Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy.

Autor: Drake JC; Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908; zy3m@virginia.edu joshuacd@vt.edu.; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061., Wilson RJ; Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908.; Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908., Laker RC; Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908., Guan Y; Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908.; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908., Spaulding HR; Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908., Nichenko AS; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061., Shen W; Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908., Shang H; Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908., Dorn MV; Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908., Huang K; Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908., Zhang M; Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908.; Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908., Bandara AB; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061., Brisendine MH; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061., Kashatus JA; Department of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA 22908., Sharma PR; Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville, VA 22908., Young A; Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908., Gautam J; Department of Nephrology, University of Virginia School of Medicine, Charlottesville, VA 22908., Cao R; W. M. Keck Center for Cellular Imaging, University of Virginia, Charlottesville, VA 22904., Wallrabe H; W. M. Keck Center for Cellular Imaging, University of Virginia, Charlottesville, VA 22904.; Department of Biology, University of Virginia, Charlottesville, VA 22904., Chang PA; Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305., Wong M; Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305., Desjardins EM; Centre for Metabolism, Obesity and Diabetes Research, Department of Medicine, McMaster University, Hamilton ON L8N 3Z5, Canada.; Department of Medicine, McMaster University, Hamilton ON L8N 3Z5, Canada., Hawley SA; Division of Cell Signaling and Immunology, School of Life Sciences, University of Dundee, DD1 5EH Scotland, United Kingdom., Christ GJ; Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville, VA 22908.; Department of Orthopaedic Surgery, University of Virginia School of Medicine, Charlottesville, VA 22908., Kashatus DF; Department of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA 22908., Miller CL; Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908.; Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville, VA 22908.; Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA 22908.; Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA 22908., Wolf MJ; Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908.; Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908., Periasamy A; W. M. Keck Center for Cellular Imaging, University of Virginia, Charlottesville, VA 22904.; Department of Biology, University of Virginia, Charlottesville, VA 22904., Steinberg GR; Centre for Metabolism, Obesity and Diabetes Research, Department of Medicine, McMaster University, Hamilton ON L8N 3Z5, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton ON L8N 3Z5, Canada., Hardie DG; Division of Cell Signaling and Immunology, School of Life Sciences, University of Dundee, DD1 5EH Scotland, United Kingdom., Yan Z; Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908; zy3m@virginia.edu joshuacd@vt.edu.; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908.; Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908.; Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22908.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Sep 14; Vol. 118 (37).