Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Dorothea Haasen"'
Autor:
Giulia Di Marco, Francesca Vallese, Benjamin Jourde, Christian Bergsdorf, Mattia Sturlese, Agnese De Mario, Valerie Techer-Etienne, Dorothea Haasen, Berndt Oberhauser, Simone Schleeger, Giulia Minetti, Stefano Moro, Rosario Rizzuto, Diego De Stefani, Mara Fornaro, Cristina Mammucari
Publikováno v:
Cell Reports, Vol 30, Iss 7, Pp 2321-2331.e6 (2020)
Summary: Mitochondrial Ca2+ uptake depends on the mitochondrial calcium uniporter (MCU) complex, a highly selective channel of the inner mitochondrial membrane (IMM). Here, we screen a library of 44,000 non-proprietary compounds for their ability to
Externí odkaz:
https://doaj.org/article/d25f73fedd1e4a3f98bcf5f6b17f78fb
Autor:
Francesco Hofmann, William R. Sellers, Clive McCarthy, Markus Wartmann, Peter Drueckes, Dorothea Haasen, Jutta Blank, Michael D. Jones, John E. Monahan, David A. Ruddy, Emily Buck, Joseph Schoepfer, Sabrina Wagner, Brent A. Appleton, Pascal Furet, Elisa Degenkolbe, Ralph Tiedt
Supplementary Figures 1-2, Tables 1-4, Methods from A Drug Resistance Screen Using a Selective MET Inhibitor Reveals a Spectrum of Mutations That Partially Overlap with Activating Mutations Found in Cancer Patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3613711d07dd229641d5f5262ca31848
https://doi.org/10.1158/0008-5472.22388450.v1
https://doi.org/10.1158/0008-5472.22388450.v1
Autor:
Nicolas Soldermann, Ian Lewis, Alexander Baxter Smith, Klemens Hoegenauer, Frédéric Zecri, Dorothea Haasen, Anette Von Matt, Gregory Hollingworth, Christoph Burkhart, Christina Hebach, Rainer Wilcken, Romain M. Wolf
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5657-5662
In the recent years, PI3Kδ has emerged as a promising target for the treatment of B- and T-cell mediated inflammatory diseases. We present a cellular assay activity analysis for our previously reported 4,6-diaryl quinazoline PI3Kδ inhibitor series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2d9d71e823031bb6f22f69b819f64c
https://doi.org/10.1016/j.bmcl.2016.10.069
https://doi.org/10.1016/j.bmcl.2016.10.069
Autor:
Simone Schleeger, Mara Fornaro, Christian Bergsdorf, Benjamin Jourde, Valerie Techer-Etienne, Mattia Sturlese, Diego De Stefani, Rosario Rizzuto, Stefano Moro, Agnese De Mario, Cristina Mammucari, Francesca Vallese, Giulia Minetti, Berndt Oberhauser, Dorothea Haasen, Giulia Di Marco
Publikováno v:
Cell Reports
Cell Reports, Vol 30, Iss 7, Pp 2321-2331.e6 (2020)
Cell Reports, Vol 30, Iss 7, Pp 2321-2331.e6 (2020)
Summary Mitochondrial Ca2+ uptake depends on the mitochondrial calcium uniporter (MCU) complex, a highly selective channel of the inner mitochondrial membrane (IMM). Here, we screen a library of 44,000 non-proprietary compounds for their ability to m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e664e1713a2bfee1a2e8bf68ff2ce39
https://doi.org/10.1016/j.celrep.2020.01.081
https://doi.org/10.1016/j.celrep.2020.01.081
Autor:
Christophe Antczak, Chantale T. Guy, Ulrich Schopfer, Dorothea Haasen, Florian Fuchs, Paul Selzer
Publikováno v:
Assay and drug development technologies. 15(6)
Since 2011, phenotypic screening has been a trend in the pharmaceutical industry as well as in academia. This renaissance was triggered by analyses that suggested that phenotypic screening is a superior strategy to discover first-in-class drugs. Desp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d4586c94ef56922bcc05fbe1f503c18
https://pubmed.ncbi.nlm.nih.gov/28800248
https://pubmed.ncbi.nlm.nih.gov/28800248
Autor:
Jutta Blank, David A. Ruddy, Elisa Degenkolbe, Dorothea Haasen, Pascal Furet, Joseph Schoepfer, Ralph Tiedt, Brent A. Appleton, Sabrina Wagner, Francesco Hofmann, Michael D. Jones, John Monahan, Markus Wartmann, Clive Mccarthy, Peter Drueckes, William R. Sellers, Emily Buck
Publikováno v:
Cancer Research. 71:5255-5264
The emergence of drug resistance is a primary concern in any cancer treatment, including with targeted kinase inhibitors as exemplified by the appearance of Bcr-Abl point mutations in chronic myeloid leukemia (CML) patients treated with imatinib. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b39c282911cb88e005d88a37176fd51
https://doi.org/10.1158/0008-5472.can-10-4433
https://doi.org/10.1158/0008-5472.can-10-4433
Autor:
Barbara Kistler, Franz Oswald, Jörg Wiedenmann, Michael Wolff, Dorothea Haasen, G. Ulrich Nienhaus, Ralf Heilker, Simone Krede
Publikováno v:
Combinatorial Chemistry & High Throughput Screening. 13:3-15
Stimulation of CXC-type chemokine receptor 2 (CXCR2)-transfected cells by Gro-alpha or IL-8 induced (i) CXCR2 internalization, (ii) phosphorylation of ERK1/2 (pERK) and (iii) translocation of nuclear factor of activated T cells (NFAT) into the nucleu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf76db1ba4d5cff2f45817d008f30280
https://doi.org/10.2174/138620710790218249
https://doi.org/10.2174/138620710790218249
Publikováno v:
SLAS Discovery. 13:40-53
High-content screening, typically defined as automated fluorescence microscopy combined with image analysis, is now well established as a means to study test compound effects in cellular disease-modeling systems. In this work, the authors establish s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::448ff2fcdfe0e9f25411dfb966f54d52
https://doi.org/10.1177/1087057107312128
https://doi.org/10.1177/1087057107312128
Autor:
Pascal Furet, Jasmin Wirth, Dorothee Arz, Robin Alec Fairhurst, Giorgio Caravatti, Patricia Imbach-Weese, Marc Gerspacher, Daniel Guthy, Thomas Zoller, Christine Fritsch, Joerg Trappe, Dorothea Haasen
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(17)
Exploring the affinity-pocket binding moiety of a 2-aminothiazole (S)-proline-amide-urea series of selective PI3Kα inhibitors using a parallel-synthesis approach led to the identification of a novel 4',5-bisthiazole sub-series. The synthesis and opt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ce9b6ecf5bf0193f344d8a543efab1
https://pubmed.ncbi.nlm.nih.gov/26206504
https://pubmed.ncbi.nlm.nih.gov/26206504
Autor:
Susanne Merk, Ralf Heilker, Margareta Kroner, Jörg Wiedenmann, Michael Wolff, Dorothea Haasen, Udo Maier, Gerd Ulrich Nienhaus, Sandra Bordel, Martin J. Valler
Publikováno v:
Combinatorial Chemistry & High Throughput Screening. 9:339-350
High Content Screening (HCS), a combination of fluorescence microscopic imaging and automated image analysis, has become a frequently applied tool to study test compound effects in cellular disease-modelling systems. In this work, we established a me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89a3fbae1bf5ea35cc3a5df1f8238536
https://doi.org/10.2174/138620706777452447
https://doi.org/10.2174/138620706777452447