Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Dorothee Childs"'
Autor:
Marcin Luzarowski, Rubén Vicente, Andrei Kiselev, Mateusz Wagner, Dennis Schlossarek, Alexander Erban, Leonardo Perez de Souza, Dorothee Childs, Izabela Wojciechowska, Urszula Luzarowska, Michał Górka, Ewelina M. Sokołowska, Monika Kosmacz, Juan C. Moreno, Aleksandra Brzezińska, Bhavana Vegesna, Joachim Kopka, Alisdair R. Fernie, Lothar Willmitzer, Jennifer C. Ewald, Aleksandra Skirycz
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Marcin Luzarowski et al. use a new method PROMIS for systematic analysis of protein small molecule interactions in yeast. Their work provides an experimentally-derived catalogue of protein–metabolite complexes in S. cerevisiae and reveals that the
Externí odkaz:
https://doaj.org/article/45b3e29eed33443991958a1e995a67de
Autor:
Erika Kelmer Sacramento, Joanna M Kirkpatrick, Mariateresa Mazzetto, Mario Baumgart, Aleksandar Bartolome, Simone Di Sanzo, Cinzia Caterino, Michele Sanguanini, Nikoletta Papaevgeniou, Maria Lefaki, Dorothee Childs, Sara Bagnoli, Eva Terzibasi Tozzini, Domenico Di Fraia, Natalie Romanov, Peter H Sudmant, Wolfgang Huber, Niki Chondrogianni, Michele Vendruscolo, Alessandro Cellerino, Alessandro Ori
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 6, Pp n/a-n/a (2020)
Abstract A progressive loss of protein homeostasis is characteristic of aging and a driver of neurodegeneration. To investigate this process quantitatively, we characterized proteome dynamics during brain aging in the short‐lived vertebrate Nothobr
Externí odkaz:
https://doaj.org/article/d0fdedc91a124678a4c4681ccc1e444c
Autor:
Nicolás E. Figueroa, Peter Franz, Marcin Luzarowski, Federico Martinez‐Seidel, Juan C. Moreno, Dorothee Childs, Aleksandra Ziemblicka, Arun Sampathkumar, Tonni Grube Andersen, Georgios Tsiavaliaris, Monika Chodasiewicz, Aleksandra Skirycz
Publikováno v:
The Plant Journal.
Autor:
Nils Kurzawa, Marcus Bantscheff, Mikhail M. Savitski, Eugenia Stonehouse, Maria Faelth-Savitski, Holger Franken, Bianca Heller, Christina Rau, Jessica Perrin, Anna Rutkowska, H. Christian Eberl, Johanna Vappiani, Daniel C. Sévin, Isabelle Becher, Katrin Strohmer, Jana Krause, Thilo Werner, Douglas W. Thomson, Wolfgang Huber, Daniel Poeckel, Giovanna Bergamini, Mathias Kalxdorf, Dorothee Childs
Publikováno v:
Nature Biotechnology. 38:303-308
Monitoring drug-target interactions with methods such as the cellular thermal-shift assay (CETSA) is well established for simple cell systems but remains challenging in vivo. Here we introduce tissue thermal proteome profiling (tissue-TPP), which mea
Autor:
Monika Chodasiewicz, Nicolás E. Figueroa, Peter Franz, Marcin Luzarowski, Juan C. Moreno, Dorothee Childs, Aleksandra Masiuk, Manny Saluja, Arun Sampathkumar, Georgios Tsiavaliaris, Aleksandra Skirycz
The role of cyclic adenosine monophosphate (3’,5’-cAMP) in plants is not well understood, and here, we report a novel role of 3’,5’-cAMP in regulating the actin cytoskeleton. The 3’,5’-cAMP treatment affects the thermal stability of 51 pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19470f46fbfb226e23d5467a46049425
https://doi.org/10.1101/2022.01.31.478439
https://doi.org/10.1101/2022.01.31.478439
Autor:
Dennis Schlossarek, Dorothee Childs, Mateusz Wagner, Alexander Erban, Joachim Kopka, Juan Moreno, Urszula Luzarowska, Izabela Wojciechowska, Leonardo Perez de Souza, Rubén Vicente, Monika Kosmacz, Michal Gorka, Aleksandra Skirycz, Bhavana Vegesna, Aleksandra Brzezińska, Andrei Kiselev, Ewelina M. Sokolowska, Jennifer C. Ewald, Marcin Luzarowski, Lothar Willmitzer, Alisdair R. Fernie
