Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Dorota Focht"'
Autor:
Kenneth Atz, Leandro Cotos, Clemens Isert, Maria Håkansson, Dorota Focht, Mattis Hilleke, David F. Nippa, Michael Iff, Jann Ledergerber, Carl C. G. Schiebroek, Valentina Romeo, Jan A. Hiss, Daniel Merk, Petra Schneider, Bernd Kuhn, Uwe Grether, Gisbert Schneider
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract De novo drug design aims to generate molecules from scratch that possess specific chemical and pharmacological properties. We present a computational approach utilizing interactome-based deep learning for ligand- and structure-based generati
Externí odkaz:
https://doaj.org/article/d7bb743be1dc457aa2795efb9109d361
Efficacy of the combination of monoclonal antibodies against the SARS-CoV-2 Beta and Delta variants.
Autor:
Chatikorn Boonkrai, Thomas S Cotrone, Watchadaporn Chaisuriyong, Terapong Tantawichien, Usa Thisyakorn, Stefan Fernandez, Taweewun Hunsawong, Matthew Reed, Tossapon Wongtangprasert, Thittaya Audomsun, Tanapati Phakham, Chadaporn Attakitbancha, Pijitra Saelao, Dorota Focht, Raymond Kimbung, Martin Welin, Aijaz Ahmad Malik, Trairak Pisitkun, Nattachai Srisawat
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0284173 (2023)
The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently the biggest healthcare issue worldwide. This study aimed to develop a monoclonal antibody against SARS-CoV-2 from B cells of recovered COVID-19 patients, which
Externí odkaz:
https://doaj.org/article/f90cda5ef3fd48818ea0a99039882428
Autor:
Akos Nyerges, Tihomir Tomašič, Martina Durcik, Tamas Revesz, Petra Szili, Gabor Draskovits, Ferenc Bogar, Žiga Skok, Nace Zidar, Janez Ilaš, Anamarija Zega, Danijel Kikelj, Lejla Daruka, Balint Kintses, Balint Vasarhelyi, Imre Foldesi, Diána Kata, Martin Welin, Raymond Kimbung, Dorota Focht, Lucija Peterlin Mašič, Csaba Pal
Publikováno v:
PLoS Biology, Vol 18, Iss 10, p e3000819 (2020)
Antibiotics that inhibit multiple bacterial targets offer a promising therapeutic strategy against resistance evolution, but developing such antibiotics is challenging. Here we demonstrate that a rational design of balanced multitargeting antibiotics
Externí odkaz:
https://doaj.org/article/695667e264814dc5919d30b833577001
The bacterial amino acid transporter MhsT of the SLC6A family was crystallized in complex with different substrates in order to understand the determinants of substrate specificity of the transporter. Surprisingly, crystals of the different MhsT-subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7c909130667c08828253b1a6679eb81
https://doi.org/10.1101/2022.05.03.490450
https://doi.org/10.1101/2022.05.03.490450
Autor:
Lejla Daruka, Nace Zidar, Ákos Nyerges, Petra Szili, Žiga Skok, Dorota Focht, Darja Gramec Skledar, Jurij Trontelj, Martina Durcik, Tihomir Tomašič, Lucija Peterlin Mašič, Tamás Révész, Ondřej Benek, Cristina D. Cruz, Danijel Kikelj, Gábor Draskovits, Martin Welin, Csaba Pál, Janez Ilaš, Yengo R. Kimbung, Anamarija Zega, Päivi Tammela
Publikováno v:
European journal of medicinal chemistry, str. 1-22 : Ilustr., Vol. 213, 2021
COBISS-ID: 25429760
Elsevier European Journal of Medicinal Chemistry Volume 213, 5 March 2021, 113200
COBISS-ID: 25429760
Elsevier European Journal of Medicinal Chemistry Volume 213, 5 March 2021, 113200
The rise in multidrug-resistant bacteria defines the need for identification of new antibacterial agents that are less prone to resistance acquisition. Compounds that simultaneously inhibit multiple bacterial targets are more likely to suppress the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fcc7da87a4469eccf6543d826bf645b
https://pubmed.ncbi.nlm.nih.gov/33524686
https://pubmed.ncbi.nlm.nih.gov/33524686
Autor:
Balint Kintses, Danijel Kikelj, Ferenc Bogár, Martina Durcik, Gábor Draskovits, Bálint Vásárhelyi, D Kata, Martin Welin, Janez Ilaš, Petra Szili, Žiga Skok, Raymond Kimbung, Lejla Daruka, Ákos Nyerges, Lucija Peterlin Mašič, Imre Földesi, Csaba Pál, Anamarija Zega, Tamás Révész, Nace Zidar, Tihomir Tomašič, Dorota Focht
Publikováno v:
PLoS biology 18(10), e3000819 (2020). doi:10.1371/journal.pbio.3000819
PLoS biology, str. 1-31 : Ilustr., Vol. 18, iss. 10, 2020
COBISS-ID: 2943764
PLoS biology, vol. 18, no. 10, pp. 1-31, 2020.
