VEGFA Status as a Predictive Marker of Therapy Outcome in Metastatic Gastric Cancer Patients Following Ramucirumab-Based Treatment

Autor: Annalisa Schirizzi, Aram Arshadi, Doron Tolomeo, Laura Schirosi, Anna Maria Valentini, Giampiero De Leonardis, Maria Grazia Refolo, Rossella Donghia, Clelia Tiziana Storlazzi, Alfredo Zito, Angela Dalia Ricci, Simona Vallarelli, Carmela Ostuni, Maria Bencivenga, Giovanni De Manzoni, Caterina Messa, Raffaele Armentano, Gianluigi Giannelli, Claudio Lotesoriere, Rosalba D’Alessandro

Publikováno v: Biomedicines, Vol 11, Iss 10, p 2721 (2023)

Metastatic gastric cancer (mGC) often has a poor prognosis and may benefit from a few targeted therapies. Ramucirumab-based anti-angiogenic therapy targeting the VEGFR2 represents a milestone in the second-line treatment of mGC. Several studies on di

Externí odkaz: https://doaj.org/article/4e8a709cb37c4383a6a564c6da1935bb

IGFBP-6 Network in Chronic Inflammatory Airway Diseases and Lung Tumor Progression

Autor: Santina Venuto, Anna Rita Daniela Coda, Ruperto González-Pérez, Onofrio Laselva, Doron Tolomeo, Clelia Tiziana Storlazzi, Arcangelo Liso, Massimo Conese

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 5, p 4804 (2023)

The lung is an accomplished organ for gas exchanges and directly faces the external environment, consequently exposing its large epithelial surface. It is also the putative determinant organ for inducing potent immune responses, holding both innate a

Externí odkaz: https://doaj.org/article/dcffca0ec8bf450998939187bae4d56e

circPVT1 and PVT1/AKT3 show a role in cell proliferation, apoptosis, and tumor subtype-definition in small cell lung cancer

Autor: Doron Tolomeo, Debora Traversa, Santina Venuto, Karoline K. Ebbesen, Juan L. García Rodríguez, Grazia Tamma, Marianna Ranieri, Giorgia Simonetti, Martina Ghetti, Matteo Paganelli, Grazia Visci, Arcangelo Liso, Klaas Kok, Lucia Anna Muscarella, Federico Pio Fabrizio, Maria Antonia Frassanito, Aurelia Lamanuzzi, Ilaria Saltarella, Antonio Giovanni Solimando, Alessandro Fatica, Zaira Ianniello, René Massimiliano Marsano, Antonio Palazzo, Amalia Azzariti, Vito Longo, Stefania Tommasi, Domenico Galetta, Annamaria Catino, Alfredo Zito, Tommaso Mazza, Alessandro Napoli, Giovanni Martinelli, Jørgen Kjems, Lasse Sommer Kristensen, Angelo Vacca, Clelia Tiziana Storlazzi

Publikováno v: Genes Chromosomes and Cancer. Wiley
Tolomeo, D, Traversa, D, Venuto, S, Ebbesen, K, Garcia Rodriguez, J L, Tamma, G, Ranieri, M, Simonetti, G, Ghetti, M, Paganelli, M, Visci, G, Liso, A, Kok, K, Muscarella, L A, Fabrizio, F P, Frassanito, M A, Lamanuzzi, A, Saltarella, I, Solimando, A G, Fatica, A, Ianiello, Z, Marsano, R M, Palazzo, A, Azzariti, A, Longo, V, Tommasi, S, Galetta, D, Catino, A, ZIto, A, Mazza, T, Napoli, A, Martinelli, G, Kjems, J, Kristensen, L S, Vacca, A & Storlazzi, C T 2023, ' circPVT1 and PVT1/AKT3 show a role in cell proliferation, apoptosis, and tumor subtype-definition in Small Cell Lung Cancer ', Genes, Chromosomes & Cancer, vol. 62, no. 7, pp. 377-391 . https://doi.org/10.1002/gcc.23121

Small Cell Lung Cancer (SCLC) is treated as a homogeneous disease, although the expression of NEUROD1, ASCL1, POU2F3, and YAP1 identifies distinct molecular subtypes. The MYC oncogene, amplified in SCLC, was recently shown to act as a lineage-specifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40db04445498364c91794a11b046764c
https://research.rug.nl/en/publications/fb27f467-19bc-432d-aa78-95dc980623af

BL1391: an established cell line from a human malignant peripheral nerve sheath tumor with unique genomic features

Autor: Doron Tolomeo, Gemma Macchia, Vito Racanelli, Clelia Tiziana Storlazzi, Ingrid Cifola, Fredrik Mertens, Maria Antonia Frassanito, Alberto L'Abbate, Marco Severgnini, Felix Haglund, Antonio Agostini, Antonio Giovanni Solimando

Publikováno v: Human cell 34 (2021): 238–245. doi:10.1007/s13577-020-00418-7
info:cnr-pdr/source/autori:Tolomeo, Doron; Agostini, Antonio; Macchia, Gemma; L'Abbate, Alberto; Severgnini, Marco; Cifola, Ingrid; Frassanito, Maria Antonia; Racanelli, Vito; Solimando, Antonio Giovanni; Haglund, Felix; Mertens, Fredrik; Storlazzi, Clelia Tiziana/titolo:BL1391: an established cell line from a human malignant peripheral nerve sheath tumor with unique genomic features/doi:10.1007%2Fs13577-020-00418-7/rivista:Human cell/anno:2021/pagina_da:238/pagina_a:245/intervallo_pagine:238–245/volume:34

Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive tumors, accounting for around 5% of all soft tissue sarcomas. A better understanding of the pathogenesis of these tumors and the development of effective treatments are needed. In this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5580c48154aafdf0c760247205bb1cc
https://doi.org/10.1007/s13577-020-00418-7

Abstract 1555: circPVT1 and linear PVT1 isoforms regulate cell growth, metabolic and DNA damage response related gene signatures in acute myeloid leukemia

Autor: Martina Ghetti, Antonella Padella, Eugenio Fonzi, Lorenzo Ledda, Andrea Ghelli Lusernadi Rorà, Matteo Paganelli, Doron Tolomeo, Clelia Tiziana Storlazzi, Giovanni Martinelli, Giorgia Simonetti

Publikováno v: Cancer Research. 82:1555-1555

Non-coding (nc)RNAs, including circular (circ)RNAs, contribute to tumor development and progression. Several ncRNAs were shown to affect the onset, prognosis, and treatment of acute myeloid leukemia (AML) in the past years. The human Plasmacytoma Var

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88f7b25e0363c90bb93d02f216f8adb2
https://doi.org/10.1158/1538-7445.am2022-1555