Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Dorota Cedzik"'
Autor:
Rajula Gaur, Kofi A. Mensah, Jason Stricker, Mary Adams, Anastasia Parton, Dorota Cedzik, Jamie Connarn, Michael Thomas, Gerald Horan, Peter Schafer, Stuart Mair, Maria Palmisano, Francisco Ramírez-Valle
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-15 (2022)
Abstract Background Mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) is activated downstream of p38 MAPK and regulates stability of mRNAs encoding inflammatory cytokines. CC-99677 is a novel, irreversible, covalent MK2 inhibit
Externí odkaz:
https://doaj.org/article/bbdb650c3cdc4da7b9496d707ec64951
Autor:
Rajula Gaur, Kofi A. Mensah, Jason Stricker, Mary Adams, Anastasia Parton, Dorota Cedzik, Jamie Connarn, Michael Thomas, Gerald Horan, Peter Schafer, Stuart Mair, Maria Palmisano, Francisco Ramírez-Valle
Publikováno v:
Arthritis researchtherapy. 24(1)
Background Mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) is activated downstream of p38 MAPK and regulates stability of mRNAs encoding inflammatory cytokines. CC-99677 is a novel, irreversible, covalent MK2 inhibitor under
Autor:
Peter H. Schafer, Dorota Cedzik, Helen Brady, Jilly F. Evans, G.W. Muller, Anastasia Parton, Man Hw, D.I. Stirling, Rajesh Chopra, Lori Capone
Publikováno v:
Cellular Signalling. 26:2016-2029
Apremilast, an oral small molecule inhibitor of phosphodiesterase 4 (PDE4), is in development for chronic inflammatory disorders, and has shown efficacy in psoriasis, psoriatic arthropathies, and Behçet's syndrome. In March 2014, the US Food and Dru
Autor:
Alice Collette, Rama K. Narla, Heather Raymon, Alexander L. Ruchelman, Hon-Wah Man, Roger Shen-Chu Chen, Jim Leisten, George W. Muller, Ling Lu, Ling Zhang, Wei Liu, Dorota Cedzik
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:6356-6374
A series of 1,1-diarylalkene derivatives were prepared to optimize the properties of CC-5079 (1), a dual inhibitor of tubulin polymerization and phosphodiesterase 4 (PDE4). By using the 3-ethoxy-4-methoxyphenyl PDE4 pharmacophore as one of the aromat
Autor:
Dorota Cedzik, Zhe-ming Gu, Oscar L. Laskin, Anfan Wu, Lori Capone, Sekhar Surapaneni, Peter H. Schafer, Gondi Kumar, Kei-Lai Fong, Dennis Heller, Matthew Hoffmann, Hao Feng
Publikováno v:
Xenobiotica; the Fate of Foreign Compounds in Biological Systems
Apremilast is a novel, orally available small molecule that specifically inhibits PDE4 and thus modulates multiple pro- and anti-inflammatory mediators, and is currently under clinical development for the treatment of psoriasis and psoriatic arthriti
Autor:
Dorota Cedzik, Jörg H W Distler, Christian Beyer, Pawel Zerr, Simon Weingärtner, Alfiya Distler, Katrin Palumbo-Zerr, Peter H. Schafer, Clara Dees, Georg Schett, Sai L. Shankar, Oliver Distler, Michal Tomcik
Publikováno v:
Annals of the rheumatic diseases. 71(11)
ObjectivesTissue fibrosis is a major hallmark and a leading cause of death in systemic sclerosis (SSc). Here, we investigated the antifibrotic effects of pomalidomide, an analogue of thalidomide with potent immunomodulatory effects, in preclinical mo