Supplemental Figures 1 - 6 from l-Arginine Depletion Blunts Antitumor T-cell Responses by Inducing Myeloid-Derived Suppressor Cells

Autor: Paulo C. Rodriguez, Augusto C. Ochoa, Dorota D. Wyczechowska, Claudia Hernandez, Dulfary Sanchez-Pino, Amir A. Al-Khami, Paul Thevenot, Patrick Raber, Rosa A. Sierra, Maria E. Ramirez, Matthew Fletcher

Supplemental Figure 1. Peg-Arg I blocks T cell proliferation and IFNy production. Supplemental Figure 2. Peg-Arg I does not alter T cell percentages in naive mice. Supplemental Figure 3. Effects of peg-Arg I on T-cell glycolysis. Supplemental Figure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::943db767fe7aea3705d0b57757b7b15e
https://doi.org/10.1158/0008-5472.22407839.v1

Novel immunomodulatory properties of adenosine analogs promote their antiviral activity against SARS-CoV-2.

Autor: Monticone G; Department of Genetics, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA. gmonti@lsuhsc.edu., Huang Z; Department of Genetics, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA., Hewins P; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Cook T; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Mirzalieva O; Department of Biochemistry and Molecular Biology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA., King B; Department of Genetics, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA., Larter K; Department of Genetics, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA., Miller-Ensminger T; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Sanchez-Pino MD; Department of Genetics, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA.; Department of Interdisciplinary Oncology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA., Foster TP; Department of Microbiology, Immunology & Parasitology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA., Nichols OV; Department of Microbiology, Immunology & Parasitology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA., Ramsay AJ; Department of Microbiology, Immunology & Parasitology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA., Majumder S; Department of Genetics, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA., Wyczechowska D; Department of Interdisciplinary Oncology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA., Tauzier D; Precision Medicine Program, Louisiana State University Health Sciences Center, New Orleans, LA, USA.; Department of Pathology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA., Gravois E; Precision Medicine Program, Louisiana State University Health Sciences Center, New Orleans, LA, USA.; Department of Pathology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA., Crabtree JS; Department of Genetics, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA.; Precision Medicine Program, Louisiana State University Health Sciences Center, New Orleans, LA, USA., Garai J; Department of Interdisciplinary Oncology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA., Li L; Department of Interdisciplinary Oncology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA., Zabaleta J; Department of Interdisciplinary Oncology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA., Barbier MT; Department of Interdisciplinary Oncology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA., Del Valle L; Department of Interdisciplinary Oncology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA.; Department of Pathology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA., Jurado KA; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Miele L; Department of Genetics, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA.

Publikováno v: EMBO reports [EMBO Rep] 2024 Aug; Vol. 25 (8), pp. 3547-3573. Date of Electronic Publication: 2024 Jul 15.

IKAROS expression drives the aberrant metabolic phenotype of macrophages in chronic HIV infection.

Autor: Vittori C; Louisiana State University Health Sciences Center and Louisiana Cancer Research Center, New Orleans, LA 70112, USA., Faia C; Louisiana State University Health Sciences Center and Louisiana Cancer Research Center, New Orleans, LA 70112, USA., Wyczechowska D; Louisiana State University Health Sciences Center and Louisiana Cancer Research Center, New Orleans, LA 70112, USA., Trauth A; Louisiana State University Health Sciences Center and Louisiana Cancer Research Center, New Orleans, LA 70112, USA., Plaisance-Bonstaff K; Louisiana State University Health Sciences Center and Louisiana Cancer Research Center, New Orleans, LA 70112, USA., Meyaski-Schluter M; Clinical and Translational Research Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA., Reiss K; Louisiana State University Health Sciences Center and Louisiana Cancer Research Center, New Orleans, LA 70112, USA., Peruzzi F; Louisiana State University Health Sciences Center and Louisiana Cancer Research Center, New Orleans, LA 70112, USA; Louisiana State University Health Sciences Center, Department of Medicine, Louisiana Cancer Research Center; New Orleans, LA 70112, USA. Electronic address: fperuz@lsuhsc.edu.

Publikováno v: Clinical immunology (Orlando, Fla.) [Clin Immunol] 2024 Mar; Vol. 260, pp. 109915. Date of Electronic Publication: 2024 Jan 28.

The Efficacy of CB-103, a First-in-Class Transcriptional Notch Inhibitor, in Preclinical Models of Breast Cancer.

Autor: Vigolo M; Cellestia Biotech AG, 4057 Basel, Switzerland., Urech C; Cellestia Biotech AG, 4057 Basel, Switzerland., Lamy S; Cellestia Biotech AG, 4057 Basel, Switzerland., Monticone G; Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA., Zabaleta J; Department of Interdisciplinary Oncology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA., Hossain F; Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA., Wyczechowska D; Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA., Del Valle L; Department of Pathology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA., O'Regan RM; Department of Medicine, University of Rochester, Rochester, NY 14642, USA., Miele L; Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA., Lehal R; Cellestia Biotech AG, 4057 Basel, Switzerland., Majumder S; Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.

Publikováno v: Cancers [Cancers (Basel)] 2023 Aug 03; Vol. 15 (15). Date of Electronic Publication: 2023 Aug 03.

Correction to: A combination of novel NSC small molecule inhibitor along with doxorubicin inhibits proliferation of triple-negative breast cancer through metabolic reprogramming.

Autor: Yousefi H; Department of Biochemistry & Molecular Biology, Louisiana State University Health Science Center (LSUHSC) School of Medicine, New Orleans, LA, USA., Khosla M; Department of Biochemistry & Molecular Biology, Louisiana State University Health Science Center (LSUHSC) School of Medicine, New Orleans, LA, USA., Lauterboeck L; Department of Pharmacology and Experimental Therapeutics, Cardiovascular Center of Excellence, Louisiana State University Health Science Center (LSUHSC) School of Medicine, New Orleans, LA, USA., Okpechi SC; Department of Biochemistry & Molecular Biology, Louisiana State University Health Science Center (LSUHSC) School of Medicine, New Orleans, LA, USA., Worthylake D; Department of Biochemistry & Molecular Biology, Louisiana State University Health Science Center (LSUHSC) School of Medicine, New Orleans, LA, USA., Garai J; Stanley S. Scott Cancer Center, LSUHSC, New Orleans, LA, USA., Zabaleta J; Department of Interdisciplinary Oncology and Stanley S. Scott Cancer Center, LSUHSC, New Orleans, LA, USA., Guidry J; Proteomics Core facility, Louisiana State University Health Science Center (LSUHSC), New Orleans, LA, USA., Zarandi MA; Department of Chemistry, Tulane University, New Orleans, LA, USA., Wyczechowska D; Stanley S. Scott Cancer Center, LSUHSC, New Orleans, LA, USA., Jayawickramarajah J; Department of Chemistry, Tulane University, New Orleans, LA, USA., Yang Q; Department of Pharmacology and Experimental Therapeutics, Cardiovascular Center of Excellence, Louisiana State University Health Science Center (LSUHSC) School of Medicine, New Orleans, LA, USA., Kissil J; Department of Molecular Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, USA., Alahari SK; Department of Biochemistry & Molecular Biology, Louisiana State University Health Science Center (LSUHSC) School of Medicine, New Orleans, LA, USA. salaha@lsuhsc.edu.

Publikováno v: Oncogene [Oncogene] 2023 Mar; Vol. 42 (11), pp. 859.