Screening and characterisation of antimicrobial properties of semisynthetic betulin derivatives.

Autor: Shafiul Haque, Dorota A Nawrot, Sami Alakurtti, Leo Ghemtio, Jari Yli-Kauhaluoma, Päivi Tammela

Publikováno v: PLoS ONE, Vol 9, Iss 7, p e102696 (2014)

Betulin (lup-20(29)-ene-3β, 28-diol) is a naturally occurring triterpene, which is found in substantial amounts from the outer bark of birch trees. A library of 51 structurally diverse semisynthetic betulin derivatives was screened against five bact

Externí odkaz: https://doaj.org/article/fc5817bd3a1444539d9eefe420811408

Clinical validation of optimised RT-LAMP for the diagnosis of SARS-CoV-2 infection

Autor: Siqi Dai, Christos E. Zois, Sridhar R. Vasudevan, Harshmeena Sanghani, Susanne H. Hodgson, Zhanfeng Cui, Monique Andersson, Chia-Chen Hsu, Yejiong Yu, Jeremy Ratcliff, Simon Evans, Aikaterini Skeva, Hong Chang, Dorota A. Nawrot, Maria Adam, Wei E. Huang, Boon Leong Lim, Maria Panopoulou, Leon Peto, Katy Poncin, Shuai Ren, Peter Simmonds

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports

We have optimised a reverse transcription-loop-mediated isothermal amplification (RT-LAMP) assay for the detection of SARS-CoV-2 from extracted RNA for clinical application. We improved the stability and reliability of the RT-LAMP assay by the additi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75fdcb5a99cda3b21ac8d4a42221a12b
https://doaj.org/article/3a8b6fea2a544cd0a2eafc13f941fe38

A Novel High Content Angiogenesis Assay Reveals That Lacidipine, L-Type Calcium Channel Blocker, Induces In Vitro Vascular Lumen Expansion

Autor: Dorota A. Nawrot, Lutfiye Yildiz Ozer, Ayman Al Haj Zen

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 9; Pages: 4891

Angiogenesis is a critical cellular process toward establishing a functional circulatory system capable of delivering oxygen and nutrients to the tissue in demand. In vitro angiogenesis assays represent an important tool for elucidating the biology o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::672c537502dd60656000b214c75ded66
https://pubmed.ncbi.nlm.nih.gov/35563280

Bioactive Cembrane Derivatives from the Indian Ocean Soft Coral, Sinularia kavarattiensis

Autor: Lisette D'Souza, Harshada Adel, Katja-Emilia Lillsunde, Carmen Festa, Valter Lombardi, Dorota A. Nawrot, Päivi Tammela, Supriya Tilvi, Simona De Marino, Angela Zampella, Maria Valeria D'Auria

Publikováno v: Marine Drugs
Marine Drugs; Volume 12; Issue 7; Pages: 4045-4068
Marine Drugs, Vol 12, Iss 7, Pp 4045-4068 (2014)

Marine organisms and their metabolites represent a unique source of potential pharmaceutical substances. In this study, we examined marine-derived substances for their bioactive properties in a cell-based Chikungunya virus (CHIKV) replicon model and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df08707db49a374867c07cf3ec0ec6c5

The retinoid agonist tazarotene promotes angiogenesis and wound healing

Autor: Shoumo Bhattacharya, Daniel Ebner, Dorota A Nawrot, Andrea Caporali, Aude Vernet, Alison Howarth, Ayman Al Haj Zen, Jürgen E. Schneider

Publikováno v: Al Haj Zen, A, Nawrot, D, Howarth, A, Caporali, A, Ebner, D, Vernet, A, Schneider, J E & Bhattacharya, S 2016, ' The retinoid agonist Tazarotene promotes angiogenesis and wound healing ' . https://doi.org/10.1038/mt.2016.153

Therapeutic angiogenesis is a major goal ofregenerative medicine, but no clinically approved small molecule exists that enhancesnew blood vessel formation. Here we show, using a phenotype-driven high-content imaging screen of an annotated chemical li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a7fdf9d9bc90cbfa5c2f6f95844f1f7
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