Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Dorothy A Kleinert"'
Autor:
Laura Breda, Carla Casu, Sara Gardenghi, Nicoletta Bianchi, Luca Cartegni, Mohandas Narla, Karina Yazdanbakhsh, Marco Musso, Deepa Manwani, Jane Little, Lawrence B Gardner, Dorothy A Kleinert, Eugenia Prus, Eitan Fibach, Robert W Grady, Patricia J Giardina, Roberto Gambari, Stefano Rivella
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32345 (2012)
Preclinical and clinical studies demonstrate the feasibility of treating β-thalassemia and Sickle Cell Disease (SCD) by lentiviral-mediated transfer of the human β-globin gene. However, previous studies have not addressed whether the ability of len
Externí odkaz:
https://doaj.org/article/472254d68557495b9619e90809e22289
Publikováno v:
Journal of the American Association of Nurse Practitioners. 32:45-51
Background The role of the pediatric nurse practitioner (PNP) has changed since its inception over 50 years ago. Pediatric nurse practitioner practice has evolved from providing outpatient primary care to children to providing complex care in the acu
Autor:
Robert W. Grady, Renzo Galanello, Rachel E. Randolph, Dorothy A. Kleinert, Carlo Dessi, Patricia J. Giardina
Publikováno v:
Haematologica, Vol 98, Iss 1 (2013)
Patients with β-thalassemia require iron chelation therapy to protect against progressive iron overload and non-transferrin-bound iron. Some patients fail to respond adequately to deferoxamine and deferasirox monotherapy while others have side effec
Externí odkaz:
https://doaj.org/article/b74d058b039c474ba9fc9bedc9e56537
Autor:
Sujit Sheth, Dana Clark, Maria Karas, Cheryl Mensah, Dorothy A. Kleinert, Joy Gelbman, Inna Landres
Publikováno v:
American Journal of Obstetrics and Gynecology. 224:S234
Publikováno v:
Transfusion Medicine. 26:186-194
SUMMARY Background Life expectancy of patients with transfusion-dependent thalassemias has increased with the development of improved treatment over the last few decades. However, β-thalassemia disorder still has considerable lifetime treatment dema
Autor:
Diana Degtyaryova, Dorothy A. Kleinert, Cheryl Goss, Melissa M. Cushing, Patricia J. Giardina, Sujit Sheth
Publikováno v:
Transfusion. 54:1773-1781
Background In the absence of curative treatment, such as stem cell transplant, regular transfusions remain the mainstay of therapy for individuals with thalassemia major, a syndrome that results from marked ineffective erythropoiesis and the resultan
Publikováno v:
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis. 54(2)
Objective The objective of this study was to describe complement activation in hemostatic and pathologic states of coagulation and in the acquired and congenital hemolytic anemias. Methods and Results We review published and emerging data on the invo
Autor:
Renzo Galanello, Carlo Dessì, Robert W. Grady, Rachel Randolph, Patricia J. Giardina, Dorothy A. Kleinert
Publikováno v:
Haematologica. 98:129-135
Patients with β-thalassemia require iron chelation therapy to protect against progressive iron overload and non-transferrin-bound iron. Some patients fail to respond adequately to deferoxamine and deferasirox monotherapy while others have side effec
Autor:
Dru Foote, Alexis A. Thompson, Yan Xu, Patricia J. Giardina, Robert Yamashita, Janet L. Kwiatkowski, Charles T. Quinn, Leann Schilling, Lauren Mednick, Shuli Yu, Vivekanandan Thayalasuthan, Dorothy A. Kleinert, John B. Porter, Felicia Trachtenberg, Ellis J. Neufeld
Publikováno v:
American Journal of Hematology. 85:802-805
Thalassemia is an inherited blood disorder that requires lifelong adherence to a complicated and burdensome medical regimen which could potentially impact emotional functioning of patients. The importance of understanding and promoting healthy emotio
Autor:
Laura Casula, Irene Mancini, Carla Casu, Dorothy A. Kleinert, Patricia J. Giardina, Luca Cartegni, Roberto Gambari, Stefano Rivella, Eitan Fibach, Laura Breda
Publikováno v:
Annals of the New York Academy of Sciences. 1202:134-140
Lentiviral-mediated beta-globin gene transfer successfully treated beta-thalassemic mice. Based on this result, clinical trials were initiated. To date, however, no study has investigated the efficacy of gene therapy in relation to the nature of the