PLoS Biology, Vol 18, Iss 10, p e3000819 (2020)
PLoS Biology
PLOS Biology
PLoS biology, str. 1-31 : Ilustr., Vol. 18, iss. 10, 2020
COBISS-ID: 2943764
PLoS biology, vol. 18, no. 10, pp. 1-31, 2020.
PLoS Biology, Vol 18, Iss 10, p e3000819 (2020)
PLoS Biology
PLOS Biology
Antibiotics that inhibit multiple bacterial targets offer a promising therapeutic strategy against resistance evolution, but developing such antibiotics is challenging. Here we demonstrate that a rational design of balanced multitargeting antibiotics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d4996030faea0085448f4f5ae0b3a3
https://bib-pubdb1.desy.de/record/449700
https://bib-pubdb1.desy.de/record/449700
Autor:
Jolanta Maria Dzik, Dorota Focht, Katarzyna Winiarska, Agata Nowosielska, Michal Grabowski, Adam K. Jagielski, Bartosz Sierakowski, Robert Jarzyna
Publikováno v:
Free Radical Biology and Medicine. 81:13-21
The aim of this study was to elucidate the mechanisms involved in the inhibition of renal gluconeogenesis occurring under conditions of lowered activity of NADPH oxidase (Nox), the enzyme considered to be one of the main sources of reactive oxygen sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::557c007d52034de91d7de1a5a7710760
https://doi.org/10.1016/j.freeradbiomed.2014.12.024
https://doi.org/10.1016/j.freeradbiomed.2014.12.024
Autor:
Jolanta Maria Dzik, Katarzyna Winiarska, Mateusz Labudda, Lukasz Komorowski, Aleksandra Owczarek, Wojciech Bielecki, Dorota Focht, Bartosz Sierakowski
Publikováno v:
Journal of pineal research. 60(1)
Excessive activity of NADPH oxidase (Nox) is considered to be of importance for the progress of diabetic nephropathy. The aim of the study was to elucidate the effect of melatonin, known for its nephroprotective properties, on Nox activity under diab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cc3d9c91b481da60ce82f60f0d761ac
https://pubmed.ncbi.nlm.nih.gov/26514550
https://pubmed.ncbi.nlm.nih.gov/26514550
Autor:
Katarzyna Winiarska, Dorota Focht, Bartosz Sierakowski, Michal Usarek, Marta Orlowska, Krystian Lewandowski
Publikováno v:
Chemico-biological interactions. 218
Apocynin (4'-hydroxy-3'-methoxyacetophenone) is the most commonly used NADPH oxidase (Nox) inhibitor. However, its application raises serious controversies, as the compound has been reported to reveal some prooxidative effects. The aim of this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b40cf635521f6614cb2268d308fd98ba
https://pubmed.ncbi.nlm.nih.gov/24797087
https://pubmed.ncbi.nlm.nih.gov/24797087