Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Dorothee Abramowski"'
Autor:
Dieter Lütjohann, Andreas Brzezinka, Esther Barth, Dorothee Abramowski, Matthias Staufenbiel, Klaus von Bergmann, Konrad Beyreuther, Gerd Multhaup, Thomas A. Bayer
Publikováno v:
Journal of Lipid Research, Vol 43, Iss 7, Pp 1078-1085 (2002)
Cholesterol is implicated to play a role in Alzheimer disease pathology. Therefore, the concentrations of cholesterol, its precursors, and its degradation products in brain homogenates of aging wild-type and β-amyloid precursor protein transgenic mi
Externí odkaz:
https://doaj.org/article/a4e0bffcac134473b2790d13b6d0fde3
Autor:
Douglas Young, Franziska Mayer, Nella Vidotto, Tatjana Schweizer, Ramon Berth, Dorothee Abramowski, Derya R Shimshek, P Herman van der Putten, Peter Schmid
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75108 (2013)
Huntington's disease (HD) is an autosomal dominant, progressive and fatal neurological disorder caused by an expansion of CAG repeats in exon-1 of the huntingtin gene. The encoded poly-glutamine stretch renders mutant huntingtin prone to aggregation.
Externí odkaz:
https://doaj.org/article/d6d72d0f0df640b8ad38ab7cf5733527
Autor:
David Marcellin, Dorothee Abramowski, Douglas Young, Jens Richter, Andreas Weiss, Audrey Marcel, Julia Maassen, Muriel Kauffmann, Miriam Bibel, Derya R Shimshek, Richard L M Faull, Gillian P Bates, Rainer R Kuhn, P Herman Van der Putten, Peter Schmid, Gregor P Lotz
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44457 (2012)
Cleavage of the full-length mutant huntingtin (mhtt) protein into smaller, soluble aggregation-prone mhtt fragments appears to be a key process in the neuropathophysiology of Huntington's Disease (HD). Recent quantification studies using TR-FRET-base
Externí odkaz:
https://doaj.org/article/301db3dcf0a2450bab3b38981ddf66c9
Autor:
Michael R. Schlabach, Frank Stegmeier, Tobias Schmelzle, William R. Sellers, Francesco Hofmann, Nicholas Keen, E. Robert McDonald, Audrey Kauffmann, Odile Weber, Rosalie de Beaumont, Daniel Rakiec, Sarah Y. Neshat, Matthew D. Shirley, Jessica Wan, Dorothee Abramowski, Antoine DeWeck, Gregory McAllister, Kristine Yu, David A. Ruddy, Javad Golji, Michael D. Jones, Joshua M. Korn, Eric Billy, Li Li, Pamela J. Cassiani, Diana M. Munoz
Correlation analysis matrix displaying features that correlate most strongly with sgRNA's having off target effects.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7173657ab8c9cebbe2e61d7645ea2b63
https://doi.org/10.1158/2159-8290.22531563.v1
https://doi.org/10.1158/2159-8290.22531563.v1
Autor:
Zainab Jagani, Deborah Castelletti, Hyo-eun C. Bhang, David A. Ruddy, Audrey Kauffmann, Julien P.N. Papillon, Troy Smith, Rukundo Ntaganda, Simon Mathieu, Christopher D. Adair, Katsumasa Nakajima, Henrik Möbitz, Anthony Vattay, Anka Bric, Matthew D. Shirley, Yun Feng, Geoffrey Bushold, Kay X. Xiang, Ali Farsidjani, Julie T. Chen, Dorothee Abramowski, Aurore Desplat, Grainne Kerr, Kathleen Sprouffske, Ailing Li, GiNell Elliott, Florencia Rago
Additional method details for ATAC-Seq Data Analysis and ChIP-qPCR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667bbae7f1dda626aef222d2078505f7
https://doi.org/10.1158/1535-7163.22519459
https://doi.org/10.1158/1535-7163.22519459
Autor:
Michael R. Schlabach, Frank Stegmeier, Tobias Schmelzle, William R. Sellers, Francesco Hofmann, Nicholas Keen, E. Robert McDonald, Audrey Kauffmann, Odile Weber, Rosalie de Beaumont, Daniel Rakiec, Sarah Y. Neshat, Matthew D. Shirley, Jessica Wan, Dorothee Abramowski, Antoine DeWeck, Gregory McAllister, Kristine Yu, David A. Ruddy, Javad Golji, Michael D. Jones, Joshua M. Korn, Eric Billy, Li Li, Pamela J. Cassiani, Diana M. Munoz