Publikováno v:
Communications Biology
Communications Biology, Nature Publishing Group, 2021, 4 (1), 15 p. ⟨10.1038/s42003-021-01684-3⟩
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Communications Biology, Nature Publishing Group, 2021, 4 (1), 15 p. ⟨10.1038/s42003-021-01684-3⟩
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Protein–metabolite interactions are of crucial importance for all cellular processes but remain understudied. Here, we applied a biochemical approach named PROMIS, to address the complexity of the protein–small molecule interactome in the model y
Autor:
Ana-Maria Gätjens-Sanchez, Paulina Richter-Pechanska, Maurice Reimann, Liam Childs, Ruth Flümann, Anna Dolnik, Timon Pablo Hick, Lars Bullinger, Dorothy N. Y. Fan, Dorothee Childs, Kolja Schleich, Clemens A. Schmitt, Jens Schrezenmeier, Sven Maßwig, Andreas Rosenwald, Sophy Denker, Hans Christian Reinhardt, Philipp Lohneis, Antonia Busse, Gero Knittel, Xiurong Cai
Publikováno v:
Blood. 137(20)
Aberrant B-cell receptor/NF-κB signaling is a hallmark feature of B-cell non-Hodgkin lymphomas, especially in diffuse large B-cell lymphoma (DLBCL). Recurrent mutations in this cascade, for example, in CD79B, CARD11, or NFKBIZ, and also in the Toll-
Autor:
Dorothee Childs, Simon Anders, Wolfgang Huber, Karsten Bach, Holger Franken, Mikhail M. Savitski, Nils Kurzawa, Marcus Bantscheff
Publikováno v:
Molecular & Cellular Proteomics : MCP
A method for nonparametric analysis of response curves from thermal proteome profiling (TPP) experiments is proposed. The approach achieves high proteome coverage and sensitivity while controlling the false discovery-rate. Free open source software f
Autor:
Joanna Kirkpatrick, Alessandro Ori, Cinzia Caterino, Eva Terzibasi Tozzini, Erika Kelmer Sacramento, Michele Vendruscolo, Wolfgang Huber, Mariateresa Mazzetto, Mario Baumgart, Niki Chondrogianni, Peter H. Sudmant, Natalie Romanov, Sara Bagnoli, Alessandro Cellerino, Maria Lefaki, Dorothee Childs, Simone Di Sanzo, Aleksandar Bartolome, Nikoletta Papaevgeniou, Michele Sanguanini, Domenico Di Fraia
Publikováno v:
Molecular Systems Biology
Molecular Systems Biology, Vol 16, Iss 6, Pp n/a-n/a (2020)
Molecular Systems Biology, Vol 16, Iss 6, Pp n/a-n/a (2020)
A progressive loss of protein homeostasis is characteristic of aging and a driver of neurodegeneration. To investigate this process quantitatively, we characterized proteome dynamics during brain aging in the short‐lived vertebrate Nothobranchius f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::403fe73490e8a5e536ead8e90b7e9e90
https://doi.org/10.1101/577478
https://doi.org/10.1101/577478
Autor:
Johanna Vappiani, Mikhail M. Savitski, Maria Faelth-Savitski, H. Christian Eberl, Dorothee Childs, Bianca Heller, Wolfgang Huber, Holger Franken, Jessica Perrin, Nils Kurzawa, Christina Rau, Daniel C. Sévin, Jana Krause, Marcus Bantscheff, Eugenia Stonehouse, Douglas W. Thomson, Daniel Poeckel, Anna Rutkowska, Giovanna Bergamini, Katrin Strohmer, Mathias Kalxdorf, Thilo Werner
Studying biological processes at a molecular level and monitoring drug-target interactions is established for simple cell systems but challenging in vivo. We introduce and apply a methodology for proteome-wide thermal stability measurements to charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af7eb2478837b12c2632cb21c39351a
https://doi.org/10.1101/500306
https://doi.org/10.1101/500306