Zobrazeno 1 - 10
of 204
pro vyhledávání: '"Doron Merkler"'
Antigen recognition detains CD8+ T cells at the blood-brain barrier and contributes to its breakdown
Autor:
Sidar Aydin, Javier Pareja, Vivianne M. Schallenberg, Armelle Klopstein, Thomas Gruber, Nicolas Page, Elisa Bouillet, Nicolas Blanchard, Roland Liblau, Jakob Körbelin, Markus Schwaninger, Aaron J. Johnson, Mirjam Schenk, Urban Deutsch, Doron Merkler, Britta Engelhardt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Blood-brain barrier (BBB) breakdown and immune cell infiltration into the central nervous system (CNS) are early hallmarks of multiple sclerosis (MS). High numbers of CD8+ T cells are found in MS lesions, and antigen (Ag) presentation at the
Externí odkaz:
https://doaj.org/article/5dc449b410d94851b2e874ed632dc890
Autor:
Laura Empl, Alexandra Chovsepian, Maryam Chahin, Wing Yin Vanessa Kan, Julie Fourneau, Valérie Van Steenbergen, Sanofer Weidinger, Maite Marcantoni, Alexander Ghanem, Peter Bradley, Karl Klaus Conzelmann, Ruiyao Cai, Alireza Ghasemigharagoz, Ali Ertürk, Ingrid Wagner, Mario Kreutzfeldt, Doron Merkler, Sabine Liebscher, Florence M. Bareyre
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Which contralesional circuits adapt after traumatic brain injury (TBI) is unclear. Here the authors used in vivo imaging, retrograde labeling, rabies tracing, clearing and functional imaging to demonstrate that callosal neurons selectively adapt afte
Externí odkaz:
https://doaj.org/article/1ae8af63caf147c5851d208a6526975f
Autor:
Diego von Werdt, Bilgi Gungor, Juliana Barreto de Albuquerque, Thomas Gruber, Daniel Zysset, Cheong K. C. Kwong Chung, Antonia Corrêa-Ferreira, Regina Berchtold, Nicolas Page, Mirjam Schenk, John H. Kehrl, Doron Merkler, Beat A. Imhof, Jens V. Stein, Jun Abe, Gleb Turchinovich, Daniela Finke, Adrian C. Hayday, Nadia Corazza, Christoph Mueller
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Members of the Regulator of G-protein signaling (Rgs) family regulate the extent and timing of G protein signaling by increasing the GTPase activity of Gα protein subunits. The Rgs family member Rgs1 is one of the most up-regulated genes in tissue-r
Externí odkaz:
https://doaj.org/article/6d79eafde35e4c45ade9ec45a1191aae
Autor:
Mahdia Benkhoucha, Ngoc Lan Tran, Gautier Breville, Isis Senoner, Paul F. Bradfield, Thalia Papayannopoulou, Doron Merkler, Thomas Korn, Patrice H. Lalive
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-19 (2022)
Abstract Objective c-Met, a tyrosine kinase receptor, is the unique receptor for hepatocyte growth factor (HGF). The HGF/c-Met axis is reported to modulate cell migration, maturation, cytokine production, and antigen presentation. Here, we report tha
Externí odkaz:
https://doaj.org/article/a6b2cea755e146b8bff23ade4c459ccc
Autor:
Giuseppe Ercolano, Alejandra Gomez-Cadena, Nina Dumauthioz, Giulia Vanoni, Mario Kreutzfeldt, Tania Wyss, Liliane Michalik, Romain Loyon, Angela Ianaro, Ping-Chih Ho, Christophe Borg, Manfred Kopf, Doron Merkler, Philippe Krebs, Pedro Romero, Sara Trabanelli, Camilla Jandus
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Group 2 innate lymphoid cells (ILC2s) are a component of type 2 immune response recently described to be involved in the regulation of anti-tumor immune responses. Here, the authors show that the expression of the peroxisome proliferator-activated re
Externí odkaz:
https://doaj.org/article/b884462c3efa444ba2a11976dff87142
Autor:
Noushin Hadadi, Martina Spiljar, Karin Steinbach, Melis Çolakoğlu, Claire Chevalier, Gabriela Salinas, Doron Merkler, Mirko Trajkovski
Publikováno v:
eLife, Vol 11 (2022)
Thermal adaptation is an extensively used intervention for enhancing or suppressing thermogenic and mitochondrial activity in adipose tissues. As such, it has been suggested as a potential lifestyle intervention for body weight maintenance. While the
Externí odkaz:
https://doaj.org/article/e67b272d9abb40259c0cbfce2f70aaf0
Autor:
Nicolas Page, Sylvain Lemeille, Ilena Vincenti, Bogna Klimek, Alexandre Mariotte, Ingrid Wagner, Giovanni Di Liberto, Jonathan Kaye, Doron Merkler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The transcriptional adaptation processes of harmful self-reactive CD8+ T cells in the central nervous system are not well understood. Here the authors use a system in which self-reactive and virally generated CD8+ T cells are directly compared in viv
Externí odkaz:
https://doaj.org/article/0a1022f34c2d437e8a387d622d23d03f
Autor:
Raphael Kuhn, Ioana Sandu, Andreas Agrafiotis, Kai-Lin Hong, Danielle Shlesinger, Daniel Neimeier, Doron Merkler, Annette Oxenius, Sai T. Reddy, Alexander Yermanos
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
CD8+ T cells play a crucial role in the control and resolution of viral infections and can adopt a wide range of phenotypes and effector functions depending on the inflammatory context and the duration and extent of antigen exposure. Similarly, viral
Externí odkaz:
https://doaj.org/article/3fe6fda7adbd4b97a8c9ea15e226f3d6
Autor:
Elodie Belnoue, Alexis Vogelzang, Natalie E. Nieuwenhuizen, Magdalena A. Krzyzaniak, Stephanie Darbre, Mario Kreutzfeldt, Ingrid Wagner, Doron Merkler, Paul-Henri Lambert, Stefan H. E. Kaufmann, Claire-Anne Siegrist, Daniel D. Pinschewer
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 5, p 2700 (2022)
Mycobacterium tuberculosis (Mtb) represents a major burden to global health, and refined vaccines are needed. Replication-deficient lymphocytic choriomeningitis virus (rLCMV)-based vaccine vectors against cytomegalovirus have proven safe for human us
Externí odkaz:
https://doaj.org/article/b421034da74d414f9cc6b9ed8a6f863c
Autor:
Nina Steinemann, Jens Kuhle, Pasquale Calabrese, Jürg Kesselring, Giulio Disanto, Doron Merkler, Caroline Pot, Vladeta Ajdacic-Gross, Stephanie Rodgers, Milo Alan Puhan, Viktor von Wyl, the Swiss Multiple Sclerosis Registry
Publikováno v:
BMC Neurology, Vol 18, Iss 1, Pp 1-10 (2018)
Abstract Background Multiple sclerosis (MS) is one of the most frequently observed neurological conditions in Switzerland, but data sources for country-wide epidemiological trend monitoring are lacking. Moreover, while clinical and laboratory MS rese
Externí odkaz:
https://doaj.org/article/422f0e34039d4c4e956bdfbb95f705e0