Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Dorothea, Rudolph"'
Autor:
Xiaoguang, Hao, Ravinder, Bahia, Orsolya, Cseh, Danielle, Bozek, Sophia, Blake, Jörg, Rinnenthal, Ulrike, Weyer-Czernilofsky, Dorothea, Rudolph, H Artee, Luchman
Publikováno v:
Neuro-Oncology. 25:913-926
Background The tumor suppressor TP53 (p53) is frequently mutated, and its downstream effectors inactivated in many cancers, including glioblastoma (GBM). In tumors with wild-type status, p53 function is frequently attenuated by alternate mechanisms i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2daa7ac7c97de0e6acebabac00b4cb3b
https://doi.org/10.1093/neuonc/noac271
https://doi.org/10.1093/neuonc/noac271
Autor:
Joachim Bröker, Alex G. Waterson, Chris Smethurst, Dirk Kessler, Jark Böttcher, Moriz Mayer, Gerhard Gmaschitz, Jason Phan, Andrew Little, Jason R. Abbott, Qi Sun, Michael Gmachl, Dorothea Rudolph, Heribert Arnhof, Klaus Rumpel, Fabio Savarese, Thomas Gerstberger, Nikolai Mischerikow, Matthias Treu, Lorenz Herdeis, Tobias Wunberg, Andreas Gollner, Harald Weinstabl, Andreas Mantoulidis, Oliver Krämer, Darryl B. McConnell, Stephen W. Fesik
Publikováno v:
Journal of Medicinal Chemistry. 65:14614-14629
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4c212d783bab500794ca19ea0996c93
https://doi.org/10.1021/acs.jmedchem.2c01120
https://doi.org/10.1021/acs.jmedchem.2c01120
Autor:
Nina Kerres, Steffen Steurer, Stefanie Schlager, Gerd Bader, Helmut Berger, Maureen Caligiuri, Christian Dank, John R. Engen, Peter Ettmayer, Bernhard Fischerauer, Gerlinde Flotzinger, Daniel Gerlach, Thomas Gerstberger, Teresa Gmaschitz, Peter Greb, Bingsong Han, Elizabeth Heyes, Roxana E. Iacob, Dirk Kessler, Heike Kölle, Lyne Lamarre, David R. Lancia, Simon Lucas, Moriz Mayer, Katharina Mayr, Nikolai Mischerikow, Katja Mück, Christoph Peinsipp, Oliver Petermann, Ulrich Reiser, Dorothea Rudolph, Klaus Rumpel, Carina Salomon, Dirk Scharn, Renate Schnitzer, Andreas Schrenk, Norbert Schweifer, Diane Thompson, Elisabeth Traxler, Roland Varecka, Tilman Voss, Alexander Weiss-Puxbaum, Sandra Winkler, Xiaozhang Zheng, Andreas Zoephel, Norbert Kraut, Darryl McConnell, Mark Pearson, Manfred Koegl
Publikováno v:
Cell Reports, Vol 20, Iss 12, Pp 2860-2875 (2017)
The transcription factor BCL6 is a known driver of oncogenesis in lymphoid malignancies, including diffuse large B cell lymphoma (DLBCL). Disruption of its interaction with transcriptional repressors interferes with the oncogenic effects of BCL6. We
Externí odkaz:
https://doaj.org/article/43ac770ae3294c078849cf3143253f8a
Autor:
Dongsung Kim, Lorenz Herdeis, Dorothea Rudolph, Yulei Zhao, Jark Böttcher, Alberto Vides, Carlos I. Ayala-Santos, Yasin Pourfarjam, Antonio Cuevas-Navarro, Jenny Y. Xue, Andreas Mantoulidis, Joachim Bröker, Tobias Wunberg, Otmar Schaaf, Johannes Popow, Bernhard Wolkerstorfer, Katrin Gabriele Kropatsch, Rui Qu, Elisa de Stanchina, Ben Sang, Chuanchuan Li, Darryl B. McConnell, Norbert Kraut, Piro Lito
Publikováno v:
Nature.
