Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Dorota Szpak"'
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract Metastasis is the main cause of death in cancer patients, including breast cancer (BC). Despite recent progress in understanding the biological and molecular determinants of BC metastasis, effective therapeutic treatments are yet to be devel
Externí odkaz:
https://doaj.org/article/d9e7d9b1f90f44759827faaae4b78ccd
Autor:
Dorota Szpak, Chloe Turpin, Utku Goreke, Katarzyna Bialkowska, Kamila M. Bledzka, Dmitriy Verbovetskiy, Narla Mohandas, Umut A. Gurkan, Jun Qin, Edward F. Plow, Elzbieta Pluskota
Publikováno v:
Blood Advances. 7:1739-1753
Kindlin-3 (K3) is critical for the activation of integrin adhesion receptors in hematopoietic cells. In humans and mice, K3 deficiency is associated with impaired immunity and bone development, bleeding, and aberrant erythrocyte shape. To delineate h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee9044a4660faf3cf35f8417e551bdcd
https://doi.org/10.1182/bloodadvances.2022008498
https://doi.org/10.1182/bloodadvances.2022008498
Autor:
Edward F. Plow, William P. Schiemann, Daniel J. Lindner, Chevaun D. Morrison, Yvonne Parker, Dorota Szpak, Katarzyna Bialkowska, Elzbieta Pluskota, Khalid Sossey-Alaoui
This Figure reports Kaplan-Meier plot correlating survival of 3951 breast cancer patients with CSF-1 expression levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de13a2b2e9690e1f5448985b52501996
https://doi.org/10.1158/0008-5472.22415430
https://doi.org/10.1158/0008-5472.22415430
Autor:
Edward F. Plow, William P. Schiemann, Daniel J. Lindner, Chevaun D. Morrison, Yvonne Parker, Dorota Szpak, Katarzyna Bialkowska, Elzbieta Pluskota, Khalid Sossey-Alaoui
Interplay between tumor cells and host cells in the tumor microenvironment dictates the development of all cancers. In breast cancer, malignant cells educate host macrophages to adopt a protumorigenic phenotype. In this study, we show how the integri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99462ba05d196cb993473e3b97898e36
https://doi.org/10.1158/0008-5472.c.6509292.v1
https://doi.org/10.1158/0008-5472.c.6509292.v1
Autor:
Lahoucine Izem, Dmitry A. Soloviev, Elzbieta Pluskota, Valentin P. Yakubenko, Dmitriy Verbovetskiy, Dorota Szpak
Publikováno v:
The Journal of Immunology. 200:2426-2438
Atherosclerosis is a complex inflammatory process characterized by monocyte recruitment into the arterial wall, their differentiation into macrophages and lipid accumulation. Since integrin α(M)β(2) (CD11b/CD18) mediates multiple diverse functions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2215bd1f078d27c2769b3a3fb5bacb10
https://doi.org/10.4049/jimmunol.1700313
https://doi.org/10.4049/jimmunol.1700313
Autor:
Dmitry A. Soloviev, Edward F. Plow, Katarzyna Bialkowska, Elzbieta Pluskota, Dmitriy Verbovetskiy, Dorota Szpak, Sidney V. Jones, Kamila Bledzka
Publikováno v:
The Journal of Physiology. 595:6443-6462
Key points A reduction in Kindlin-2 levels in endothelial cells compromises vascular barrier function. Kindlin-2 is a previously unrecognized component of endothelial adherens junctions. By interacting directly and simultaneously with β- or γ-caten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88711f17fe337d5ed1e8263f8372bf3b
https://doi.org/10.1113/jp274380
https://doi.org/10.1113/jp274380
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 10, Iss 8, Pp 1-16 (2019)
Cell Death and Disease, Vol 10, Iss 8, Pp 1-16 (2019)
In cancer, cellular senescence is a complex process that leads to inhibition of proliferation of cells that may develop a neoplastic phenotype. A plethora of signaling pathways, when dysregulated, have been shown to elicit a senescence response. Two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5bfc8579740453300cb17e4d53b5b16
https://pubmed.ncbi.nlm.nih.gov/31308359
https://pubmed.ncbi.nlm.nih.gov/31308359
Autor:
Krzysztof, Ciszowski, Ewa, Gomółka, Tomasz, Gawlikowski, Dorota, Szpak, Anna, Potoczek, Magdalena, Boba
Publikováno v:
Przeglad lekarski. 73(8)
Neurotrophins are the family of proteins which stimulate and regulate the process of neurogenesis. Several factors belong to the family, mainly nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT 3), and neurotroph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::49438d981a45b475d118d93bea4fc89f
https://pubmed.ncbi.nlm.nih.gov/29677430
https://pubmed.ncbi.nlm.nih.gov/29677430
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Metastasis is the main cause of death in cancer patients, including breast cancer (BC). Despite recent progress in understanding the biological and molecular determinants of BC metastasis, effective therapeutic treatments are yet to be developed. Amo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b15ed8750827cdd3050395ee9d115fd0
https://pubmed.ncbi.nlm.nih.gov/29743493
https://pubmed.ncbi.nlm.nih.gov/29743493
Autor:
Elzbieta, Pluskota, Kamila M, Bledzka, Katarzyna, Bialkowska, Dorota, Szpak, Dmitry A, Soloviev, Sidney V, Jones, Dmitriy, Verbovetskiy, Edward F, Plow
Publikováno v:
The Journal of physiology. 595(20)
A reduction in Kindlin-2 levels in endothelial cells compromises vascular barrier function. Kindlin-2 is a previously unrecognized component of endothelial adherens junctions. By interacting directly and simultaneously with β- or γ-catenin and cort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::32fb888589f0ae8cea5a0dce5d4e0683
https://pubmed.ncbi.nlm.nih.gov/28833162
https://pubmed.ncbi.nlm.nih.gov/28833162