Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Dorota Miklowski"'
Autor:
Karen Rowan, Jefferson Wright Tilley, Richard V. Trilles, Dorota Miklowski, Virginia Schwinge, Li Chen, Tai-Nan Huang, Robert M. Campbell, David C. Fry
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1679-1682
A structure-based focused library approach was employed in an effort to identify more lipophilic replacements for the N-benzylpyroglutamyl group of the VCAM/VLA-4 antagonist 2. This effort led to the discovery of two new classes of potent antagonists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd7d731fdb244de48ba4c2810efc9ab
https://doi.org/10.1016/s0960-894x(02)00201-9
https://doi.org/10.1016/s0960-894x(02)00201-9
Autor:
Dorota Miklowski, Richard V. Trilles, Robert William Guthrie, Karen Rowan, Gerry Kaplan, Nicolas Huby, Barry A. Wolitzky, Jefferson Wright Tilley, Virginia Schwinge, Francis A. Mennona, Tai-Nan Huang, Li Chen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:729-733
A series of N-(N-benzylpyroglutamyl)-4-substituted-L-phenylalanine derivatives was prepared as VLA-4/VCAM antagonists. Analogues substituted by electron deficient benzoylamino groups bearing bulky ortho substituents had low-nM potency in an ELISA ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d9701ff0e4ce4f658c7cfcb49aaa55f
https://doi.org/10.1016/s0960-894x(00)00089-5
https://doi.org/10.1016/s0960-894x(00)00089-5
Autor:
Hong Yang, Irena Daniewski, Dorota Miklowski, Brian Higgins, Giacomo Pizzolato, Fred Konzelmann, Christine Lukacs, Peter Michael Wovkulich, Rossman Pamela Loreen, Kenneth Kolinsky, Xuefeng Yin, Wei Chung-Chen, Grace Ju, Qingjie Ding, Kshitij Chhabilbhai Thakkar, Amy Swain, Jin-Jun Liu
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(20)
A novel series of pyrazolobenzodiazepines 3 has been identified as potent inhibitors of cyclin-dependent kinase 2 (CDK2). Their synthesis and structure-activity relationships (SAR) are described. Representative compounds from this class reversibly in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3779ce22a7db6be82920da5853d825bf
https://pubmed.ncbi.nlm.nih.gov/20832307
https://pubmed.ncbi.nlm.nih.gov/20832307