Melanoma Cell Adhesion and Migration Is Modulated by the Uronyl 2-O Sulfotransferase.

Autor: Katerina Nikolovska, Dorothe Spillmann, Jörg Haier, Andrea Ladányi, Christian Stock, Daniela G Seidler

Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0170054 (2017)

Although the vast majority of melanomas are characterized by a high metastatic potential, if detected early, melanoma can have a good prognostic outcome. However, once metastasised, the prognosis is bleak. We showed previously that uronyl-2-O sulfotr

Externí odkaz: https://doaj.org/article/956da1a625174f19a3b41ee9d51e0c69

Release of sequestered malaria parasites upon injection of a glycosaminoglycan.

Autor: Anna M Vogt, Fredrik Pettersson, Kirsten Moll, Cathrine Jonsson, Johan Normark, Ulf Ribacke, Thomas G Egwang, Hans-Peter Ekre, Dorothe Spillmann, Qijun Chen, Mats Wahlgren

Publikováno v: PLoS Pathogens, Vol 2, Iss 9, p e100 (2006)

Severe human malaria is attributable to an excessive sequestration of Plasmodium falciparum-infected and uninfected erythrocytes in vital organs. Strains of P. falciparum that form rosettes and employ heparan sulfate as a host receptor are associated

Externí odkaz: https://doaj.org/article/9e6edd5f357542fc87eb4dbde1b9e79e

Characterization of Glycosaminoglycan (GAG) Sulfatases from the Human Gut Symbiont Bacteroides thetaiotaomicron Reveals the First GAG-specific Bacterial Endosulfatase

Autor: Olivier Berteau, Pierre-Alexandre Driguez, Jonathan E. Ulmer, Annie Malleron, Corine Sandström, Eric Morssing Vilén, Ramesh Babu Namburi, Alhosna Benjdia, Julie Beneteau, Karine Descroix, Christine Le Narvor, Lassalle Gilbert, Dorothe Spillmann, David Bonnaffé

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2014, 289 (35), pp.24289-24303. ⟨10.1074/jbc.M114.573303⟩
Journal of Biological Chemistry 35 (289), 24289-24303. (2014)

Background: Sulfatases are emerging as key adaptive tools of commensal bacteria to their host. Results: The first bacterial endo-O-sulfatase and three exo-O-sulfatases from the human commensal Bacteroides thetaiotaomicron, specific for glycosaminogly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04780036118e2b0a8f892598b14a6a55
https://doi.org/10.1074/jbc.m114.573303

A Visualizable Chain-Terminating Inhibitor of Glycosaminoglycan Biosynthesis in Developing Zebrafish

Autor: Nicolas L. Derr, Joachim Kuhn, Carolyn R. Bertozzi, Dorothe Spillmann, Johann K. Eberhart, Karen W. Dehnert, Brendan J. Beahm, Sharon L. Amacher

Publikováno v: Angewandte Chemie. 126:3415-3420

Heparan sulfate (HS) and chondroitin sulfate (CS) glycosaminoglycans (GAG) are proteoglycan-associated polysaccharides with essential functions in animals. They have been studied extensively by genetic manipulation of biosynthetic enzymes, but chemic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1faedf6998ac687d2d393b718184de93
https://doi.org/10.1002/ange.201310569

MicroRNA-24 Suppression of N-Deacetylase/N-Sulfotransferase-1 (NDST1) Reduces Endothelial Cell Responsiveness to Vascular Endothelial Growth Factor A (VEGFA)

Autor: Pär Gerwins, Anna Eriksson, Peder Fredlund Fuchs, Zsolt Kasza, Sébastien Le Jan, Christoffer Tamm, Inger Eriksson, Dorothe Spillmann, Paul O'Callaghan, Erik Larsson, Johan Kreuger, Lena Kjellén, Femke Heindryckx

Publikováno v: Journal of Biological Chemistry. 288:25956-25963

Heparan sulfate (HS) proteoglycans, present at the plasma membrane of vascular endothelial cells, bind to the angiogenic growth factor VEGFA to modulate its signaling through VEGFR2. The interactions between VEGFA and proteoglycan co-receptors requir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a4005789a1ae96eb3bd750710e166d
https://doi.org/10.1074/jbc.m113.484360