Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Dorothy, Beckett"'
Autor:
Erik H. Klontz, Chao Li, Kyle Kihn, James K. Fields, Dorothy Beckett, Greg A. Snyder, Patrick L. Wintrode, Daniel Deredge, Lai-Xi Wang, Eric J. Sundberg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
AlfC transfucosidase is used to modulate fucosylation of glycans decorating monoclonal antibodies. Herein, structural and biophysical characterization reveals the enzymatic mechanism of AlfC and a blueprint for the design of AlfC mutants with novel s
Externí odkaz:
https://doaj.org/article/9a30450512214f37b47bbcf6f541a3c3
Autor:
Erik Klontz, Juliet O. Obi, Yajing Wang, Gabrielle Glendening, Jahid Carr, Constantine Tsibouris, Sahthi Buddula, Shreeram Nallar, Alexei S. Soares, Dorothy Beckett, Jasmina S. Redzic, Elan Eisenmesser, Cheyenne Palm, Katrina Schmidt, Alexis H. Scudder, Trinity Obiorah, Kow Essuman, Jeffrey Milbrandt, Aaron Diantonio, Krishanu Ray, Daniel Deredge, M LD. Snyder, Greg A. Snyder
Toll-like and Interleukin-1/18 receptor resistance (TIR) domain-containing proteins function as important signaling and immune regulatory molecules. TIR domain-containing proteins identified in eukaryotic and prokaryotic species also exhibit NAD+ hyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95374451370e60151b3cff10b9ddcf36
https://doi.org/10.1101/2023.05.19.541320
https://doi.org/10.1101/2023.05.19.541320
Autor:
Sandra Postel, Daniel Deredge, Daniel A Bonsor, Xiong Yu, Kay Diederichs, Saskia Helmsing, Aviv Vromen, Assaf Friedler, Michael Hust, Edward H Egelman, Dorothy Beckett, Patrick L Wintrode, Eric J Sundberg
Publikováno v:
eLife, Vol 5 (2016)
Flagella are crucial for bacterial motility and pathogenesis. The flagellar capping protein (FliD) regulates filament assembly by chaperoning and sorting flagellin (FliC) proteins after they traverse the hollow filament and exit the growing flagellum
Externí odkaz:
https://doaj.org/article/bee7c0a8aa6d4f5a84b1d0eee2a39ce4
Autor:
Silvina Matysiak, Gregory S. Custer, Riya Samanta, Dorothy Beckett, Christopher Look, Jingheng Wang
Publikováno v:
Biochemistry
In allostery, a signal from one site in a protein is transmitted to a second site to alter its function. Due to its ubiquity in biology and the potential for its exploitation in drug and protein design, the molecular basis of allosteric communication
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68fbdff7af073a6794afe84b0646f5fb
https://doi.org/10.1021/acs.biochem.9b01006
https://doi.org/10.1021/acs.biochem.9b01006
Publikováno v:
The Journal of Chemical Physics. 158:085104
Despite more than a century of study, consensus on the molecular basis of allostery remains elusive. A comparison of allosteric and non-allosteric members of a protein family can shed light on this important regulatory mechanism, and the bacterial bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb1d859b1dc293d95a739a7a1d72e198
https://doi.org/10.1063/5.0136010
https://doi.org/10.1063/5.0136010
Autor:
Daniel Deredge, Lai-Xi Wang, Dorothy Beckett, Greg A. Snyder, James K. Fields, Chao Li, Eric J. Sundberg, Kyle C. Kihn, Patrick L. Wintrode, Erik H. Klontz
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Fucosylation is important for the function of many proteins with biotechnical and medical applications. Alpha-fucosidases comprise a large enzyme family that recognizes fucosylated substrates with diverse α-linkages on these proteins. Lactobacillus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d25dd26979c865dcf929d22016baefd4
https://doi.org/10.1038/s41467-020-20044-z
https://doi.org/10.1038/s41467-020-20044-z
Publikováno v:
Biochemistry. 57:1119-1129
Small molecules regulate transcription in both eukaryotes and prokaryotes by either enhancing or repressing assembly of transcription regulatory complexes. For allosteric transcription repressors, superrepressor mutants can exhibit increased sensitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1279188c2cee95dee3bd5e8af5cee385
https://doi.org/10.1021/acs.biochem.7b01122
https://doi.org/10.1021/acs.biochem.7b01122
Autor:
Dorothy Beckett, Jingheng Wang
Publikováno v:
Protein Science. 26:1564-1573
Class II bifunctional biotin protein ligases (BirA), which catalyze post-translational biotinylation and repress transcription initiation, are broadly distributed in eubacteria and archaea. However, it is unclear if these proteins all share the same
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3c5000ad0584ffaf5d5b7474ae859fa
https://doi.org/10.1002/pro.3182
https://doi.org/10.1002/pro.3182
Autor:
Heather M. Neu, Christopher Peralta, Paul T. Wilder, Braden M. Roth, Sianny Christanti, Danya Ben-Hail, Amedee des Georges, Mary E. Cook, Sarah L. J. Michel, Richard R. Rustandi, Xingjian Xu, Edwin Pozharski, Catherine Lancaster, Thomas E. Cleveland, John W. Loughney, Jessica W. Olson, Alexander Grishaev, David J. Weber, Raquel Godoy-Ruiz, Dorothy Beckett, Alex D. MacKerell, Kaylin A. Adipietro, Wenbo Yu, Kristen M. Varney, Adam Kristopeit
TargetingClostridium difficileinfection (CDI) is challenging because treatment options are limited, and high recurrence rates are common. One reason for this is that hypervirulent CDI often has a binary toxin termed theC. difficiletoxin (CDT), in add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca4dbdd79ce3486ec0bdcce30e623d8
Publikováno v:
Biophysical Journal. 120:189a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4f0f880348d304eed9aa8abf543e08b
https://doi.org/10.1016/j.bpj.2020.11.1303
https://doi.org/10.1016/j.bpj.2020.11.1303