Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Dorothea Tzvetkova-Robev"'
Publikováno v:
Genes & Development. 29:785-790
The amyloid precursor protein (APP) has garnered considerable attention due to its genetic links to Alzheimer's disease. Death receptor 6 (DR6) was recently shown to bind APP via the protein extracellular regions, stimulate axonal pruning, and inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1fc32d3f0ddf6502215dddf7a9f3608
https://doi.org/10.1101/gad.257675.114
https://doi.org/10.1101/gad.257675.114
Autor:
Dorothea Tzvetkova-Robev, Zhuhao Wu, Juha P. Himanen, Nicolas Renier, Alexander Antipenko, Vincenzo Nardi-Dei, Dimitar B. Nikolov, Yan Xu, Kanagalaghatta R. Rajashankar, Marc Tessier-Lavigne, Kai Xu, Maria Minchenko
Publikováno v:
Science. 344:1275-1279
Dissecting how signaling directs axon growth During development of the nervous system, nerve cells send out projections called axons that must be guided to their proper targets. Netrins are secreted proteins that bind to receptors to either attract o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2433d16f0596712e6f00e82cc0d4bc9
https://doi.org/10.1126/science.1255149
https://doi.org/10.1126/science.1255149
Autor:
Annamarie C. Dalton, Tom C. M. Seegar, Yehuda Goldgur, Dimitar B. Nikolov, Xuehong Yu, Kanagalaghatta R. Rajashankar, Dorothea Tzvetkova-Robev, William A. Barton
Publikováno v:
Proceedings of the National Academy of Sciences. 110:7205-7210
Angiogenesis is a complex cellular process involving multiple regulatory growth factors and growth factor receptors. Among them, the ligands for the endothelial-specific tunica intima endothelial receptor tyrosine kinase 2 (Tie2) receptor kinase, ang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef643e9bce0e686f2e4db784b89f322d
https://doi.org/10.1073/pnas.1216890110
https://doi.org/10.1073/pnas.1216890110
Autor:
Dimitar B. Nikolov, Yee-Peng Chan, Yehuda Goldgur, Kai Xu, Juha P. Himanen, Yan Xu, Dorothea Tzvetkova-Robev
Eph receptor tyrosine kinases and their ephrin ligands mediate cell signaling during normal and oncogenic development. Eph signaling is initiated in a multistep process leading to the assembly of higher-order Eph/ephrin clusters that set off bidirect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f888ce2c17db08bc6476ed024fe2f2
https://europepmc.org/articles/PMC3767517/
https://europepmc.org/articles/PMC3767517/
Autor:
Becca Eller, Dorothea Tzvetkova-Robev, Tom C. M. Seegar, William A. Barton, Momchil V. Kolev, Scott C. Henderson, Dimitar B. Nikolov
Publikováno v:
Molecular cell. 37(5)
The endothelial specific receptor tyrosine kinase Tie2, and the orphan receptor tyrosine kinase, Tie1, are essential for endothelial cell proliferation, migration, and survival during angiogenesis. Despite their considerable similarity, experiments w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b7320d71f14c0bd95281cbeadc6b523
https://pubmed.ncbi.nlm.nih.gov/20227369
https://pubmed.ncbi.nlm.nih.gov/20227369
Autor:
Dimitar B. Nikolov, Paul Tempst, Hediye Erdjument-Bromage, Dorothea Tzvetkova-Robev, William A. Barton
Publikováno v:
Protein science : a publication of the Protein Society. 15(8)
The advent of the multiwavelength anomalous diffraction phasing method has significantly accelerated crystal structure determination and has become the norm in protein crystallography. This method allows researchers to take advantage of the anomalous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70f5185780d994034781f97dff518061
https://pubmed.ncbi.nlm.nih.gov/16823037
https://pubmed.ncbi.nlm.nih.gov/16823037
Autor:
Juha P. Himanen, Momchil V. Kolev, Edward P Miranda, Dorothea Tzvetkova-Robev, Kanagalaghatta R. Rajashankar, William A. Barton, Dimitar B. Nikolov
Publikováno v:
Nature structuralmolecular biology. 13(6)
The Tie receptor tyrosine kinases and their angiopoietin (Ang) ligands play central roles in developmental and tumor-induced angiogenesis. Here we present the crystal structures of the Tie2 ligand-binding region alone and in complex with Ang2. In con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb4eb5fd9c40db6f5ece8e1538edc75c
https://pubmed.ncbi.nlm.nih.gov/16732286
https://pubmed.ncbi.nlm.nih.gov/16732286