Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Dorota, Stary"'
Autor:
Zofia Chrienova, David Rysanek, Patrik Oleksak, Dorota Stary, Marek Bajda, Milan Reinis, Romana Mikyskova, Ondrej Novotny, Rudolf Andrys, Adam Skarka, Pavla Vasicova, Josef Novak, Martin Valis, Kamil Kuca, Zdenek Hodny, Eugenie Nepovimova
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
To date, the most studied drug in anti-aging research is the mTOR inhibitor – rapamycin. Despite its almost perfect anti-aging profile, rapamycin exerts one significant limitation – inappropriate physicochemical properties. Therefore, we have dec
Externí odkaz:
https://doaj.org/article/2138141c119d4080852852773bb5684e
Autor:
Justyna Godyń, Paula Zaręba, Dorota Stary, Maria Kaleta, Kamil J. Kuder, Gniewomir Latacz, Szczepan Mogilski, David Reiner-Link, Annika Frank, Agata Doroz-Płonka, Agnieszka Olejarz-Maciej, Sylwia Sudoł-Tałaj, Tobias Nolte, Jadwiga Handzlik, Holger Stark, Anna Więckowska, Barbara Malawska, Katarzyna Kieć-Kononowicz, Dorota Łażewska, Marek Bajda
Publikováno v:
Molecules, Vol 28, Iss 1, p 238 (2022)
The multitarget-directed ligands demonstrating affinity to histamine H3 receptor and additional cholinesterase inhibitory potency represent a promising strategy for research into the effective treatment of Alzheimer’s disease. In this study, a nove
Externí odkaz:
https://doaj.org/article/2481fe283dea45f89bc7efb49683033f
Autor:
Dorota Łażewska, Paula Zaręba, Justyna Godyń, Agata Doroz-Płonka, Annika Frank, David Reiner-Link, Marek Bajda, Dorota Stary, Szczepan Mogilski, Agnieszka Olejarz-Maciej, Maria Kaleta, Holger Stark, Barbara Malawska, Katarzyna Kieć-Kononowicz
Publikováno v:
Molecules, Vol 26, Iss 12, p 3580 (2021)
Neurodegenerative diseases, e.g., Alzheimer’s disease (AD), are a key health problem in the aging population. The lack of effective therapy and diagnostics does not help to improve this situation. It is thought that ligands influencing multiple but
Externí odkaz:
https://doaj.org/article/d9e7c3fbce1d4dee984dbfe75cd18352
Autor:
Marek Bajda, Dorota Stary
Cancer cells are characterized by uncontrolled growth, proliferation, and impaired apoptosis. Tumour progression could be related to poor prognosis and due to this fact, researchers have been working on novel therapeutic strategies and antineoplastic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44f7d3ad82e4e027141a02b7988eb7e7
https://ruj.uj.edu.pl/xmlui/handle/item/308645
https://ruj.uj.edu.pl/xmlui/handle/item/308645
Publikováno v:
Chemical biologydrug designREFERENCES.
The mammalian target of rapamycin (mTOR) is an important biological target for development of novel anticancer drugs and potential antiageing agents. Therefore, many scientific groups search for mTOR kinase inhibitors. Herein, we present structure-ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19f62a0f133fae03b99de5709940480a
https://pubmed.ncbi.nlm.nih.gov/35945665
https://pubmed.ncbi.nlm.nih.gov/35945665
Autor:
Agnieszka Zagórska, Marek Bajda, Marta Struga, Dorota Stary, Magdalena Mielczarek-Puta, Anna Czopek, Anna Jaromin
Publikováno v:
Materials
Volume 14
Issue 15
Materials, Vol 14, Iss 4156, p 4156 (2021)
Volume 14
Issue 15
Materials, Vol 14, Iss 4156, p 4156 (2021)
Cancer represents one of the most serious health problems and the second leading cause of death around the world. Heterocycles, due to their prevalence in nature as well as their structural and chemical diversity, play an immensely important role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::795ffba13ff17bf5bdca319e817f953c
http://europepmc.org/articles/PMC8347464
http://europepmc.org/articles/PMC8347464
Autor:
Justyna, Godyń, Paula, Zaręba, Dorota, Łażewska, Dorota, Stary, David, Reiner-Link, Annika, Frank, Gniewomir, Latacz, Szczepan, Mogilski, Maria, Kaleta, Agata, Doroz-Płonka, Annamaria, Lubelska, Ewelina, Honkisz-Orzechowska, Agnieszka, Olejarz-Maciej, Jadwiga, Handzlik, Holger, Stark, Katarzyna, Kieć-Kononowicz, Barbara, Malawska, Marek, Bajda
Publikováno v:
Bioorganic chemistry. 114
Alzheimer's disease (AD) is a complex and incurable illness that requires the urgent approval of new effective drugs. However, since 2003, no new molecules have shown successful results in clinical trials, thereby making the common "one compound - on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e68e231b6213058a056bf9df683473f3
https://pubmed.ncbi.nlm.nih.gov/34217977
https://pubmed.ncbi.nlm.nih.gov/34217977
Autor:
Dorota Stary, Marharyta Barbasevich, Jędrzej Kukułowicz, Izabella Góral, Marek Bajda, Hanna Baltrukevich, Justyna Godyń
Thymidine phosphorylase (TP) is an enzyme which catalyses the conversion of thymidine to thymine and 2-deoxy-α- d -ribose-1-phosphate. The 2-deoxy-α- d -ribose-1-phosphate is then dephosphorylated to the 2-deoxy-α- d -ribose, which can promote ang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd4540dc682851481ed93e8dee3b5c2
https://ruj.uj.edu.pl/xmlui/handle/item/283281
https://ruj.uj.edu.pl/xmlui/handle/item/283281
Autor:
Marek Bajda, Paweł Kręcisz, Monika Karpińska, Beata Paw, Paweł Szymański, Joanna Matysiak, Kamila Czarnecka, Alicja Skrzypek, Dorota Stary, Andrzej Niewiadomy, Jędrzej Kukułowicz
Publikováno v:
Bioorganic chemistry. 107
Two series of novel 1,3,4-thiadiazole-resorcinol conjugates were efficiently synthesized and evaluated as cholinesterases inhibitors. N-Butyl- and N-chlorophenyl-5-amino-1,3,4-thiadiazol-2-yl)benzene-1,3-diols were identified as the most promising co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa2fbb039afd10ad812d5bdd7f8300d9
https://pubmed.ncbi.nlm.nih.gov/33444983
https://pubmed.ncbi.nlm.nih.gov/33444983
Autor:
Dorota, Łażewska, Marek, Bajda, Maria, Kaleta, Paula, Zaręba, Agata, Doroz-Płonka, Agata, Siwek, Alaa, Alachkar, Szczepan, Mogilski, Ali, Saad, Kamil, Kuder, Agnieszka, Olejarz-Maciej, Justyna, Godyń, Dorota, Stary, Sylwia, Sudoł, Małgorzata, Więcek, Gniewomir, Latacz, Maria, Walczak, Jadwiga, Handzlik, Bassem, Sadek, Barbara, Malawska, Katarzyna, Kieć-Kononowicz
Publikováno v:
European journal of medicinal chemistry. 207
Design and development of multitarget-directed ligands (MTDLs) has become a very important approach in the search of new therapies for Alzheimer's disease (AD). In our present research, a number of xanthone derivatives were first designed using a pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::19b9ce0cd6668a224d31e97fea8dca07
https://pubmed.ncbi.nlm.nih.gov/32882609
https://pubmed.ncbi.nlm.nih.gov/32882609