaine, mexiletine, flecainide, quinidine, and procainamide, continue to play an important role in the therapy for cardiac arrhythmias because of the presence of use-dependent block. Lidocaine, as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f407cf56b1641210458d00e4758f6872
https://doi.org/10.1016/j.tcm.2010.03.002
https://doi.org/10.1016/j.tcm.2010.03.002
Autor:
Viviana M. Berthoud, John W. Kyle, Peter J. Minogue, Josh W. Kurutz, Michael Greenspan, Dorothy A. Hanck, Eric C. Beyer
Publikováno v:
Journal of Biological Chemistry. 284:20418-20427
The cytoplasmic N-terminal domain of connexins has been implicated in multiple aspects of gap junction function, including connexin trafficking/assembly and channel gating. A synthetic peptide corresponding to the first 23 amino acids of human connex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::774734240216789adb8e65c96c87df36
https://doi.org/10.1074/jbc.m109.016907
https://doi.org/10.1074/jbc.m109.016907
Publikováno v:
Toxicon. 52:489-500
The peptide toxin ProTxII, recently isolated from the venom of the tarantula spider Thrixopelma pruriens, modifies gating in voltage-gated Na+ and Ca2+ channels. ProTxII is distinct from other known Na+ channel gating modifier toxins in that it affec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa328324d1f675f7f692af509cd34d4e
https://doi.org/10.1016/j.toxicon.2008.06.023
https://doi.org/10.1016/j.toxicon.2008.06.023
The Relationship between Single-Channel and Whole-Cell Conductance in the T-type Ca2+ Channel CaV3.1
Autor:
Dorothy A. Hanck, Katie C. Bittner
Publikováno v:
Biophysical Journal. 95(2):931-941
In T-type Ca(2+) channels, macroscopic I(Ba) is usually smaller than I(Ca), but at high Ca(2+) and Ba(2+), single-channel conductance (gamma) is equal. We investigated gamma as a function of divalent concentration and compared it to macroscopic curre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82224d1b1a0fd1adebfe13f38167dda1
Autor:
Dorothy A. Hanck, Michael F. Sheets
Publikováno v:
The Journal of Physiology. 582:317-334
The anti-arrhythmic drug lidocaine has been shown to have a lower affinity for block of voltage-gated sodium channels at hyperpolarized potentials compared to depolarized potentials. Concomitantly, lidocaine reduces maximum gating charge (Qmax) by 40
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e87157b6f9dbddce2f256e54063f74ef
https://doi.org/10.1113/jphysiol.2007.134262
https://doi.org/10.1113/jphysiol.2007.134262
Autor:
Megan M. McNulty, Ravi D. Shah, Gabrielle B. Edgerton, Gregory M. Lipkind, Dorothy A. Hanck, Harry A. Fozzard
Publikováno v:
The Journal of Physiology. 581:741-755
Our homology molecular model of the open/inactivated state of the Na+ channel pore predicts, based on extensive mutagenesis data, that the local anaesthetic lidocaine docks eccentrically below the selectivity filter, such that physical occlusion is i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5641a357f124c775b28d4b7309b62566
https://doi.org/10.1113/jphysiol.2007.130161
https://doi.org/10.1113/jphysiol.2007.130161