Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Dorota Sabat"'
Autor:
Dorota Sabat‐Pośpiech, Kim Fabian‐Kolpanowicz, Helen Kalirai, Natalie Kipling, Sarah E Coupland, Judy M Coulson, Andrew B Fielding
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 8, Iss 4, Pp 383-394 (2022)
Abstract Uveal melanoma (UM) is the most common intraocular cancer in adults. Whilst treatment of primary UM (PUM) is often successful, around 50% of patients develop metastatic disease with poor outcomes, linked to chromosome 3 loss (monosomy 3, M3)
Externí odkaz:
https://doaj.org/article/e52134711fec4d00857b44a97422ee2d
Autor:
Yamini Krishna, Amelia Acha-Sagredo, Dorota Sabat-Pośpiech, Natalie Kipling, Kim Clarke, Carlos R. Figueiredo, Helen Kalirai, Sarah E. Coupland
Publikováno v:
Cancers, Vol 12, Iss 10, p 2832 (2020)
Metastatic uveal melanoma (mUM) to the liver is incurable. Transcriptome profiling of 40 formalin-fixed paraffin-embedded mUM liver resections and 6 control liver specimens was undertaken. mUMs were assessed for morphology, nuclear BAP1 (nBAP1) expre
Externí odkaz:
https://doaj.org/article/d6cc1c1052c04a6cb4cad74ae2c597c1
Publikováno v:
Translational vision sciencetechnology. 11(12)
Dual-specificity phosphatase 4 (DUSP4) inactivates factors in the mitogen-activated protein kinase (MAPK) signaling cascade, activated in uveal melanoma (UM) by mutations in upstream G-protein α subunits GNAQ/11 in90% cases. This study examined whet
Autor:
Dorota Sabat-Pośpiech, Amelia Acha-Sagredo, Sarah E. Coupland, Helen Kalirai, Yamini Krishna, Natalie Kipling, Carlos R. Figueiredo, Kim Clarke
Publikováno v:
Cancers
Volume 12
Issue 10
Cancers, Vol 12, Iss 2832, p 2832 (2020)
Volume 12
Issue 10
Cancers, Vol 12, Iss 2832, p 2832 (2020)
Metastatic uveal melanoma (mUM) to the liver is incurable. Transcriptome profiling of 40 formalin-fixed paraffin-embedded mUM liver resections and 6 control liver specimens was undertaken. mUMs were assessed for morphology, nuclear BAP1 (nBAP1) expre
Autor:
Marcin Szpila, Takao Ishikawa, Robert Milewski, Anna Ajduk, Katarzyna Szczepanska, Patrycja Strączyńska, Dorota Sabat-Pośpiech, Agnieszka Walewska
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-18 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-18 (2019)
Postovulatory ageing of mammalian oocytes occurs between their ovulation and fertilization and has been shown to decrease their developmental capabilities. Aged oocytes display numerous abnormalities, including altered Ca2+ signalling. Fertilization-
Autor:
Michał Lower, Ewa Bartnik, Ewa Pronicka, Anna Łusakowska, Aneta Kaniak-Golik, Dorota Sabat, Anna Kamińska, Anna Kostera-Pruszczyk, Jakub Kruszewski, Dorota Lutyk, Magdalena Kaliszewska, Biruta Kierdaszuk, Joel Vizueta, Monika Nojszewska, Pawel Golik, Dorota Piekutowska-Abramczuk, Katarzyna Tońska
Publikováno v:
Human Genetics
Replication of the mitochondrial genome depends on the single DNA polymerase (pol gamma). Mutations in the POLG gene, encoding the catalytic subunit of the human polymerase gamma, have been linked to a wide variety of mitochondrial disorders that sho