Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Dorothea K, Torous"'
Autor:
Dorothea K. Torous, Svetlana Avlasevich, Jeffrey C. Bemis, Thad Howard, Russell E. Ware, Chunkit Fung, Yuhchyau Chen, Deepak Sahsrabudhe, James T. MacGregor, Stephen D. Dertinger
Publikováno v:
Environmental and Molecular Mutagenesis. 64:167-175
Autor:
Stephanie L. Smith‐Roe, Stavros Garantziotis, Rebecca L. Church, Jeffrey C. Bemis, Dorothea K. Torous, Kim G. Shepard, Cheryl A. Hobbs, Suramya Waidyanatha, Esra Mutlu, Keith R. Shockley, Grace E. Kissling, Sandra J. McBride, Guanhua Xie, Tim Cristy, Jessica Pierfelice, Kristine L. Witt
Publikováno v:
Environ Mol Mutagen
Black cohosh (BC; Actaea racemosa L.), a top-selling botanical dietary supplement, is marketed to women primarily to ameliorate a variety of gynecological symptoms. Due to widespread usage, limited safety information, and sporadic reports of hepatoto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8568690d0ac87ececd0accb59d33cb
https://europepmc.org/articles/PMC10018809/
https://europepmc.org/articles/PMC10018809/
Autor:
Dorothea K. Torous, Lawrence J. Saubermann, Yuhchyau Chen, Svetlana L. Avlasevich, David P. Lovell, Stephen D. Dertinger, Vernon E. Walker, James T. MacGregor, Mona Khattab, Jeffrey C. Bemis, Ayesha Baig
Publikováno v:
Environ Mol Mutagen
We previously described flow cytometry-based methods for scoring the incidence of micronucleated reticulocytes (MN-RET) and PIG-A mutant phenotype reticulocytes (MUT RET) in rodent and human blood samples. The current report describes important metho
Autor:
Priyanka Singh, Amanda Drake, Stephen D. Dertinger, Svetlana L. Avlasevich, Jeffrey C. Bemis, Dorothea K. Torous, Sumee Khanal, Christopher Kirby, James T. MacGregor
Publikováno v:
Environ Mol Mutagen
Regulatory guidance documents stress the value of assessing the most appropriate endpoints in multiple tissues when evaluating the in vivo genotoxic potential of chemicals. However, conducting several independent studies to evaluate multiple endpoint
Autor:
Ishwar N. Kohale, Joshua J. Corrigan, Ilana S. Nazari, Leona D. Samson, Forest M. White, Sebastian E. Carrasco, Robert G. Croy, Dushan N. Wadduwage, Amanda L. Armijo, Jennifer E. Kay, Bevin P. Engelward, Stephen D. Dertinger, John M. Essigmann, Svetlana L. Avlasevich, Dorothea K. Torous
Publikováno v:
Cell Rep
Elsevier
Elsevier
SummaryN-nitrosodimethylamine (NDMA) is a DNA methylating agent that has been discovered to contaminate water, food and drugs. The alkyladenine glycosylase (AAG) removes methylated bases to initiate the base excision repair (BER) pathway. To understa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e142bd257cb89cb964406cf85acc6f9e
https://doi.org/10.1101/2021.01.12.426356
https://doi.org/10.1101/2021.01.12.426356
Autor:
David P. Lovell, Lawrence J. Saubermann, Ayesha Baig, Jeffrey C. Bemis, James T. MacGregor, Svetlana L. Avlasevich, Dorothea K. Torous, Stephen D. Dertinger
Publikováno v:
Environ Mol Mutagen
The etiology of distal site cancers in inflammatory bowel disease (IBD) is not well understood and requires further study. We investigated whether pediatric IBD patients' blood cells exhibit elevated levels of genomic damage by measuring the frequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0702e357056ecca10fd768d6a599eb5a
https://europepmc.org/articles/PMC8597720/
https://europepmc.org/articles/PMC8597720/
Autor:
Ayesha Baig, Christopher Kirby, Shuchang Tian, Jeffrey C. Bemis, Priyanka Singh, Stephen D. Dertinger, Lawrence J. Saubermann, Svetlana L. Avlasevich, Dorothea K. Torous
Publikováno v:
Mutagenesis
Inflammatory bowel disease (IBD) is an important risk factor for gastrointestinal cancers. Inflammation and other carcinogenesis-related effects at distal, tissue-specific sites require further study. In order to better understand if systemic genotox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95a621ac5d1922b4ecfdec19de24459c
https://europepmc.org/articles/PMC7373322/
https://europepmc.org/articles/PMC7373322/
Autor:
Svetlana L. Avlasevich, Dorothea K. Torous, Hans-Joerg Martus, Stephen D. Dertinger, Oliver O'Connell, Jeffrey C. Bemis, Tamsanqa Tafara Hove, Azeddine Elhajouji
Publikováno v:
Environmental and molecular mutagenesisREFERENCES. 61(5)
The in vivo Pig-a assay is being used in safety studies to evaluate the potential of chemicals to induce somatic cell gene mutations. Ongoing work is aimed at developing an Organization for Economic Cooperation and Development (OECD) test guideline t
Autor:
Svetlana L. Avlasevich, Demetria Thomas, Cameron C. Tebbe, Brett Schneider, Mary Richardson, Matthew Barragato, B. Bhaskar Gollapudi, Dorothea K. Torous, Daniel J. Roberts, John Prattico, Jessica Noteboom, Stephen D. Dertinger, Jeffrey C. Bemis, Javed A. Bhalli
Publikováno v:
Environmental and Molecular Mutagenesis. 60:47-55
The rodent blood Pig-a assay has been undergoing international validation for use as an in vivo hematopoietic cell gene mutation assay, and given the promising results an Organization for Economic Co-operation and Development (OECD) Test Guideline is
Autor:
Sumee Khanal, Jeffrey C. Bemis, Stephen D. Dertinger, Priyanka Singh, Svetlana L. Avlasevich, Dorothea K. Torous
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 828:30-35
Regulatory guidance documents stress the value of assessing multiple tissues and the most appropriate endpoints when evaluating chemicals for in vivo genotoxic potential. However, conducting several independent studies to consider multiple endpoints