Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Dorothée Ziegler"'
Autor:
Alexandre Desaintjean, Paul Knochel, Eva Hevia, Dorothée Ziegler, Moritz Balkenhohl, Alan R. Kennedy, Leonie J. Bole
Publikováno v:
Angewandte Chemie. 131:13030-13034
Publikováno v:
Synthesis. 50:4383-4394
A regioselective magnesiation of the 2-pyrone scaffold was developed. Magnesiation of this heterocycle by using TMPMgCl·LiCl (TMP = 2,2,6,6-tetramethylpiperidyl) followed by trapping reactions with electrophiles such as aldehydes, allylic bromides,
Publikováno v:
Angewandte Chemie International Edition. 57:6701-6704
The alkylmagnesium alkoxide sBuMgOR center dot LiOR (R=2-ethylhexyl), which was prepared as a 1.5?m solution in toluene, undergoes very fast Br/Mg exchange with aryl and heteroaryl bromides, producing aryl and heteroaryl magnesium alkoxides (ArMgOR c
Publikováno v:
Angewandte Chemie. 130:6811-6815
Autor:
Denise Cibu, Thomas Bein, Dorothée Ziegler, Florian Auras, Paul Knochel, Robert Greiner, Andreas C. Jakowetz
Publikováno v:
Organic Letters
CoCl2 (5%) catalyzes cross-couplings of various halogenated naphthyridines with alkyl- and arylmagnesium halides. Also, arylzinc halides undergo smooth cross-couplings with various naphthyridines in the presence of CoCl2·2LiCl (5%) and sodium format
Autor:
Robert Greiner, Henning Lumpe, Dorothée Ziegler, Laura Kqiku, Konstantin Karaghiosoff, Paul Knochel
Publikováno v:
Organic Letters. 19:5760-5763
A regioselective zincation of the 2-pyridone and 2,7-naphthyridone scaffolds has been developed. Zincations of the methoxyethoxymethyl (MEM)-protected compounds using TMP2Zn·2MgCl2·2LiCl (TMP = 2,2,6,6-tetramethylpiperidyl) followed by trapping wit
Publikováno v:
Synlett. 28:2817-2822
A mild and general metalation procedure for the functionalization of 1,2-dicyanobenzene and related polyfunctionalized benzonitriles using a commercially available continuous flow setup is reported. The addition of TMPLi (TMP = 2,2,6,6-tetramethylpip
Publikováno v:
Organic Process Research & Development. 21:660-663
Chromones are efficiently zincated in position C(3) in THF by using the commercially available amide base TMPZnCl·LiCl (TMP = 2,2,6,6-tetramethylpiperidyl). Additionally, in the presence of a Lewis acid such as MgCl2, zincation using TMPZnCl·LiCl o
Preparation of Polyfunctional Arylzinc Organometallics in Toluene by Halogen/Zinc Exchange Reactions
Autor:
Alan R. Kennedy, Dorothée Ziegler, Leonie J. Bole, Alexandre Desaintjean, Eva Hevia, Moritz Balkenhohl, Paul Knochel
Publikováno v:
Angewandte Chemie (International ed. in English). 58(37)
A wide range of polyfunctional diaryl-and diheteroarylzinc species were prepared in toluene within 10 min to 5 h through an I/Zn or Br/Zn exchange reaction using bimetallic reagents of the general formula R’2Zn·2LiOR (R’=sBu, tBu, pTol). Highly
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 25(11)
This Minireview describes the scope of the halogen-magnesium exchange. It shows that the use of the turbo-Grignard reagent (iPrMgCl⋅LiCl) greatly enhances the rate of the Br- and I-Mg exchange. Furthermore, this magnesium reagent allows the perform