Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Dorota Wypych"'
Autor:
Aneta M. Dobosz, Justyna Janikiewicz, Ewelina Krogulec, Anna Dziewulska, Anna Ajduk, Marcin Szpila, Hanna Nieznańska, Andrzej A. Szczepankiewicz, Dorota Wypych, Agnieszka Dobrzyn
Publikováno v:
Molecular Metabolism, Vol 67, Iss , Pp 101659- (2023)
Abnormalities that characterize the pathophysiology of type 2 diabetes (T2D) include deficiencies of β-cells and the expansion of α-cells in pancreatic islets, manifested by lower insulin release and glucagon oversecretion. The molecular mechanisms
Externí odkaz:
https://doaj.org/article/93b47b0cfaee40919c316cd1cf33440e
Publikováno v:
Journal of Visualized Experiments.
Cryogenic electron microscopy (cryoEM) has become an integral part of many drug-discovery projects because crystallography of the protein target is not always achievable and cryoEM provides an alternative means to support structure-based ligand desig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a74c7c965eb7ecf460546e0dc3694a
https://doi.org/10.3791/62377
https://doi.org/10.3791/62377
Autor:
Dorota Wypych, Jolanta Barańska
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9783030306502
Advances in Experimental Medicine and Biology ISBN: 9789400747180
Advances in Experimental Medicine and Biology ISBN: 9789400747180
The chapter is focused on the mechanism of action of metabotropic P2Y nucleotide receptors: P2Y1, P2Y2, P2Y12, P2Y14 and the ionotropic P2X7 receptor in glioma C6 cells. P2Y1 and P2Y12 both respond to ADP, but while P2Y1 links to PLC and elevates cyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d284c72e216ed71a2b9e522367b4b808
https://doi.org/10.1007/978-3-030-30651-9_3
https://doi.org/10.1007/978-3-030-30651-9_3
Autor:
Dorota Wypych, Paweł Pomorski
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9783030306502
Advances in Experimental Medicine and Biology ISBN: 9789400747180
Advances in Experimental Medicine and Biology ISBN: 9789400747180
Calcium signaling is probably one of the evolutionary oldest and the most common way by which the signal can be transmitted from the cell environment to the cytoplasmic calcium binding effectors. Calcium signal is fast and due to diversity of calcium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::721de4b93593f18f11541091d4828476
https://doi.org/10.1007/978-3-030-30651-9_4
https://doi.org/10.1007/978-3-030-30651-9_4
Autor:
Marta Fumagalli, Paolo Gelosa, Claudia Verderio, Elham Nikookhesal, Elena Tremoli, Mauro Cimino, Alice Pignieri, Davide Lecca, Maria P. Abbracchio, Dorota Wypych, Luigi Sironi, Malin Enerbäck
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 34:979-988
The ADP-responsive P2Y12 receptor is expressed on both platelets and microglia. Clinical data show that ticagrelor, a direct-acting, reversibly binding P2Y12-receptor antagonist, reduces total cardiovascular events, including stroke. In our present s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddaae61f84b7fcf294d010819a953f95
https://doi.org/10.1038/jcbfm.2014.45
https://doi.org/10.1038/jcbfm.2014.45
Autor:
Dorota, Wypych
Publikováno v:
Postepy biochemii. 60(4)
Newly identified metabotropic GPR17 receptors are structurally related to purinergic P2Y receptors and cysteinyl leukotriene receptors. Re- cent studies showed that they play an important role in maturation of oligodendrocyte precursor cells. This re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2714af973c2191b958020f210fa8d038
https://pubmed.ncbi.nlm.nih.gov/25807830
https://pubmed.ncbi.nlm.nih.gov/25807830
Autor:
Paweł Pomorski, Dorota Wypych
Publikováno v:
Acta biochimica Polonica. 59(4)
In our earlier studies of the signaling cross-talk between nucleotide receptors in an in vitro glioma model (C6 cell line) under prolonged serum deprivation conditions, a growth arrest of the cells and expression shift from P2Y(1) to P2Y(12) receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72636add62d873702913ff64382a68a8
https://pubmed.ncbi.nlm.nih.gov/23256092
https://pubmed.ncbi.nlm.nih.gov/23256092
Autor:
Dorota, Wypych, Jolanta, Barańska
Publikováno v:
Advances in experimental medicine and biology. 986
The chapter is focused on the mechanism of action of metabotropic P2Y nucleotide receptors: P2Y(1), P2Y(2), P2Y(12), P2Y(14) and the ionotropic P2X(7) receptor in glioma C6 cells. P2Y(1) and P2Y(12) both respond to ADP, but while P2Y(1) links to PLC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::64b536e3bef29749e4977c7c60e116ef
https://pubmed.ncbi.nlm.nih.gov/22879063
https://pubmed.ncbi.nlm.nih.gov/22879063
Publikováno v:
Scopus-Elsevier
Glyconeogenesis, the synthesis of glycogen from carbohydrate precursors like lactate, seems to be an important pathway participating in replenishing glycogen in cardiomyocytes. Fructose-1,6-bisphosphatase (FBPase), an indispensible enzyme of glyconeo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db11645493ecee86c5785fa1dcb72e6
https://doi.org/10.18388/abp.2010_2450
https://doi.org/10.18388/abp.2010_2450
Autor:
Paweł Pomorski, Patryk Krzemiński, A. Wasik, Katarzyna Sobierajska, Jarosław Korczyński, Wanda Kłopocka, Dorota Wypych
Publikováno v:
Scopus-Elsevier
Europe PubMed Central
Europe PubMed Central
Inhibition of Rho-associated protein kinase (ROCK) activity in glioma C6 cells induces changes in actin cytoskeleton organization and cell morphology similar to those observed in other types of cells with inhibited RhoA/ROCK signaling pathway. We sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5d3259fcded3939c6808c75cc1f241
http://www.scopus.com/inward/record.url?eid=2-s2.0-79953199085&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-79953199085&partnerID=MN8TOARS