Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Dorothea Bankwitz"'
Autor:
Alina Matthaei, Sebastian Joecks, Annika Frauenstein, Janina Bruening, Dorothea Bankwitz, Martina Friesland, Gisa Gerold, Gabrielle Vieyres, Lars Kaderali, Felix Meissner, Thomas Pietschmann
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 2 (2024)
ABSTRACTAssembly of infectious hepatitis C virus (HCV) particles requires multiple cellular proteins including for instance apolipoprotein E (ApoE). To describe these protein-protein interactions, we performed an affinity purification mass spectromet
Externí odkaz:
https://doaj.org/article/376bdc7a189e4ffe9567f56ee0bc03d1
Autor:
Ieva Vasiliauskaite, Ania Owsianka, Patrick England, Abdul Ghafoor Khan, Sarah Cole, Dorothea Bankwitz, Steven K. H. Foung, Thomas Pietschmann, Joseph Marcotrigiano, Felix A. Rey, Arvind H. Patel, Thomas Krey
Publikováno v:
mBio, Vol 8, Iss 3 (2017)
ABSTRACT The hepatitis C virus (HCV) glycoprotein E2 is the major target of neutralizing antibodies and is therefore highly relevant for vaccine design. Its structure features a central immunoglobulin (Ig)-like β-sandwich that contributes to the bin
Externí odkaz:
https://doaj.org/article/a3bea6c8045c419198f363ad02f506f7
Autor:
Milena Lange, Melanie Fiedler, Dorothea Bankwitz, William Osburn, Sergei Viazov, Olena Brovko, Abdel-Rahman Zekri, Yury Khudyakov, Michael Nassal, Paul Pumpens, Thomas Pietschmann, Jörg Timm, Michael Roggendorf, Andreas Walker
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102235 (2014)
Hepatitis C virus (HCV) infection is still a serious global health burden. Despite improved therapeutic options, a preventative vaccine would be desirable especially in undeveloped countries. Traditionally, highly conserved epitopes are targets for a
Externí odkaz:
https://doaj.org/article/494b5dace8e14b3e8d30f38535f02c0d
Autor:
Nicolas Menzel, Wolfgang Fischl, Kathrin Hueging, Dorothea Bankwitz, Anne Frentzen, Sibylle Haid, Juliane Gentzsch, Lars Kaderali, Ralf Bartenschlager, Thomas Pietschmann
Publikováno v:
PLoS Pathogens, Vol 8, Iss 7, p e1002829 (2012)
Hepatitis C virus (HCV) has infected around 160 million individuals. Current therapies have limited efficacy and are fraught with side effects. To identify cellular HCV dependency factors, possible therapeutic targets, we manipulated signaling cascad
Externí odkaz:
https://doaj.org/article/60b449c1cbb44d7fa6971dd322b50980
Autor:
Patrick Chhatwal, Dorothea Bankwitz, Juliane Gentzsch, Anne Frentzen, Philipp Schult, Volker Lohmann, Thomas Pietschmann
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e36029 (2012)
BACKGROUND: Hepatitis C virus (HCV) patients with high serum levels of bile acids (BAs) respond poorly to IFN therapy. BAs have been shown to increase RNA-replication of genotype 1 but not genotype 2a replicons. Since BAs modulate lipid metabolism in
Externí odkaz:
https://doaj.org/article/9c820afe92ef43008799b39def240262
Autor:
Julia Bitzegeio, Dorothea Bankwitz, Kathrin Hueging, Sibylle Haid, Christiane Brohm, Mirjam B Zeisel, Eva Herrmann, Marcus Iken, Michael Ott, Thomas F Baumert, Thomas Pietschmann
Publikováno v:
PLoS Pathogens, Vol 6, p e1000978 (2010)
Hepatitis C virus (HCV) naturally infects only humans and chimpanzees. The determinants responsible for this narrow species tropism are not well defined. Virus cell entry involves human scavenger receptor class B type I (SR-BI), CD81, claudin-1 and o
Externí odkaz:
https://doaj.org/article/8993a7a785aa4054a305c13b2cffd220
Publikováno v:
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz. 65:183-191
ZusammenfassungMehr als 10 Jahre nach der Zulassung der ersten direkt wirkenden antiviralen Wirkstoffe zur Behandlung der Hepatitis C bleibt die Inzidenz der Hepatitis-C-Virus-(HCV-)Infektion ungebrochen hoch. In manchen Ländern stecken sich mehr Me
Autor:
Daniel Todt, Alice C. McHardy, Frank Klawonn, Dorothea Bankwitz, Mandy Doepke, Thomas Pietschmann, Markus Cornberg, Tanvi Khera, Patrick Behrendt, Akash Bahai, Florian Klein, Leona Dold, Thomas Krey, Corinne Ginkel, Luisa J Ströh, Maurice Labuhn
Publikováno v:
Gut
England
England
ObjectiveNeutralising antibodies are key effectors of infection-induced and vaccine-induced immunity. Quantification of antibodies’ breadth and potency is critical for understanding the mechanisms of protection and for prioritisation of vaccines. H
Publikováno v:
Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
The incidence of hepatitis C virus (HCV) infections remains high even more than 10 years after approval of the first direct-acting antivirals for treatment of hepatitis C. In some countries, more people are newly infected with the virus than patients
Autor:
Qinggong Yuan, Glenn Randall, Alexander Ploss, Dorothea Bankwitz, Chris Lauber, Tanvi Khera, Florian W. R. Vondran, Zoltán Ivics, Thomas Krey, Gabrielle Vieyres, Eleftherios Michailidis, Julie Sheldon, Eike Steinmann, Svenja M. Sake, Anggakusuma, Lieven Verhoye, Natascha Goedecke, Charles M. Rice, Birthe Tegtmeyer, Kathrin Welsch, Yudi Zhang, Gisa Gerold, Dagmar Wirth, Csaba Miskey, Michael Engelmann, Daniel Todt, Sebastian Joecks, Viet Loan Dao Thi, Yasmine Baktash, Philip Meuleman, Wolfgang Baumgärtner, Vanessa Herder, Thomas Pietschmann, C. Patrick McClure, Mohsan Saeed, Michael Ott, Romy Weller, Michael Seifert, Corinne Ginkel, Alexander W. Tarr, Richard J. C. Brown, Luisa J Ströh
Publikováno v:
Science Advances
eabd3233
Science advances, 6:eabd3233
SCIENCE ADVANCES
eabd3233
Science advances, 6:eabd3233
SCIENCE ADVANCES
Two transmembrane proteins cooperate to block infection of murine hepatocytes by human-tropic hepatitis C virus.
Hepatitis C virus (HCV) has no animal reservoir, infecting only humans. To investigate species barrier determinants limiting infecti
Hepatitis C virus (HCV) has no animal reservoir, infecting only humans. To investigate species barrier determinants limiting infecti