Výsledky vyhledávání - "Dorothea Scandella"

Two classes of germline genes both derived from the V(H)1 family direct the formation of human antibodies that recognize distinct antigenic sites in the C2 domain of factor VIII

Autor: Wendy S. Bril, Thomas L. Ortel, Dorothea Scandella, Deborah A. Lewis, Ellen A. M. Turenhout, Edward N. van den Brink, Jan Voorberg, Niels Bovenschen, Marjolein Peters, Marleen G. Zuurveld, Pete Lollar, Koen Mertens, Thynn Thynn Yee

Publikováno v: Blood, 99(8), 2828-2834. American Society of Hematology

Most plasmas from patients with inhibitors contain antibodies that are reactive with the C2 domain of factor VIII. Previously, we have shown that the variable heavy chain (V(H)) regions of antibodies to the C2 domain are encoded by the closely relate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1095a561f15915542ee89b581a1307d
https://doi.org/10.1182/blood.v99.8.2828

Zobrazit plný text záznamu

Antibodies to the FVIII light chain that neutralize FVIII procoagulant activity are present in plasma of nonresponder patients with severe hemophilia A and in normal polyclonal human IgG

Autor: Roseline d'Oiron, Alexandre Moreau, Sébastien Lacroix-Desmazes, Dorothea Scandella, Evgueni L. Saenko, Yvette Sultan, N. Stieltjes, Michel D. Kazatchkine, Srini V. Kaveri

Publikováno v: Europe PubMed Central

We have analyzed the properties of anti-factor VIII (FVIII) immunoglobulin (Ig) G recovered by affinity chromatography on FVIII-Sepharose from the IgG fraction of the plasma of healthy individuals and nonresponder patients with hemophilia A. Affinity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c9f366f58c83bbbf525dbe7a8ba77bb
https://doi.org/10.1182/blood.v95.11.3435

Zobrazit plný text záznamu

Reduction of the antigenicity of factor VIII toward complex inhibitory antibody plasmas using multiply-substituted hybrid human/porcine factor VIII molecules

Autor: Rachel T. Barrow, David Gailani, Pete Lollar, John F. Healey, Dorothea Scandella

Publikováno v: Blood. 95:564-568

Factor VIII (fVIII) circulates as a heavy chain/light chain (A1-A2-B/ap-A3-C1-C2) heterodimer. The 41-residue light chain activation peptide, ap, is cleaved from fVIII during proteolytic activation by thrombin or factor Xa. We constructed 7 active re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f1a076bca2f5ed2246e0cd27ad5031d9
https://doi.org/10.1182/blood.v95.2.564

Zobrazit plný text záznamu

Human Inhibitor Antibodies Specific for the Factor VIII A2 Domain Disrupt the Interaction between the Subunit and Factor IXa

Autor: Dorothea Scandella, Philip J. Fay

Publikováno v: Journal of Biological Chemistry. 274:29826-29830

Factor VIIIa, a heterotrimer of the A1, A2, and A3-C1-C2 subunits, increases the catalytic efficiency for factor IXa-catalyzed activation of factor X. A significant fraction of naturally occurring, anti-factor VIII inhibitor antibodies reacts with th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f5a05a303bedfb7b003d25ca56132b
https://doi.org/10.1074/jbc.274.42.29826

Zobrazit plný text záznamu

Identification of a factor VIII peptide, residues 2315-2330, which neutralizes human factor VIII C2 inhibitor alloantibodies: requirement of Cys2326and Glu2327for maximum effect

Autor: Midori Shima, Hiroshi Suzuki, Ichiro Tanaka, Shogo Morichika, Hiroaki Nakai, Keiji Nogami, Masaru Shibata, John C. Giddings, Dorothea Scandella, Evgueni L. Saenko, Akira Yoshioka

Publikováno v: British Journal of Haematology. 107:196-203

Factor VIII (FVIII) inhibitor alloantibodies react with combinations of the A2, C2 and A3-C1 domains of the FVIII molecule. Some inhibitors block binding of FVIII to both von Willebrand factor (VWF) and phospholipid, and recognize a C2 domain epitope

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ca237bf0ee45e581b7486f530c439c1a
https://doi.org/10.1046/j.1365-2141.1999.01673.x

Zobrazit plný text záznamu

Antifactor VIII Antibody Inhibiting Allogeneic but not Autologous Factor VIII in Patients With Mild Hemophilia A

Autor: Marc Hoylaerts, Marc Jacquemin, Dorothea Scandella, Kathelijne Peerlinck, Jean Guy Gilles, Jef Arnout, Karen M. Johnson, Kathleen Freson, Jos Vermylen, Jean-Marie Saint-Remy, Renaud Lavend'homme

Publikováno v: Blood. 93:2267-2273

Two unrelated patients with the same Arg2150His mutation in the factor VIII (FVIII) C1 domain, a residual FVIII activity of 0.09 IU/mL, and inhibitor titres of 300 and 6 Bethesda Units, respectively, were studied. Further analysis of patient LE, with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0859381a0d6c416027d163d0aa9d6a1d
https://doi.org/10.1182/blood.v93.7.2267

Zobrazit plný text záznamu

Antifactor VIII Antibody Inhibiting Allogeneic but not Autologous Factor VIII in Patients With Mild Hemophilia A

Autor: Kathelijne Peerlinck, Marc G. Jacquemin, Jef Arnout, Marc F. Hoylaerts, Jean Guy G. Gilles, Renaud Lavend’homme, Karen M. Johnson, Kathleen Freson, Dorothea Scandella, Jean-Marie R. Saint-Remy, Jos Vermylen

Publikováno v: Blood. 93:2267-2273

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc647fbbbfd4696622a4a78a79560df9
https://doi.org/10.1182/blood.v93.7.2267.407k21_2267_2273

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání