Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Dorota, Dworakowska"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 900 (2024)
Primary aldosteronism (PA), a significant and curable cause of secondary hypertension, is seen in 5–10% of hypertensive patients, with its prevalence contingent upon the severity of the hypertension. The principal aetiologies of PA include bilatera
Externí odkaz:
https://doaj.org/article/dd9c0c7ff2c64c6f86db19a286c8560c
Autor:
Dorota Dworakowska, Ashley B. Grossman
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Acromegaly results in a significantly increased morbidity and mortality due to cardiovascular and respiratory complications, as well as malignancies arising mainly from the colon. Furthermore, an increased lifetime risk of malignant transformation of
Externí odkaz:
https://doaj.org/article/b4982e2ceba64922a3cf274b8fedcc04
Publikováno v:
Clinical Endocrinology
Autor:
Dorota Dworakowska, Ashley B. Grossman
Publikováno v:
Endocrine-related cancer. 25(11)
Pituitary adenomas are unique in multiple ways. They are rarely malignant in terms of metastases; yet, they may be aggressive. Their cancerous potential is defined in a classic oncological way by the ability to metastasise, and therefore, it has been
Autor:
Dorota Dworakowska, Agata Drabarek, Anna Babińska, Ingrid Wenzel, Renata Świątkowska-Stodulska, Krzysztof Sworczak
Publikováno v:
Endokrynologia Polska. 65:492-512
Adrenocortical carcinoma (ACC) is a malignant endocrine tumour. The rarity of the disease has stymied therapeutic development. Age distribution shows two peaks: the first and fifth decades of life, with children and women more frequently affected. Al
Autor:
Ashley B. Grossman, Stefan R. Bornstein, Paulina Szyszka, Gregory Weitsman, Salvador J. Diaz-Cano, Tony Ng, Márta Korbonits, Dorota Dworakowska
Publikováno v:
Endocrine Abstracts.
Publikováno v:
Scopus-Elsevier
Pituitary adenomas present with a variety of clinical endocrine manifestations and arise in a sporadic setting or rarely as part of hereditary genetic syndromes. Molecular analysis of familial pituitary adenomas has provided significant insight into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b549b0b7173d9e16550a71b633576b7
https://ora.ox.ac.uk/objects/uuid:a5891c4a-73a8-4535-8f6c-051df696ed41
https://ora.ox.ac.uk/objects/uuid:a5891c4a-73a8-4535-8f6c-051df696ed41
Autor:
Ashley B. Grossman, Mehtap Cakir, Miklós Góth, Susana Igreja, Maria Gueorguiev, Elizabeth Wlodek, Chrysanthia A. Leontiou, Blerina Kola, Dorota Dworakowska, Simona Grozinsky-Glasberg, Márta Korbonits, Natalia V. Prodromou, Mable Teng
WOS: 000272670500022
PubMed: 19620247
Raf/MEK/ERK and phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) cascades are key signalling pathways interacting with each other to regulate cell growth and tumourigenesis.
PubMed: 19620247
Raf/MEK/ERK and phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) cascades are key signalling pathways interacting with each other to regulate cell growth and tumourigenesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d5f4d8bc1d0dd939ae3ac5ba4e6b91
https://doi.org/10.1677/erc-09-0101
https://doi.org/10.1677/erc-09-0101
Autor:
Paulina, Szyszka, Ashley B, Grossman, Salvador, Diaz-Cano, Krzysztof, Sworczak, Dorota, Dworakowska
Publikováno v:
Endokrynologia Polska. 67(4)
Adrenocortical carcinoma is associated with a low cure rate and a high recurrence rate. The prognosis is poor, and at diagnosis 30-40% of cases are already metastatic. The current therapeutic options (surgical resection, followed by adjuvant mitotane
Introduction:Adrenocortical carcinoma (ACC) is a rare disease with a poor prognosis and limited therapeutic options.Aim:The objective of this study was to assess the anti-proliferative effect of combinatorial targeting of the PI3K/Akt/mTOR pathway wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb3c2593bccbd077ef24f9e36d049c2