Výsledky vyhledávání - "Dorothée, Buttigieg"

Akademický článek

Modeling amyotrophic lateral sclerosis in pure human iPSc-derived motor neurons isolated by a novel FACS double selection technique

Autor: Diana Toli, Dorothée Buttigieg, Stéphane Blanchard, Thomas Lemonnier, Boris Lamotte d’Incamps, Sarah Bellouze, Gilbert Baillat, Delphine Bohl, Georg Haase

Publikováno v: Neurobiology of Disease, Vol 82, Iss , Pp 269-280 (2015)

Amyotrophic lateral sclerosis (ALS) is a severe and incurable neurodegenerative disease. Human motor neurons generated from induced pluripotent stem cells (iPSc) offer new perspectives for disease modeling and drug testing in ALS. In standard iPSc-de

Externí odkaz: https://doaj.org/article/127b0c1de7534dae9c254c3dc12a0a5d

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In Vitro and In Vivo Neuroprotective Effects of Etifoxine in β-Amyloidinduced Toxicity Models

Autor: Johann Meunier, Marc Verleye, Vanessa Villard, Dorothée Buttigieg, Véronique Riban

Publikováno v: CNS & Neurological Disorders - Drug Targets. 19:227-240

Aim: The aim of this study is to examine the effect of etifoxine on β-amyloid-induced toxicity models. Background: Etifoxine is an anxiolytic compound with a dual mechanism of action; it is a positive allosteric modulator of GABAergic receptors as w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae2a9851a9bcb59a1b8a5cd0957cf1da
https://doi.org/10.2174/1871527319666200601151007

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Pimavanserin Promotes Trophic Factor Release and Protects Cultured Primary Dopaminergic Neurons Exposed to MPP+ in a GDNF-Dependent Manner

Autor: Dorothée Buttigieg, Rémy Steinschneider, Elodie Gras Lavigne, Ethan S. Burstein

Publikováno v: ACS chemical neuroscience. 12(12)

Neurodegeneration and impaired neural development are a common feature of many neuropsychiatric disorders. Second-generation antipsychotics (SGAs) and certain atypical antidepressants display neuroprotective effects. Though these drugs interact with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ea5b2f737ebfdbabeed6472829002d0
https://pubmed.ncbi.nlm.nih.gov/34032411

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Neuroprotective activity of stiripentol with a possible involvement of voltage-dependent calcium and sodium channels

Autor: Dorothée Buttigieg, Marc Verleye, Rémy Steinschneider

Publikováno v: Journal of Neuroscience Research. 94:179-189

A growing body of data has shown that recurrent epileptic seizures may be caused by an excessive release of the excitatory neurotransmitter glutamate in the brain. Glutamatergic overstimulation results in massive neuronal influxes of calcium and sodi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::acdb7dd58ee8c5cb9347cde8b2998061
https://doi.org/10.1002/jnr.23688

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Modeling amyotrophic lateral sclerosis in pure human iPSc-derived motor neurons isolated by a novel FACS double selection technique

Autor: Dorothée Buttigieg, Stéphane Blanchard, Diana Toli, Delphine Bohl, Georg Haase, Gilbert Baillat, Sarah Bellouze, Thomas Lemonnier, Boris Lamotte d'Incamps

Publikováno v: Neurobiology of Disease, Vol 82, Iss, Pp 269-280 (2015)
Neurobiology of Disease
Neurobiology of Disease, Elsevier, 2015, 82, pp.269-280. ⟨10.1016/j.nbd.2015.06.011⟩
Neurobiology of Disease, 2015, 82, pp.269-280. ⟨10.1016/j.nbd.2015.06.011⟩

International audience; Amyotrophic lateral sclerosis (ALS) is a severe and incurable neurodegenerative disease. Human motor neurons generated from induced pluripotent stem cells (iPSc) offer new perspectives for disease modeling and drug testing in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c65ffa44a284ec8da4026ffb27e4be6
https://doi.org/10.1016/j.nbd.2015.06.011

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Novel combinatorial screening identifies neurotrophic factors for selective classes of motor neurons

Autor: Sébastien Schaller, Alysson Alory, Georg Haase, Marc Barad, Arnaud Jacquier, Mark Merchant, Pierre de la Grange, David Gentien, Dorothée Buttigieg

Publikováno v: Proceedings of the National Academy of Sciences. 114

Numerous neurotrophic factors promote the survival of developing motor neurons but their combinatorial actions remain poorly understood; to address this, we here screened 66 combinations of 12 neurotrophic factors on pure, highly viable, and standard

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae2ed078e6991f400bfdd3177b8a4f1
https://doi.org/10.1073/pnas.1615372114

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Golgi fragmentation in pmn mice is due to a defective ARF1/TBCE cross-talk that coordinates COPI vesicle formation and tubulin polymerization

Autor: Dorothée Buttigieg, Gilbert Baillat, Catherine Rabouille, Georg Haase, Michael K. E. Schäfer, Sarah Bellouze

Publikováno v: Human Molecular Genetics, 23(22), 5961-75. Oxford University Press

Golgi fragmentation is an early hallmark of many neurodegenerative diseases but its pathophysiological relevance and molecular mechanisms are unclear. We here demonstrate severe and progressive Golgi fragmentation in motor neurons of progressive moto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::042bc38416207f169cae5f2992897a7b
https://doi.org/10.1093/hmg/ddu320

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Stathmin 1/2-triggered microtubule loss mediates Golgi fragmentation in mutant SOD1 motor neurons

Autor: Georg Haase, Catherine Rabouille, Dorothée Buttigieg, Gilbert Baillat, Pierre de la Grange, Sarah Bellouze

Publikováno v: Molecular Neurodegeneration
Molecular Neurodegeneration, BioMed Central, 2016, 11, pp.43. ⟨10.1186/s13024-016-0111-6⟩
Molecular Neurodegeneration, 2016, 11, pp.43. ⟨10.1186/s13024-016-0111-6⟩
Molecular Neurodegeneration, 11(1). BioMed Central
Molecular Neurodegeneration [E], 11(1). BioMed Central

Background Pathological Golgi fragmentation represents a constant pre-clinical feature of many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) but its molecular mechanisms remain hitherto unclear. Results Here, we show that t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c22dc7d9000feb9f1f2d15617ffabf7e
https://hal-amu.archives-ouvertes.fr/hal-01463801