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pro vyhledávání: '"Dormarie Rivera-Rodriguez"'
Autor:
Joan D. Beckman, Fuad Abdullah, Chunsheng Chen, Rachel Kirchner, Dormarie Rivera-Rodriguez, Zachary M. Kiser, Aithanh Nguyen, Ping Zhang, Julia Nguyen, Robert P. Hebbel, John D. Belcher, Gregory M. Vercellotti
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Heme, released from red blood cells in sickle cell disease (SCD), interacts with toll-like receptor 4 (TLR4) to activate NF-κB leading to the production of cytokines and adhesion molecules which promote inflammation, pain, and vaso-occlusion. In SCD
Externí odkaz:
https://doaj.org/article/8b85be8fe59f4192a1fe566fbb2c75ec
Autor:
Rachel Kirchner, Gregory M. Vercellotti, Zachary Monroe Kiser, Joan D. Beckman, Robert P. Hebbel, Julia Nguyen, Dormarie Rivera-Rodriguez, John D. Belcher, Aithanh Nguyen, Fuad Abdullah, Chunsheng Chen, Ping Zhang
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Frontiers in Immunology
Frontiers in Immunology
Heme, released from red blood cells in sickle cell disease (SCD), interacts with toll-like receptor 4 (TLR4) to activate NF-κB leading to the production of cytokines and adhesion molecules which promote inflammation, pain, and vaso-occlusion. In SCD
Autor:
John D. Belcher, Julia Nguyen, Kristine Nachbor, Zachary Monroe Kiser, Dormarie Rivera-Rodriguez, Jacob Lloyd, Chunsheng Chen, Fuad Abdulla, Rachel Kirchner, Gregory M. Vercellotti, Ping Zhang
Publikováno v:
Blood. 134:3555-3555
We have previously shown that heme, a damage-associated molecular pattern (DAMP), released from sickle RBCs interacts with the innate immune toll-like receptor 4 (TLR4) on endothelium and blood cells to activate cell signaling. This activates the pro