Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Dorota K. Pomorska"'
Autor:
Tomasz Janecki, Katarzyna Gach, Marek Mirowski, Anna Janecka, Jakub Modranka, Dorota K. Pomorska, Jacek Szymański, Urszula Krajewska
Publikováno v:
European Journal of Medicinal Chemistry. 120:51-63
In this paper we report an efficient and general synthesis of substituted 3-diethoxyphosphorylnaphtho [2,3-b]furan-4,9-diones and 3-diethoxyphosphorylbenzo [f]indole-4,9-diones which integrate the natural 1,4-naphtalenedione scaffold, present in seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b377bb6f26b50724722fc531e35079
https://doi.org/10.1016/j.ejmech.2016.05.002
https://doi.org/10.1016/j.ejmech.2016.05.002
Publikováno v:
Current Pharmaceutical Design. 22:1361-1370
Energy intake and expenditure are regulated by a complex network of neurochemical systems. The results of numerous studies have provided information about receptors involved, the sites of action within the brain and interactions between various syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c7198cea30ad21aaf2808eeca968a8
https://doi.org/10.2174/1381612822666160125114144
https://doi.org/10.2174/1381612822666160125114144
Autor:
Angelika Długosz, Henryk Krawczyk, Tomasz Janecki, Dorota K. Pomorska, Marek Mirowski, Urszula Krajewska, Krzysztof Huben, Anna Janecka, Dariusz Deredas
Publikováno v:
MedChemComm. 7:1745-1758
A simple and general strategy for the synthesis of 3-methylene-4-(2-oxoalkyl)-3,4-dihydrocoumarins has been developed. The elaborated synthetic protocol includes 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD)- or Cs2CO3-promoted conjugate addition of enol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc55da92607209b8e6b872e64489bde5
https://doi.org/10.1039/c6md00118a
https://doi.org/10.1039/c6md00118a
Autor:
Tomasz Janecki, Anna Janecka, Marek Rozalski, Jakub Modranka, Rafał Jakubowski, Dorota K. Pomorska, Urszula Krajewska, Katarzyna Gach
Publikováno v:
European Journal of Medicinal Chemistry. 92:565-574
Three series of new 4-methylidenepyrazolidin-3-ones with various substitution patterns were synthesized and tested for the cytotoxic activity against two human leukemia cell lines NALM-6 and HL-60 as well as MCF-7 breast cancer cell line. Several obt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ab8bd516835890ddd6624d1465edc56
https://doi.org/10.1016/j.ejmech.2015.01.029
https://doi.org/10.1016/j.ejmech.2015.01.029
Autor:
Anna Janecka, Jacek Kędzia, Marek Rozalski, Dorota K. Pomorska, Tomasz Janecki, Marlena Pięta, Urszula Krajewska
Publikováno v:
RSC Advances. 5:78324-78335
A novel, efficient synthesis of 1,4-disubstituted 3-methylidene-3,4-dihydrodihydroquinolin-2(1H)-ones was accomplished via a three step reaction sequence comprising N-alkylation of 3-diethoxyphosphorylquinolin-2(1H)-one, Michael addition of various G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16045c4312930b66d01597c20640b53d
https://doi.org/10.1039/c5ra16673j
https://doi.org/10.1039/c5ra16673j
Autor:
Anna Janecka, Tomasz Janecki, Rafal Jakubowski, Marek Mirowski, Tomasz Bartosik, Marek Rozalski, Angelika Długosz, Urszula Krajewska, Dorota K. Pomorska
Publikováno v:
ChemMedChem. 12(8)
The synthesis of a new library of 4,4-disubstituted 3-methylidene-3,4-dihydro-2H-chroman-2-ones applying Horner-Wadsworth-Emmons methodology for the construction of an exo-methylidene moiety is reported. Corresponding 3-diethoxyphosphorylchroman-2-on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77adabd99c981790a82955855e1c21ae
https://pubmed.ncbi.nlm.nih.gov/28258688
https://pubmed.ncbi.nlm.nih.gov/28258688
Autor:
Urszula Krajewska, Jacek Kędzia, Marek Rozalski, Marlena Pięta, Anna Janecka, Dorota K. Pomorska, Tomasz Janecki
Publikováno v:
ChemInform. 47
The title compounds are prepared in a 3-step sequence starting from (I) via N-alkylation, Grignard addition and Horner-Wadsworth-Emmons reaction with formaldehyde.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7563181c543c5ca6299acac0c35f3c6
https://doi.org/10.1002/chin.201606181
https://doi.org/10.1002/chin.201606181
Publikováno v:
Mini reviews in medicinal chemistry. 14(14)
The main role of endogenous opioid peptides is the modulation of pain. Opioid peptides exert their analgesic activity by binding to the opioid receptors distributed widely in the central nervous system (CNS). However, opioid receptors are also found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd8b9909498d436ab3ebb480749d1439
https://pubmed.ncbi.nlm.nih.gov/25553430
https://pubmed.ncbi.nlm.nih.gov/25553430