KRAS is one of the most commonly mutated proteins in cancer, and efforts to directly inhibit its function have been continuing for decades. The most successful of these has been the development of covalent allele-specific inhibitors that trap KRAS G1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::409e1bd71739f2699717b05ba38036b5
https://doi.org/10.1038/s41586-023-06123-3
https://doi.org/10.1038/s41586-023-06123-3
Autor:
Günther R. Adolf, Jens Quant, Norbert Kraut, Guido Boehmelt, Pilar Garin-Chesa, Ulrich Reiser, Matthias Treu, Andreas Zoephel, Gerd Bader, Flavio Solca, Irene C. Waizenegger, Ulrike Tontsch-Grunt, Christian Haslinger, Eva Strauss, Rosa Baumgartinger, Dorothea Rudolph, Christoph Baumann, Stephan K. Zahn, Ulrich Gürtler, Patrizia Sini
Chemical structure of BI 811283: 2,3-diamino-pyrimidine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24b569a67ee6db1fdbb4b9b9898d09fa
https://doi.org/10.1158/1535-7163.22503072
https://doi.org/10.1158/1535-7163.22503072
Autor:
Günther R. Adolf, Jens Quant, Norbert Kraut, Guido Boehmelt, Pilar Garin-Chesa, Ulrich Reiser, Matthias Treu, Andreas Zoephel, Gerd Bader, Flavio Solca, Irene C. Waizenegger, Ulrike Tontsch-Grunt, Christian Haslinger, Eva Strauss, Rosa Baumgartinger, Dorothea Rudolph, Christoph Baumann, Stephan K. Zahn, Ulrich Gürtler, Patrizia Sini
Supplementary Table S1: Statistics of data collection and processing of AuroraB/INCENP in complex with BI 847325; Supplementary Table S2: Statistics of data collection and processing of MEK1 in complex with BI 847325; Supplementary Table S3: Statisti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a674f9a24129289384fc2594456c5203
https://doi.org/10.1158/1535-7163.22503057
https://doi.org/10.1158/1535-7163.22503057
Autor:
Günther R. Adolf, Jens Quant, Norbert Kraut, Guido Boehmelt, Pilar Garin-Chesa, Ulrich Reiser, Matthias Treu, Andreas Zoephel, Gerd Bader, Flavio Solca, Irene C. Waizenegger, Ulrike Tontsch-Grunt, Christian Haslinger, Eva Strauss, Rosa Baumgartinger, Dorothea Rudolph, Christoph Baumann, Stephan K. Zahn, Ulrich Gürtler, Patrizia Sini
(A), MEK1 and phospho-MEK1/2; (B) ERK1/2 and phospho-ERK1/2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::364401e0cf33e13f4ddf75ae3b69dd1f
https://doi.org/10.1158/1535-7163.22503066.v1
https://doi.org/10.1158/1535-7163.22503066.v1
Autor:
Günther R. Adolf, Jens Quant, Norbert Kraut, Guido Boehmelt, Pilar Garin-Chesa, Ulrich Reiser, Matthias Treu, Andreas Zoephel, Gerd Bader, Flavio Solca, Irene C. Waizenegger, Ulrike Tontsch-Grunt, Christian Haslinger, Eva Strauss, Rosa Baumgartinger, Dorothea Rudolph, Christoph Baumann, Stephan K. Zahn, Ulrich Gürtler, Patrizia Sini
(A), MEK1 and phospho-MEK1/2; (B) ERK1/2 and phospho-ERK1/2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ea465e8bb386c7526ee890a39c10857
https://doi.org/10.1158/1535-7163.22503069.v1
https://doi.org/10.1158/1535-7163.22503069.v1
Autor:
Günther R. Adolf, Jens Quant, Norbert Kraut, Guido Boehmelt, Pilar Garin-Chesa, Ulrich Reiser, Matthias Treu, Andreas Zoephel, Gerd Bader, Flavio Solca, Irene C. Waizenegger, Ulrike Tontsch-Grunt, Christian Haslinger, Eva Strauss, Rosa Baumgartinger, Dorothea Rudolph, Christoph Baumann, Stephan K. Zahn, Ulrich Gürtler, Patrizia Sini
(A), MEK1 and phospho-MEK1/2; (B) ERK1/2 and phospho-ERK1/2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e7900c0b469b7183181eea3504d39d1
https://doi.org/10.1158/1535-7163.22503063
https://doi.org/10.1158/1535-7163.22503063
Autor:
Günther R. Adolf, Jens Quant, Norbert Kraut, Guido Boehmelt, Pilar Garin-Chesa, Ulrich Reiser, Matthias Treu, Andreas Zoephel, Gerd Bader, Flavio Solca, Irene C. Waizenegger, Ulrike Tontsch-Grunt, Christian Haslinger, Eva Strauss, Rosa Baumgartinger, Dorothea Rudolph, Christoph Baumann, Stephan K. Zahn, Ulrich Gürtler, Patrizia Sini
BomTac:NMRI-Foxn1nu mice bearing human MIAPaCa-2 tumors were treated with vehicle, BI 847325 at 10 mg/kg daily p.o., AZD6244 at 25 mg/kg twice daily p.o., GSK 1120212 at 0.25 mg/kg twice daily p.o. Data is plotted as average tumor volume with standar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7bfd5ae2616333b34e1ecb62821f3e
https://doi.org/10.1158/1535-7163.22503060.v1
https://doi.org/10.1158/1535-7163.22503060.v1