Supplementary Figure Legends, Table Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb53e60107d91f1fd9557bb4a74a377e
https://doi.org/10.1158/2159-8290.22531569
https://doi.org/10.1158/2159-8290.22531569
Autor:
Zainab Jagani, Deborah Castelletti, Hyo-eun C. Bhang, David A. Ruddy, Audrey Kauffmann, Julien P.N. Papillon, Troy Smith, Rukundo Ntaganda, Simon Mathieu, Christopher D. Adair, Katsumasa Nakajima, Henrik Möbitz, Anthony Vattay, Anka Bric, Matthew D. Shirley, Yun Feng, Geoffrey Bushold, Kay X. Xiang, Ali Farsidjani, Julie T. Chen, Dorothee Abramowski, Aurore Desplat, Grainne Kerr, Kathleen Sprouffske, Ailing Li, GiNell Elliott, Florencia Rago
Supplementary Table S1 lists biochemical and cellular activity of BRG1/BRM inhibitors. Supplementary Table S2 lists BRM011 and BRM014 activity across cell line panel. Supplementary Table S3 lists cell lines generated for this study. Supplementary Tab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65ff6df114c3445da1491dc2bf68ac80
https://doi.org/10.1158/1535-7163.22519456
https://doi.org/10.1158/1535-7163.22519456
Autor:
Michael R. Schlabach, Frank Stegmeier, Tobias Schmelzle, William R. Sellers, Francesco Hofmann, Nicholas Keen, E. Robert McDonald, Audrey Kauffmann, Odile Weber, Rosalie de Beaumont, Daniel Rakiec, Sarah Y. Neshat, Matthew D. Shirley, Jessica Wan, Dorothee Abramowski, Antoine DeWeck, Gregory McAllister, Kristine Yu, David A. Ruddy, Javad Golji, Michael D. Jones, Joshua M. Korn, Eric Billy, Li Li, Pamela J. Cassiani, Diana M. Munoz
Supplementary Figure S1. Comparison of drop out phenotypes in MKN45, RKO, HT1080 highlighting selected pan-lethal genes. Supplementary Figure S2. The genes that scored as lethal by both RNAi and CRISPR were strongly enriched for known essential genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b398466e1fca85bee6e1c3e61c9c3ad
https://doi.org/10.1158/2159-8290.22531566
https://doi.org/10.1158/2159-8290.22531566
Autor:
Zainab Jagani, Deborah Castelletti, Hyo-eun C. Bhang, David A. Ruddy, Audrey Kauffmann, Julien P.N. Papillon, Troy Smith, Rukundo Ntaganda, Simon Mathieu, Christopher D. Adair, Katsumasa Nakajima, Henrik Möbitz, Anthony Vattay, Anka Bric, Matthew D. Shirley, Yun Feng, Geoffrey Bushold, Kay X. Xiang, Ali Farsidjani, Julie T. Chen, Dorothee Abramowski, Aurore Desplat, Grainne Kerr, Kathleen Sprouffske, Ailing Li, GiNell Elliott, Florencia Rago
Supplementary Figure S1 shows additional shRNA knockdown data in uveal melanoma cell lines. Supplementary Figure S2 shows additional dual BRG1/BRM knockdown data and BRG1 rescue data. Supplementary Figure S3 shows basal SWI/SNF subunit expression, ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54896da058f0b4949ae1ea1abc687f7e
https://doi.org/10.1158/1535-7163.22519462.v1
https://doi.org/10.1158/1535-7163.22519462.v1
Autor:
Matthew D. Shirley, Julie T. Chen, Ailing Li, Anthony Vattay, David A. Ruddy, Anka Bric, Kay X. Xiang, Simon Mathieu, Troy Smith, Julien Papillon, Deborah Castelletti, Rukundo Ntaganda, Kathleen Sprouffske, Hyo-eun C. Bhang, Yun Feng, Dorothee Abramowski, Ali Farsidjani, Audrey Kauffmann, Grainne Kerr, Aurore Desplat, Geoffrey Bushold, Katsumasa Nakajima, Henrik Möbitz, GiNell Elliott, Christopher D. Adair, Zainab Jagani, Florencia Rago
Publikováno v:
Molecular Cancer Therapeutics. 19:2186-2195
Uveal melanoma is a rare and aggressive cancer that originates in the eye. Currently, there are no approved targeted therapies and very few effective treatments for this cancer. Although activating mutations in the G protein alpha subunits, GNAQ and