Chronic Inflammation Increases the Sensitivity of Mouse Treg for TNFR2 Costimulation

Autor: Tobias Schmid, Lena Falter, Sabine Weber, Nils Müller, Konstantin Molitor, David Zeller, Dorothea Weber-Steffens, Thomas Hehlgans, Harald Wajant, Sven Mostböck, Daniela N. Männel

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

TNF receptor type 2 (TNFR2) has gained attention as a costimulatory receptor for T cells and as critical factor for the development of regulatory T cells (Treg) and myeloid suppressor cells. Using the TNFR2-specific agonist TNCscTNF80, direct effects

Externí odkaz: https://doaj.org/article/2350445363bd4deea143a14df744bc25

Stimulation of TNF receptor type 2 expands regulatory T cells and ameliorates established collagen-induced arthritis in mice

Autor: Rainer H. Straub, Vanessa Lamontain, Zsuzsa Jenei-Lanzl, Harald Wajant, Daniela N. Männel, David Zeller, Tobias Schmid, Dorothea Weber-Steffens

Publikováno v: Cellular & Molecular Immunology. 16:65-74

Tumor necrosis factor (TNF) and its receptors TNF receptor type 1 (TNFR1) and type 2 (TNFR2) have a central role in chronic inflammatory diseases. While TNFR1 mainly confers inflammation, activation of TNFR2 elicits not only pro-inflammatory but also

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96df06c0ee1847f30166ec5587f18e14
https://doi.org/10.1038/cmi.2017.138

Functional analysis of mouse ficolin-B and detection in neutrophils

Autor: Jens C. Jensenius, Daniela N. Männel, Katja Hunold, Valeria L. Runza, Dorothea Weber-Steffens

Publikováno v: Hunold, K, Weber-Steffens, D, Runza, V L, Jensenius, J C & Männel, D N 2012, ' Functional analysis of mouse ficolin-B and detection in neutrophils ', Immunobiology, vol. 217, no. 10, pp. 982-5 . https://doi.org/10.1016/j.imbio.2012.01.013

Ficolins and mannan-binding lectin recognize pathogen-associated molecular patterns and initiate the lectin pathway of complement activation via the associated serine proteases. In contrast to human ficolins and mouse ficolin-A, mouse ficolin-B has b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fcb67944811768a03174074a06f315a
https://doi.org/10.1016/j.imbio.2012.01.013

Immature mouse granulocytic myeloid cells are characterized by production of ficolin-B

Autor: Dominic Schmidt, Johanna Kürschner, Sonia Giraldez Martinez, Katja Hunold, Daniela N. Männel, Analía Silvina Trevani, Preetham Elumalai, Dorothea Weber-Steffens, Valeria L. Runza

Ficolins activate the lectin pathway of the complement system upon binding to carbohydrate patterns on pathogens. To characterize the producer cells of ficolin-B the expression of mouse ficolin-B, the orthologue of human M-ficolin, was studied in mac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::264604dc6ee0ab893d2526d2e83febf8
http://www.sciencedirect.com/science/article/pii/S0161589013004343